The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects

I. Caroline Crocker, Kirtibala Gupta, Robert G. Townley, Manzoor M. Khan

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This study investigated cytokine release by T-cell lines from atopic and nonatopic individuals in the presence of specific aeroallergen. Cell lines from atopic and nonatopic individuals secreted IL-2 for less than 14 and more than 21 days, respectively. All of the atopic, but not the nonatopic, cell lines exhibited a biphasic peak in IL-4 and IL-5 secretion. Flow cytometry revealed that, after 35 days, 89.3% of the atopic cells were T helpers and 73.2% were activated. Only 7.4% of the nonatopic cells displayed activation markers. In conclusion, T-cell differentiation may be controlled by other factors in addition to stimulation by aeroallergens.

Original languageEnglish (US)
Pages (from-to)187-201
Number of pages15
JournalJournal of Asthma
Volume35
Issue number2
DOIs
StatePublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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