Abstract
The objective of this study was to estimate the lifetime risk of breast cancer in women with a BRCA1 or BRCA2 mutation with and without at least 1 first-degree relative with breast cancer. A total of 2835 women with a BRCA1 or BRCA2 mutation were followed. Age- and gene-specific breast cancer rates were calculated. The relative risks of breast cancer for subjects with a family history of breast cancer, compared to no family history were calculated. The mean age at baseline was 41.1 years, and they were followed for a mean of 6.0 years. The estimated penetrance of breast cancer to age 80 years was 60.8% for BRCA1 and 63.1% for BRCA2. For all BRCA carriers, the penetrance of breast cancer to age 80 for those with no first-degree relative with breast cancer was 60.4% and 63.3% for those with at least 1 first-degree relative with breast cancer. The risk of breast cancer for BRCA carriers with no first-degree relative with breast cancer is substantial, and as a result, clinical management for these women should be the same as those for women with an affected relative.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1063-1068 |
| Number of pages | 6 |
| Journal | Clinical Genetics |
| Volume | 93 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2018 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
Cite this
The risk of breast cancer in BRCA1 and BRCA2 mutation carriers without a first-degree relative with breast cancer. / and the Hereditary Breast Cancer Clinical Study Group.
In: Clinical Genetics, Vol. 93, No. 5, 01.05.2018, p. 1063-1068.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The risk of breast cancer in BRCA1 and BRCA2 mutation carriers without a first-degree relative with breast cancer
AU - and the Hereditary Breast Cancer Clinical Study Group
AU - Metcalfe, K. A.
AU - Lubinski, J.
AU - Gronwald, J.
AU - Huzarski, T.
AU - McCuaig, J.
AU - Lynch, Henry T.
AU - Karlan, B.
AU - Foulkes, W. D.
AU - Singer, C. F.
AU - Neuhausen, S. L.
AU - Senter, L.
AU - Eisen, A.
AU - Sun, P.
AU - Narod, S. A.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - The objective of this study was to estimate the lifetime risk of breast cancer in women with a BRCA1 or BRCA2 mutation with and without at least 1 first-degree relative with breast cancer. A total of 2835 women with a BRCA1 or BRCA2 mutation were followed. Age- and gene-specific breast cancer rates were calculated. The relative risks of breast cancer for subjects with a family history of breast cancer, compared to no family history were calculated. The mean age at baseline was 41.1 years, and they were followed for a mean of 6.0 years. The estimated penetrance of breast cancer to age 80 years was 60.8% for BRCA1 and 63.1% for BRCA2. For all BRCA carriers, the penetrance of breast cancer to age 80 for those with no first-degree relative with breast cancer was 60.4% and 63.3% for those with at least 1 first-degree relative with breast cancer. The risk of breast cancer for BRCA carriers with no first-degree relative with breast cancer is substantial, and as a result, clinical management for these women should be the same as those for women with an affected relative.
AB - The objective of this study was to estimate the lifetime risk of breast cancer in women with a BRCA1 or BRCA2 mutation with and without at least 1 first-degree relative with breast cancer. A total of 2835 women with a BRCA1 or BRCA2 mutation were followed. Age- and gene-specific breast cancer rates were calculated. The relative risks of breast cancer for subjects with a family history of breast cancer, compared to no family history were calculated. The mean age at baseline was 41.1 years, and they were followed for a mean of 6.0 years. The estimated penetrance of breast cancer to age 80 years was 60.8% for BRCA1 and 63.1% for BRCA2. For all BRCA carriers, the penetrance of breast cancer to age 80 for those with no first-degree relative with breast cancer was 60.4% and 63.3% for those with at least 1 first-degree relative with breast cancer. The risk of breast cancer for BRCA carriers with no first-degree relative with breast cancer is substantial, and as a result, clinical management for these women should be the same as those for women with an affected relative.
UR - http://www.scopus.com/inward/record.url?scp=85044197589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044197589&partnerID=8YFLogxK
U2 - 10.1111/cge.13191
DO - 10.1111/cge.13191
M3 - Article
VL - 93
SP - 1063
EP - 1068
JO - Clinical Genetics
JF - Clinical Genetics
SN - 0009-9163
IS - 5
ER -