Abstract
1. 1. This study examines the efficacy of infused sodium chenodeoxycholate to prevent cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet. 2. 2. Three experimental groups were designed to examine this. The first group (N = 5) was fed a normal rat chow diet, the second group (N = 5) was fed a high cholesterol diet (0.4% cholesterol by weight), and the third group (N = 5) was fed a high cholesterol diet plus given a daily injection of intravenous sodium chenodeoxycholate (15 mg/kg). 3. 3. All of the animals in the second group had cholesterol crystals and cholesterol gallstones. In the third group, none of the animals had gallstones, and all but one lacked cholesterol crystals. 4. 4. Statistical analysis showed that the first and third groups were statistically identical in their lithogenic indices and biliary lipid composition. 5. 5. We concluded that infused sodium chenodeoxyeholate is effective in preventing cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet.
| Original language | English |
|---|---|
| Pages (from-to) | 609-613 |
| Number of pages | 5 |
| Journal | Comparative Biochemistry and Physiology -- Part A: Physiology |
| Volume | 99 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1991 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Physiology
- Molecular Biology
- Biochemistry
Cite this
The prevention of cholelithiasis with infused sodium chenodeoxycholate in the prairie dog (Cynomys ludovicianus). / Broughton, George; Tseng, Anthony; Fitzgibbons, Robert Joseph; Tyndall, Steven; Stanislav, Gregory; Rongone, Edward L.
In: Comparative Biochemistry and Physiology -- Part A: Physiology, Vol. 99, No. 4, 1991, p. 609-613.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The prevention of cholelithiasis with infused sodium chenodeoxycholate in the prairie dog (Cynomys ludovicianus)
AU - Broughton, George
AU - Tseng, Anthony
AU - Fitzgibbons, Robert Joseph
AU - Tyndall, Steven
AU - Stanislav, Gregory
AU - Rongone, Edward L.
PY - 1991
Y1 - 1991
N2 - 1. 1. This study examines the efficacy of infused sodium chenodeoxycholate to prevent cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet. 2. 2. Three experimental groups were designed to examine this. The first group (N = 5) was fed a normal rat chow diet, the second group (N = 5) was fed a high cholesterol diet (0.4% cholesterol by weight), and the third group (N = 5) was fed a high cholesterol diet plus given a daily injection of intravenous sodium chenodeoxycholate (15 mg/kg). 3. 3. All of the animals in the second group had cholesterol crystals and cholesterol gallstones. In the third group, none of the animals had gallstones, and all but one lacked cholesterol crystals. 4. 4. Statistical analysis showed that the first and third groups were statistically identical in their lithogenic indices and biliary lipid composition. 5. 5. We concluded that infused sodium chenodeoxyeholate is effective in preventing cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet.
AB - 1. 1. This study examines the efficacy of infused sodium chenodeoxycholate to prevent cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet. 2. 2. Three experimental groups were designed to examine this. The first group (N = 5) was fed a normal rat chow diet, the second group (N = 5) was fed a high cholesterol diet (0.4% cholesterol by weight), and the third group (N = 5) was fed a high cholesterol diet plus given a daily injection of intravenous sodium chenodeoxycholate (15 mg/kg). 3. 3. All of the animals in the second group had cholesterol crystals and cholesterol gallstones. In the third group, none of the animals had gallstones, and all but one lacked cholesterol crystals. 4. 4. Statistical analysis showed that the first and third groups were statistically identical in their lithogenic indices and biliary lipid composition. 5. 5. We concluded that infused sodium chenodeoxyeholate is effective in preventing cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet.
UR - http://www.scopus.com/inward/record.url?scp=0025849039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025849039&partnerID=8YFLogxK
U2 - 10.1016/0300-9629(91)90138-3
DO - 10.1016/0300-9629(91)90138-3
M3 - Article
VL - 99
SP - 609
EP - 613
JO - Comparative Biochemistry and Physiology - A Physiology
JF - Comparative Biochemistry and Physiology - A Physiology
SN - 1095-6433
IS - 4
ER -