The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

Patrice Watson; Hans F A Vasen; J. P. Mecklin; Heikki Järvinen; Henry T. Lynch

doi:10.1016/0002-9343(94)90091-4

The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer

Patrice Watson, Hans F A Vasen, J. P. Mecklin, Heikki Järvinen, Henry T. Lynch

Department of Preventive Medicine

Research output: Contribution to journal › Article

193 Scopus citations

Abstract

PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P

Original language	English
Pages (from-to)	516-520
Number of pages	5
Journal	American Journal of Medicine
Volume	96
Issue number	6
DOIs	https://doi.org/10.1016/0002-9343(94)90091-4
Publication status	Published - 1994

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Watson, P., Vasen, H. F. A., Mecklin, J. P., Järvinen, H., & Lynch, H. T. (1994). The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. American Journal of Medicine, 96(6), 516-520. https://doi.org/10.1016/0002-9343(94)90091-4

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abstract = "PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20{\%} by age 70, compared to 3{\%} in the general population. Risk was highest in women most likely to carry the HNPCC gene (P",

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AU - Watson, Patrice

AU - Vasen, Hans F A

AU - Mecklin, J. P.

AU - Järvinen, Heikki

AU - Lynch, Henry T.

PY - 1994

Y1 - 1994

N2 - PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P

AB - PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by increased risk for cancer, especially colorectal cancer. It has been recommended that colon cancer control programs for family members be expanded to include endometrial cancer, the commonest extracolonic cancer observed in HNPCC families. We estimated the age-specific and cumulative endometrial cancer risk for women at high risk for HNPCC. PATIENTS AND METHODS: Family history data from three large HNPCC registries were combined for this study. High risk family members were identified without regard to extracolonic cancer. Life table methods were used to calculate estimates of risk. RESULTS: One thousand eighteen women from 86 families were included in the study. Cumulative incidence was 20% by age 70, compared to 3% in the general population. Risk was highest in women most likely to carry the HNPCC gene (P

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10.1016/0002-9343(94)90091-4