The progression of Alzheimer's disease from limbic regions to the neocortex

Clinical, radiological and pathological relationships

Zsuzsanna Nagy, N. J. Hindley, H. Braak, E. Braak, D. M. Yilmazer-Hanke, C. Schultz, L. Barnetson, E. M F King, K. A. Jobst, A. D. Smith

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is characterised by the gradual accumulation of neurofibrillary pathology in selected regions of the brain. Earlier studies indicate that the accumulation of neurofibrillary tangles is associated both with decline in patient's cognitive performance as well as with medial temporal lobe atrophy on CT scans. There are also indications that progression through the pathological stages of AD is associated with decline in cognitive functions. The results of this study indicate that progression of disease, especially beyond the boundaries of the limbic regions, is associated with marked decline in the cognitive performance of patients suffering from AD. However the clinical manifestations of early pathological stages are not so well defined. We also found that the atrophy of the medial temporal lobe on CT scans is related to the progression of pathology. Atrophy is most apparent when the disease reaches its isocortical stages and is not marked in the limbic stages of the disease. The additive effect of pathologies co-existing with AD is apparent in reduced cognitive scores, while the atrophy of limbic structures, as measured on CT scans, seems to be mainly attributable to AD-related pathology.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume10
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

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Neocortex
Alzheimer Disease
Atrophy
Pathology
Temporal Lobe
Neurofibrillary Tangles
Cognition
Disease Progression
Brain

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

The progression of Alzheimer's disease from limbic regions to the neocortex : Clinical, radiological and pathological relationships. / Nagy, Zsuzsanna; Hindley, N. J.; Braak, H.; Braak, E.; Yilmazer-Hanke, D. M.; Schultz, C.; Barnetson, L.; King, E. M F; Jobst, K. A.; Smith, A. D.

In: Dementia and Geriatric Cognitive Disorders, Vol. 10, No. 2, 1999, p. 115-120.

Research output: Contribution to journalArticle

Nagy, Z, Hindley, NJ, Braak, H, Braak, E, Yilmazer-Hanke, DM, Schultz, C, Barnetson, L, King, EMF, Jobst, KA & Smith, AD 1999, 'The progression of Alzheimer's disease from limbic regions to the neocortex: Clinical, radiological and pathological relationships', Dementia and Geriatric Cognitive Disorders, vol. 10, no. 2, pp. 115-120. https://doi.org/10.1159/000017111
Nagy, Zsuzsanna ; Hindley, N. J. ; Braak, H. ; Braak, E. ; Yilmazer-Hanke, D. M. ; Schultz, C. ; Barnetson, L. ; King, E. M F ; Jobst, K. A. ; Smith, A. D. / The progression of Alzheimer's disease from limbic regions to the neocortex : Clinical, radiological and pathological relationships. In: Dementia and Geriatric Cognitive Disorders. 1999 ; Vol. 10, No. 2. pp. 115-120.
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