The scope of bacterial resistance to antibiotics in some countries in the middle East and North Africa

Noha Gamal Khalaf, Nancy D. Hanson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Data available on bacterial resistance to antibiotics in the Middle East and some African countries mainly comprised sporadic nosocomial outbreaks. However, some surveillance studies, such as the PEARLS and ARMed have examined resistance determinants and patterns of common nosocomial pathogens in some Middle Eastern and North African countries. But no national surveillance figures have been published in any of these individual countries. In this chapter we will present reported rates of bacterial resistance to antibiotics in clinically important pathogens such as MRSA, Escherichia coli and other selected Enterobacteriaceae in this geographical region. In addition, we will discuss studies on nosocomial pathogens notorious for multidrug resistance such as Acinetobacter baumannii, Pseudomonas aeruginosa, as well as ESBL producers of the Enterobacteriaceae that are prevalent in some Middle Eastern and African countries. These clinically important pathogens were reported to possess various ESBL genes of the TEM-, SHV-, CTX-M-families; as well as the carbapenem hydrolyzing metallo-and OXA-type β-lactamases. Other resistance determinants were also reported and include the integron associated qnr gene, and the aac (6')-Ib-cr gene which codes for aminoglycoside resistance and reduced susceptibility to ciprofloxacin. In addition, community acquired infections caused by MRSA and ESBL producers of the Enterobacteriaceae that have been reported in this geographical region will be covered. Because of the disturbing high rates of bacterial resistance to antibiotics in this geographical region, some countries found it compelling to initiate Infection Control programs to hamper the spread of resistant pathogens.

Original languageEnglish
Title of host publicationMultidrug Resistance A Global Concern
PublisherBentham Science Publishers Ltd.
Pages176-205
Number of pages30
ISBN (Print)9781608052554
DOIs
StatePublished - 2012

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Bacterial Drug Resistance
Northern Africa
Eastern Africa
Middle East
Enterobacteriaceae
Methicillin-Resistant Staphylococcus aureus
Integrons
Genes
Community-Acquired Infections
Acinetobacter baumannii
Carbapenems
Multiple Drug Resistance
Aminoglycosides
Ciprofloxacin
Infection Control
Pseudomonas aeruginosa
Disease Outbreaks
Escherichia coli

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Khalaf, N. G., & Hanson, N. D. (2012). The scope of bacterial resistance to antibiotics in some countries in the middle East and North Africa. In Multidrug Resistance A Global Concern (pp. 176-205). Bentham Science Publishers Ltd.. https://doi.org/10.2174/978160805292911201010176

The scope of bacterial resistance to antibiotics in some countries in the middle East and North Africa. / Khalaf, Noha Gamal; Hanson, Nancy D.

Multidrug Resistance A Global Concern. Bentham Science Publishers Ltd., 2012. p. 176-205.

Research output: Chapter in Book/Report/Conference proceedingChapter

Khalaf, Noha Gamal ; Hanson, Nancy D. / The scope of bacterial resistance to antibiotics in some countries in the middle East and North Africa. Multidrug Resistance A Global Concern. Bentham Science Publishers Ltd., 2012. pp. 176-205
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