It is well recognized that patients with postmenopausal osteoporosis usually exhibit some degree of calcium malabsorption and commonly have low serum concentrations of 1,25-dihydroxyvitamin D (calcitriol). Administration of calcitriol has been shown to normalize calcium absorption in patients with osteoporosis and, over the long term may have a stimulating effect on bone formation. Clinical trials have shown a significant reduction in osteoporotic fractures among calcitriol-treated patients. Hypercalcemia and hypercalciuria are infrequent complications of calcitriol therapy with physiologic doses (0.25 μg twice daily), and are most commonly related to excessive calcium intake (i.e., > 1000 mg daily).
|Number of pages||4|
|Journal||Journal of Rheumatology|
|Issue number||SUPPL. 45|
|Publication status||Published - Aug 1996|
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