Abstract
PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P
| Original language | English |
|---|---|
| Pages (from-to) | 516-520 |
| Number of pages | 5 |
| Journal | American Journal of Medicine |
| Volume | 96 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1994 |
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All Science Journal Classification (ASJC) codes
- Nursing(all)
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The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. / Watson, Patrice; Vasen, Hans F A; Mecklin, J. P.; Järvinen, Heikki; Lynch, Henry T.
In: American Journal of Medicine, Vol. 96, No. 6, 1994, p. 516-520.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer
AU - Watson, Patrice
AU - Vasen, Hans F A
AU - Mecklin, J. P.
AU - Järvinen, Heikki
AU - Lynch, Henry T.
PY - 1994
Y1 - 1994
N2 - PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P
AB - PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P
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U2 - 10.1016/0002-9343(94)90091-4
DO - 10.1016/0002-9343(94)90091-4
M3 - Article
VL - 96
SP - 516
EP - 520
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 6
ER -