The role of genetics and host factors in cancer susceptibility and cancer resistance

Henry T. Lynch, H. A. Guirgis, P. M. Lynch, J. F. Lynch

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The genetics of cancer resistance and susceptibility has been the subject of intensive inquiry at the infra-human level, aided considerably by development of highly inbred animal strains. Findings from these studies have been applied to the testing of hypotheses about etiology and carcinogenesis in man. The present survey has briefly considered the way in which some familial cancer is distributed in human populations, demographic factors which contribute to variation in cancer susceptibility, and specific tissue susceptibility in hereditary cancer. Such examples as carcinoma of the breast, colon, von Recklinghausen's neurofibromatosis, and multiple primary malignant neoplasms emphasize these variables. With respect to multiple primaries, consideration has been given to the possible consequence of certain cancer therapies in those individuals who have a familial susceptibility to cancer. Problems in genetic heterogeneity, mechanisms involved in biological markers in cancer, and the phenomenon of cancer resistance have been discussed.

Original languageEnglish
Pages (from-to)175-224
Number of pages50
JournalCancer Detection and Prevention
Volume1
Issue number1
StatePublished - 1976

Fingerprint

Neoplasms
Inbred Strains Animals
Multiple Primary Neoplasms
Neurofibromatoses
Genetic Heterogeneity
Colon
Carcinogenesis
Biomarkers
Demography
Breast Neoplasms
Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

The role of genetics and host factors in cancer susceptibility and cancer resistance. / Lynch, Henry T.; Guirgis, H. A.; Lynch, P. M.; Lynch, J. F.

In: Cancer Detection and Prevention, Vol. 1, No. 1, 1976, p. 175-224.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Guirgis, H. A. ; Lynch, P. M. ; Lynch, J. F. / The role of genetics and host factors in cancer susceptibility and cancer resistance. In: Cancer Detection and Prevention. 1976 ; Vol. 1, No. 1. pp. 175-224.
@article{f19d65155c5348238def009067f00cf9,
title = "The role of genetics and host factors in cancer susceptibility and cancer resistance",
abstract = "The genetics of cancer resistance and susceptibility has been the subject of intensive inquiry at the infra-human level, aided considerably by development of highly inbred animal strains. Findings from these studies have been applied to the testing of hypotheses about etiology and carcinogenesis in man. The present survey has briefly considered the way in which some familial cancer is distributed in human populations, demographic factors which contribute to variation in cancer susceptibility, and specific tissue susceptibility in hereditary cancer. Such examples as carcinoma of the breast, colon, von Recklinghausen's neurofibromatosis, and multiple primary malignant neoplasms emphasize these variables. With respect to multiple primaries, consideration has been given to the possible consequence of certain cancer therapies in those individuals who have a familial susceptibility to cancer. Problems in genetic heterogeneity, mechanisms involved in biological markers in cancer, and the phenomenon of cancer resistance have been discussed.",
author = "Lynch, {Henry T.} and Guirgis, {H. A.} and Lynch, {P. M.} and Lynch, {J. F.}",
year = "1976",
language = "English",
volume = "1",
pages = "175--224",
journal = "Cancer Epidemiology",
issn = "1877-7821",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - The role of genetics and host factors in cancer susceptibility and cancer resistance

AU - Lynch, Henry T.

AU - Guirgis, H. A.

AU - Lynch, P. M.

AU - Lynch, J. F.

PY - 1976

Y1 - 1976

N2 - The genetics of cancer resistance and susceptibility has been the subject of intensive inquiry at the infra-human level, aided considerably by development of highly inbred animal strains. Findings from these studies have been applied to the testing of hypotheses about etiology and carcinogenesis in man. The present survey has briefly considered the way in which some familial cancer is distributed in human populations, demographic factors which contribute to variation in cancer susceptibility, and specific tissue susceptibility in hereditary cancer. Such examples as carcinoma of the breast, colon, von Recklinghausen's neurofibromatosis, and multiple primary malignant neoplasms emphasize these variables. With respect to multiple primaries, consideration has been given to the possible consequence of certain cancer therapies in those individuals who have a familial susceptibility to cancer. Problems in genetic heterogeneity, mechanisms involved in biological markers in cancer, and the phenomenon of cancer resistance have been discussed.

AB - The genetics of cancer resistance and susceptibility has been the subject of intensive inquiry at the infra-human level, aided considerably by development of highly inbred animal strains. Findings from these studies have been applied to the testing of hypotheses about etiology and carcinogenesis in man. The present survey has briefly considered the way in which some familial cancer is distributed in human populations, demographic factors which contribute to variation in cancer susceptibility, and specific tissue susceptibility in hereditary cancer. Such examples as carcinoma of the breast, colon, von Recklinghausen's neurofibromatosis, and multiple primary malignant neoplasms emphasize these variables. With respect to multiple primaries, consideration has been given to the possible consequence of certain cancer therapies in those individuals who have a familial susceptibility to cancer. Problems in genetic heterogeneity, mechanisms involved in biological markers in cancer, and the phenomenon of cancer resistance have been discussed.

UR - http://www.scopus.com/inward/record.url?scp=0017043594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017043594&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 175

EP - 224

JO - Cancer Epidemiology

JF - Cancer Epidemiology

SN - 1877-7821

IS - 1

ER -