The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

Patrice Watson; Hans F.A. Vasen; J. P. Mecklin; Heikki Järvinen; Henry T. Lynch

doi:10.1016/0002-9343(94)90091-4

The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

Patrice Watson, Hans F.A. Vasen, J. P. Mecklin, Heikki Järvinen, Henry T. Lynch

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

194 Scopus citations

Abstract

PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P

Original language	English (US)
Pages (from-to)	516-520
Number of pages	5
Journal	The American Journal of Medicine
Volume	96
Issue number	6
DOIs	https://doi.org/10.1016/0002-9343(94)90091-4
State	Published - Jun 1994

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1016/0002-9343(94)90091-4

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@article{259cf9836d0e4e2d862b6b43d93a98f9,

title = "The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer",

abstract = "PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P ",

author = "Patrice Watson and Vasen, {Hans F.A.} and Mecklin, {J. P.} and Heikki J{\"a}rvinen and Lynch, {Henry T.}",

note = "Funding Information: This work was supported in part by grant #1297DRl from the Council for Tobacco Reseakch, USA, Inc. Reprint requests should be addressed to Patrice Watson, PhD, Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178.",

year = "1994",

month = jun,

doi = "10.1016/0002-9343(94)90091-4",

language = "English (US)",

volume = "96",

pages = "516--520",

journal = "American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

AU - Watson, Patrice

AU - Vasen, Hans F.A.

AU - Mecklin, J. P.

AU - Järvinen, Heikki

AU - Lynch, Henry T.

N1 - Funding Information: This work was supported in part by grant #1297DRl from the Council for Tobacco Reseakch, USA, Inc. Reprint requests should be addressed to Patrice Watson, PhD, Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178.

PY - 1994/6

Y1 - 1994/6

N2 - PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P

AB - PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P

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U2 - 10.1016/0002-9343(94)90091-4

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EP - 520

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 6

ER -

The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

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