The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects

I. Caroline Crocker, Kirtibala Gupta, Robert G. Townley, Manzoor M. Khan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study investigated cytokine release by T-cell lines from atopic and nonatopic individuals in the presence of specific aeroallergen. Cell lines from atopic and nonatopic individuals secreted IL-2 for less than 14 and more than 21 days, respectively. All of the atopic, but not the nonatopic, cell lines exhibited a biphasic peak in IL-4 and IL-5 secretion. Flow cytometry revealed that, after 35 days, 89.3% of the atopic cells were T helpers and 73.2% were activated. Only 7.4% of the nonatopic cells displayed activation markers. In conclusion, T-cell differentiation may be controlled by other factors in addition to stimulation by aeroallergens.

Original languageEnglish
Pages (from-to)187-201
Number of pages15
JournalJournal of Asthma
Volume35
Issue number2
StatePublished - 1998

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Helper-Inducer T-Lymphocytes
Cytokines
Cell Line
T-Lymphocytes
Interleukin-5
Interleukin-4
Interleukin-2
Cell Differentiation
Flow Cytometry

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Crocker, I. C., Gupta, K., Townley, R. G., & Khan, M. M. (1998). The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects. Journal of Asthma, 35(2), 187-201.

The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects. / Crocker, I. Caroline; Gupta, Kirtibala; Townley, Robert G.; Khan, Manzoor M.

In: Journal of Asthma, Vol. 35, No. 2, 1998, p. 187-201.

Research output: Contribution to journalArticle

Crocker, IC, Gupta, K, Townley, RG & Khan, MM 1998, 'The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects', Journal of Asthma, vol. 35, no. 2, pp. 187-201.
Crocker, I. Caroline ; Gupta, Kirtibala ; Townley, Robert G. ; Khan, Manzoor M. / The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects. In: Journal of Asthma. 1998 ; Vol. 35, No. 2. pp. 187-201.
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