The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects

I. Caroline Crocker, Kirtibala Gupta, Robert G. Townley, Manzoor M. Khan

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Abstract

This study investigated cytokine release by T-cell lines from atopic and nonatopic individuals in the presence of specific aeroallergen. Cell lines from atopic and nonatopic individuals secreted IL-2 for less than 14 and more than 21 days, respectively. All of the atopic, but not the nonatopic, cell lines exhibited a biphasic peak in IL-4 and IL-5 secretion. Flow cytometry revealed that, after 35 days, 89.3% of the atopic cells were T helpers and 73.2% were activated. Only 7.4% of the nonatopic cells displayed activation markers. In conclusion, T-cell differentiation may be controlled by other factors in addition to stimulation by aeroallergens.

Original languageEnglish
Pages (from-to)187-201
Number of pages15
JournalJournal of Asthma
Volume35
Issue number2
Publication statusPublished - 1998

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All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Crocker, I. C., Gupta, K., Townley, R. G., & Khan, M. M. (1998). The profile of the cytokines secreted during the generation of T-helper cells from atopic asthmatic subjects. Journal of Asthma, 35(2), 187-201.