The role of ganglioside GM3 in the modulation of conformation and activity of sarcoplasmic reticulum CA2+-ATPase

F. Y. Yang, L. H. Wang, X. Y. Yang, Z. C. Tsui, Y. P. Tu

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Rabbit sarcoplasmic reticulum does contain trace amounts of gangliosides, and the main species is GM3. Incorporation of GM3 into the SR vesicles or addition of it to the soybean phospholipid used for reconstitution of proteoliposomes obviously increased ATP hydrolysis, as well as, Ca2+ uptake activity of sarcoplasmic reticulum Ca2+-ATPase. Conformation changes of Ca2+-ATPase induced by GM3 were also observed by circular dichroism, intrinsic fluorescence and fluorescence quenching measurements.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalBiophysical Chemistry
Volume68
Issue number1-3
DOIs
StatePublished - Oct 1 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Organic Chemistry

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