The roles of sex steroid receptor coregulators in cancer

Xiuhua Gao, Brian W. Loggie, Zafar Nawaz

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

Sex steroid hormones, estrogen, progesterone and androgen, play pivotal roles in sex differentiation and development, and in reproductive functions and sexual behavior. Studies have shown that sex steroid hormones are the key regulators in the development and progression of endocrine-related cancers, especially the cancers of the reproductive tissues. The actions of estrogen, progesterone and androgen are mediated through their cognate intracellular receptor proteins, the estrogen receptors (ER), the progesterone receptors (PR) and the androgen receptor (AR), respectively. These receptors are members of the nuclear receptor (NR) superfamily, which function as transcription factors that regulate their target gene expression. Proper functioning of these steroid receptors maintains the normal responsiveness of the target tissues to the stimulations of the steroid hormones. This permits the normal development and function of reproductive tissues. It can be inferred that factors influencing the expression or function of steroid receptors will interfere with the normal development and function of the target tissues, and may induce pathological conditions, including cancers. In addition to the direct contact with the basal transcription machinery, nuclear receptors enhance or suppress transcription by recruiting an array of coactivators and corepressors, collectively named coregulators. Therefore, the mutation or aberrant expression of sex steroid receptor coregulators will affect the normal function of the sex steroid receptors and hence may participate in the development and progression of the cancers.

Original languageEnglish
Article number7
JournalMolecular Cancer
Volume1
DOIs
StatePublished - Nov 14 2002

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Steroid Receptors
Tissue
Gonadal Steroid Hormones
Cytoplasmic and Nuclear Receptors
Androgens
Progesterone
Transcription
Neoplasms
Estrogens
Endocrine Gland Neoplasms
Reproductive Behavior
Co-Repressor Proteins
Sex Differentiation
Sexual Development
Steroid hormones
Androgen Receptors
Progesterone Receptors
Sexual Behavior
Transcription Factors
Gene expression

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Cancer Research
  • Molecular Medicine

Cite this

The roles of sex steroid receptor coregulators in cancer. / Gao, Xiuhua; Loggie, Brian W.; Nawaz, Zafar.

In: Molecular Cancer, Vol. 1, 7, 14.11.2002.

Research output: Contribution to journalReview article

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