The role of ganglioside GM3 in the modulation of conformation and activity of sarcoplasmic reticulum CA2+-ATPase

F. Y. Yang; L. H. Wang; X. Y. Yang; Z. C. Tsui; Y. P. Tu

doi:10.1016/S0301-4622(97)00025-2

The role of ganglioside GM₃ in the modulation of conformation and activity of sarcoplasmic reticulum CA²⁺-ATPase

F. Y. Yang, L. H. Wang, X. Y. Yang, Z. C. Tsui, Y. P. Tu

Research output: Contribution to journal › Article

4 Scopus citations

Abstract

Rabbit sarcoplasmic reticulum does contain trace amounts of gangliosides, and the main species is GM₃. Incorporation of GM₃ into the SR vesicles or addition of it to the soybean phospholipid used for reconstitution of proteoliposomes obviously increased ATP hydrolysis, as well as, Ca²⁺ uptake activity of sarcoplasmic reticulum Ca²⁺-ATPase. Conformation changes of Ca²⁺-ATPase induced by GM₃ were also observed by circular dichroism, intrinsic fluorescence and fluorescence quenching measurements.

Original language	English (US)
Pages (from-to)	137-146
Number of pages	10
Journal	Biophysical Chemistry
Volume	68
Issue number	1-3
DOIs	https://doi.org/10.1016/S0301-4622(97)00025-2
State	Published - Oct 1 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Organic Chemistry

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Yang, F. Y., Wang, L. H., Yang, X. Y., Tsui, Z. C., & Tu, Y. P. (1997). The role of ganglioside GM₃ in the modulation of conformation and activity of sarcoplasmic reticulum CA²⁺-ATPase. Biophysical Chemistry, 68(1-3), 137-146. https://doi.org/10.1016/S0301-4622(97)00025-2

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