The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

Patrice Watson, Hans F.A. Vasen, J. P. Mecklin, Heikki Järvinen, Henry T. Lynch

Research output: Contribution to journalArticlepeer-review

202 Scopus citations


PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P

Original languageEnglish (US)
Pages (from-to)516-520
Number of pages5
JournalThe American Journal of Medicine
Issue number6
StatePublished - Jun 1994

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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