The prevention of cholelithiasis with infused sodium chenodeoxycholate in the prairie dog (Cynomys ludovicianus)

George Broughton, Anthony Tseng, Robert Fitzgibbons, Steven Tyndall, Gregory Stanislav, Edward L. Rongone

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

1. 1. This study examines the efficacy of infused sodium chenodeoxycholate to prevent cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet. 2. 2. Three experimental groups were designed to examine this. The first group (N = 5) was fed a normal rat chow diet, the second group (N = 5) was fed a high cholesterol diet (0.4% cholesterol by weight), and the third group (N = 5) was fed a high cholesterol diet plus given a daily injection of intravenous sodium chenodeoxycholate (15 mg/kg). 3. 3. All of the animals in the second group had cholesterol crystals and cholesterol gallstones. In the third group, none of the animals had gallstones, and all but one lacked cholesterol crystals. 4. 4. Statistical analysis showed that the first and third groups were statistically identical in their lithogenic indices and biliary lipid composition. 5. 5. We concluded that infused sodium chenodeoxyeholate is effective in preventing cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume99
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology

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