The role of empiric superior vena cava isolation in atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials

Sharan Prakash Sharma, Rajbir S. Sangha, Khagendra Dahal, Parasuram Krishnamoorthy

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Background: It is not clear whether additional empiric superior vena cava isolation (SVCI) to pulmonary vein isolation (PVI) results in low recurrences of atrial fibrillation. We aimed to perform a systematic review and meta-analysis of all randomized controlled trials (RCTs) that evaluated role of empiric SVCI in atrial fibrillation ablation. Methods: We searched PubMed, EMBASE, Cochrane, Scopus, and relevant references for RCTs (inception April 15, 2016 without language restrictions) and performed meta-analysis using random effects model. Recurrence rates of atrial fibrillations, procedural times, fluoroscopic times, and adverse events were the measured outcomes. Results: Three RCTs with a total population of 526 were analyzed. There was no difference in the recurrence rate between PVI plus SVCI versus PVI alone when comparison was made across all types of AF (39 vs 60; odds ratio 0.68; 95 % CI 0.43–1.07; P = 0.73; I2 = 0 %). When analysis was restricted only to paroxysmal AF, there was a trend towards low recurrence rate in combination group without statistical significance (19 vs 35, OR 0.54; 95 % CI 0.29–1.00; P = 0.05; I2 = 0). Similarly, no difference was noted between two groups in procedural (weighted mean difference [WMD] 10.12; 95 % CI −9.84 to 30.08; P = 0.32; I2 = 85 %) and fluoroscopic time (WMD 4.66; 95 % CI −0.92 to 10.25; P = 0.1; I2 = 94). Adverse events were similar in both groups. Conclusion: Empiric SVCI does not provide additional benefit to PVI alone for atrial fibrillation ablation.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalJournal of Interventional Cardiac Electrophysiology
Volume48
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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