The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

Patrice Watson, Hans F A Vasen, J. P. Mecklin, Heikki Järvinen, Henry T. Lynch

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P

Original languageEnglish
Pages (from-to)516-520
Number of pages5
JournalAmerican Journal of Medicine
Volume96
Issue number6
DOIs
StatePublished - 1994

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Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
Neoplasms
Life Tables
Neoplasm Genes
Colonic Neoplasms
Registries
Colorectal Neoplasms
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Nursing(all)

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The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. / Watson, Patrice; Vasen, Hans F A; Mecklin, J. P.; Järvinen, Heikki; Lynch, Henry T.

In: American Journal of Medicine, Vol. 96, No. 6, 1994, p. 516-520.

Research output: Contribution to journalArticle

Watson, Patrice ; Vasen, Hans F A ; Mecklin, J. P. ; Järvinen, Heikki ; Lynch, Henry T. / The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. In: American Journal of Medicine. 1994 ; Vol. 96, No. 6. pp. 516-520.
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