Abstract
We studied two children who had rhabdomyosarcoma and glioblastoma and who were from a family with a hereditary cancer syndrome that was characterized by sarcoma, breast cancer, brain tumors, lung cancer, laryngeal carcinoma, leukemia, and adrenocortical carcinoma. The deleterious genotype has now been expressed through the fourth generation of this large kindred. The pedigree emphasizes the need for an extended history of several generations to arrive at a hereditary-syndrome diagnosis. A limited pedigree may result in nonappreciation of the genetic component. The pedigree illustrates that, in certain circumstances, the highly specific varieties of cancer may occur in children before it is expressed in the parent who carries the putative gene. Pediatricians, in evaluating the causes of childhood cancer, must be cognizant of cancer among adult relatives, since this recognition may aid in the diagnosis of those hereditary cancer syndromes that are characterized by cancer occurrence in children as well as adults.
| Original language | English |
|---|---|
| Pages (from-to) | 134-136 |
| Number of pages | 3 |
| Journal | American Journal of Diseases of Children |
| Volume | 139 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
Cite this
The Sarcoma, Breast Cancer, Lung Cancer, and Adrenocortical Carcinoma Syndrome Revisited : Childhood Cancer. / Lynch, Henry T.; Katz, David A.; Bogard, Patrick J.; Lynch, Jane F.
In: American Journal of Diseases of Children, Vol. 139, No. 2, 1985, p. 134-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Sarcoma, Breast Cancer, Lung Cancer, and Adrenocortical Carcinoma Syndrome Revisited
T2 - Childhood Cancer
AU - Lynch, Henry T.
AU - Katz, David A.
AU - Bogard, Patrick J.
AU - Lynch, Jane F.
PY - 1985
Y1 - 1985
N2 - We studied two children who had rhabdomyosarcoma and glioblastoma and who were from a family with a hereditary cancer syndrome that was characterized by sarcoma, breast cancer, brain tumors, lung cancer, laryngeal carcinoma, leukemia, and adrenocortical carcinoma. The deleterious genotype has now been expressed through the fourth generation of this large kindred. The pedigree emphasizes the need for an extended history of several generations to arrive at a hereditary-syndrome diagnosis. A limited pedigree may result in nonappreciation of the genetic component. The pedigree illustrates that, in certain circumstances, the highly specific varieties of cancer may occur in children before it is expressed in the parent who carries the putative gene. Pediatricians, in evaluating the causes of childhood cancer, must be cognizant of cancer among adult relatives, since this recognition may aid in the diagnosis of those hereditary cancer syndromes that are characterized by cancer occurrence in children as well as adults.
AB - We studied two children who had rhabdomyosarcoma and glioblastoma and who were from a family with a hereditary cancer syndrome that was characterized by sarcoma, breast cancer, brain tumors, lung cancer, laryngeal carcinoma, leukemia, and adrenocortical carcinoma. The deleterious genotype has now been expressed through the fourth generation of this large kindred. The pedigree emphasizes the need for an extended history of several generations to arrive at a hereditary-syndrome diagnosis. A limited pedigree may result in nonappreciation of the genetic component. The pedigree illustrates that, in certain circumstances, the highly specific varieties of cancer may occur in children before it is expressed in the parent who carries the putative gene. Pediatricians, in evaluating the causes of childhood cancer, must be cognizant of cancer among adult relatives, since this recognition may aid in the diagnosis of those hereditary cancer syndromes that are characterized by cancer occurrence in children as well as adults.
UR - http://www.scopus.com/inward/record.url?scp=0021964259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021964259&partnerID=8YFLogxK
U2 - 10.1001/archpedi.1985.02140040032020
DO - 10.1001/archpedi.1985.02140040032020
M3 - Article
C2 - 3976585
AN - SCOPUS:0021964259
VL - 139
SP - 134
EP - 136
JO - JAMA Pediatrics
JF - JAMA Pediatrics
SN - 2168-6203
IS - 2
ER -