@inbook{99a43cd4e2484e4396b6763bf352e2e7,
title = "The structural and functional uniqueness of the glmS ribozyme",
abstract = "The glmS bacterial ribozyme/riboswitch is found in a number of Gram-positive bacteria, many of which are human pathogens. Investigation of the structure and function of the glmS catalyst will aid in the development of artificial agonists/antagonists that might function as novel antibiotics. The glmS ribozyme is mechanistically unique in that it is the first RNA catalyst identified to require a coenzyme, glucosamine-6-phosphate, for RNA self-cleavage. In addition, it is the first riboswitch identified to utilize self-cleavage as a mode of genetic regulation in metabolism. Significant biochemical and biophysical data exist for the glmS ribozyme and aid in mechanistically understanding the importance of RNA and coenzyme structure to function in acid-base catalysis.",
author = "Soukup, {Juliane K.}",
note = "Funding Information: I wish to thank Mark and Kay Delaney for their generous donation to my laboratory. This publication was made possible by grants from the National Center for Research Resources (5P20RR016469) and the National Institute for General Medical Science (NIGMS) (5P20GM103427 and R15M083641), a component of the National Institutes of Health (NIH) and its contents are the sole responsibility of the authors and do not necessarily represent the official views of NIGMS or NIH. J. K. S. was supported by the Clare Boothe Luce Endowed Chair for Women in Science, funded by the Luce Foundation. ",
year = "2013",
doi = "10.1016/B978-0-12-381286-5.00005-6",
language = "English (US)",
isbn = "9780123812865",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
pages = "173--193",
booktitle = "Catalytic RNA",
}