The structural and functional uniqueness of the glmS ribozyme

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The glmS bacterial ribozyme/riboswitch is found in a number of Gram-positive bacteria, many of which are human pathogens. Investigation of the structure and function of the glmS catalyst will aid in the development of artificial agonists/antagonists that might function as novel antibiotics. The glmS ribozyme is mechanistically unique in that it is the first RNA catalyst identified to require a coenzyme, glucosamine-6-phosphate, for RNA self-cleavage. In addition, it is the first riboswitch identified to utilize self-cleavage as a mode of genetic regulation in metabolism. Significant biochemical and biophysical data exist for the glmS ribozyme and aid in mechanistically understanding the importance of RNA and coenzyme structure to function in acid-base catalysis.

Original languageEnglish (US)
Title of host publicationCatalytic RNA
PublisherElsevier B.V.
Pages173-193
Number of pages21
ISBN (Print)9780123812865
DOIs
StatePublished - Jan 1 2013

Publication series

NameProgress in Molecular Biology and Translational Science
Volume120
ISSN (Print)1877-1173

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

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    Soukup, J. K. (2013). The structural and functional uniqueness of the glmS ribozyme. In Catalytic RNA (pp. 173-193). (Progress in Molecular Biology and Translational Science; Vol. 120). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-381286-5.00005-6