The role of ganglioside GM3 in the modulation of conformation and activity of sarcoplasmic reticulum CA2+-ATPase

F. Y. Yang, L. H. Wang, X. Y. Yang, Z. C. Tsui, Yaping Tu

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Rabbit sarcoplasmic reticulum does contain trace amounts of gangliosides, and the main species is GM3. Incorporation of GM3 into the SR vesicles or addition of it to the soybean phospholipid used for reconstitution of proteoliposomes obviously increased ATP hydrolysis, as well as, Ca2+ uptake activity of sarcoplasmic reticulum Ca2+-ATPase. Conformation changes of Ca2+-ATPase induced by GM3 were also observed by circular dichroism, intrinsic fluorescence and fluorescence quenching measurements.

Original languageEnglish
Pages (from-to)137-146
Number of pages10
JournalBiophysical Chemistry
Issue number1-3
Publication statusPublished - Oct 1997
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Physical and Theoretical Chemistry

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