The REDUCED(A RandomisED stUdy Comparing standard systemic anticoagulation thErapy to low Dose intracoronary anticoagulation therapy for elective percutaneous coronary intervention) trial. A novel pharmacologic regime for elective percutaneous coronary intervention

Hasan Ari, Eylem Kivaç, Selma Ari, Nadir Emlek, Seçkin Çetinkaya, Nuran Celiloğlu, O. Yasar Sarigul, Cihan Aydin, Mehmet Akkaya, Vedat Koca, Tahsin Bozat, Muhammet Gurdogan

Research output: Contribution to journalArticle

Abstract

Aim: This study tried to determine the efficacy and safety of low-dose intracoronary unfractionated heparin (UFH) in elective percutaneous coronary intervention (PCI). Methods: Two-hundred patients who underwent elective PCI of an uncomplicated lesion were included into the study. The patients were assigned to either a control group (70-100 IU/kg intravenous UFH) or a low-dose intracoronary UFH (1,000 IU intracoronary UFH) group. Results: At 30 days, the primary end point (composite of death, myocardial infarction, or urgent target vessel revascularization) was similar in both groups [intracoronary UFH group, 1.0%; control group, 2.0%; odds ratio; 0.49 (95% CI: 0.04 - 5.54), P = 0.56]. Post-procedural myocardial injury (according to CK-MB, P = 0.91; according to Tn I, P = 0.81) and bleeding events (based on TIMI criteria, P = 0.33; based on STEEPLE criteria, P = 0.20) were similar in the control and intracoronary groups. The primary end point at 6 months was also similar between the two groups (P = 0.33). Moreover, the health care cost at 30 days of follow-up was lower in the intracoronary group than in the control group (1,016 ± 54 $/patient vs 1,110 ± 102 $/patient, P < 0.001). Conclusion: This pilot study suggests that elective PCI could be safely performed with low-dose intracoronary UFH in the treatment of uncomplicated lesions and at a lower cost as compared to standard systemic anticoagulation. These results should be confirmed by further studies.

Original languageEnglish (US)
Pages (from-to)619-627
Number of pages9
JournalActa Cardiologica
Volume69
Issue number6
DOIs
StatePublished - Jan 1 2014

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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