The structural and functional uniqueness of the glmS ribozyme

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

The glmS bacterial ribozyme/riboswitch is found in a number of Gram-positive bacteria, many of which are human pathogens. Investigation of the structure and function of the glmS catalyst will aid in the development of artificial agonists/antagonists that might function as novel antibiotics. The glmS ribozyme is mechanistically unique in that it is the first RNA catalyst identified to require a coenzyme, glucosamine-6-phosphate, for RNA self-cleavage. In addition, it is the first riboswitch identified to utilize self-cleavage as a mode of genetic regulation in metabolism. Significant biochemical and biophysical data exist for the glmS ribozyme and aid in mechanistically understanding the importance of RNA and coenzyme structure to function in acid-base catalysis.

Original languageEnglish
Title of host publicationCatalytic RNA
PublisherElsevier
Pages173-193
Number of pages21
Volume120
ISBN (Print)9780123812865
DOIs
StatePublished - 2013

Publication series

NameProgress in Molecular Biology and Translational Science
Volume120
ISSN (Print)18771173

Fingerprint

Catalytic RNA
Riboswitch
Coenzymes
RNA Cleavage
RNA
Gram-Positive Bacteria
Catalysis
Anti-Bacterial Agents
Acids

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Molecular Medicine

Cite this

Strauss-Soukup, J. K. (2013). The structural and functional uniqueness of the glmS ribozyme. In Catalytic RNA (Vol. 120, pp. 173-193). (Progress in Molecular Biology and Translational Science; Vol. 120). Elsevier. https://doi.org/10.1016/B978-0-12-381286-5.00005-6

The structural and functional uniqueness of the glmS ribozyme. / Strauss-Soukup, Juliane K.

Catalytic RNA. Vol. 120 Elsevier, 2013. p. 173-193 (Progress in Molecular Biology and Translational Science; Vol. 120).

Research output: Chapter in Book/Report/Conference proceedingChapter

Strauss-Soukup, JK 2013, The structural and functional uniqueness of the glmS ribozyme. in Catalytic RNA. vol. 120, Progress in Molecular Biology and Translational Science, vol. 120, Elsevier, pp. 173-193. https://doi.org/10.1016/B978-0-12-381286-5.00005-6
Strauss-Soukup JK. The structural and functional uniqueness of the glmS ribozyme. In Catalytic RNA. Vol. 120. Elsevier. 2013. p. 173-193. (Progress in Molecular Biology and Translational Science). https://doi.org/10.1016/B978-0-12-381286-5.00005-6
Strauss-Soukup, Juliane K. / The structural and functional uniqueness of the glmS ribozyme. Catalytic RNA. Vol. 120 Elsevier, 2013. pp. 173-193 (Progress in Molecular Biology and Translational Science).
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