The role of vitamin D in the pathogenesis and treatment of osteoporosis

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Abstract

It is well recognized that patients with postmenopausal osteoporosis usually exhibit some degree of calcium malabsorption and commonly have low serum concentrations of 1,25-dihydroxyvitamin D (calcitriol). Administration of calcitriol has been shown to normalize calcium absorption in patients with osteoporosis and, over the long term may have a stimulating effect on bone formation. Clinical trials have shown a significant reduction in osteoporotic fractures among calcitriol-treated patients. Hypercalcemia and hypercalciuria are infrequent complications of calcitriol therapy with physiologic doses (0.25 μg twice daily), and are most commonly related to excessive calcium intake (i.e., > 1000 mg daily).

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalJournal of Rheumatology
Volume23
Issue numberSUPPL. 45
StatePublished - Aug 1 1996

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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