The study of skeletal calcium metabolism with 41Ca and 45Ca

Stewart P H T Freeman, Belinda Beck, June M. Bierman, Marc W. Caffee, Robert P. Heaney, Leah Holloway, Robert Marcus, John R. Southon, John S. Vogel

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The living skeleton can be labeled for life by the administration of radiologically trivial amounts of 41Ca tracer. After initial elimination of tracer from the readily exchangeable calcium pools subsequent skeletal calcium turnover maintains and modulates the urine 41Ca content. Uniquely, bone calcium metabolism may then be studied with tracer in near equilibrium with the body's calcium and resorbing calcium directly measured by accelerator mass spectrometry (AMS) of excreta. Our experiments with 25 41Ca labeled subjects demonstrate excellent diurnal stability and remarkable response to intervention of the urine signal. Thus the tracer method may prove a competitive means of measuring the effects of antiresorptive osteoporosis treatments, for therapy development or even clinical monitoring. Novel studies of long-term skeletal evolution are also possible. We realize that routinely administered short-lived calcium radiotracers contain 41Ca impurities and that thousands of experimental participants have been historically inadvertently 41Ca labeled. The 41Ca urine index might now rapidly further be characterized by contemporary measurements of these one-time subjects, and with their by now thoroughly skeleton-equilibrated tracer they might be ideal participants in other new experiments. We are also investigating 45Ca AMS. It may prove preferable to label the skeleton with this radiotracer already familiar to bioscientists, but new to AMS.

Original languageEnglish
Pages (from-to)930-933
Number of pages4
JournalNuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume172
Issue number1-4
StatePublished - 2000

Fingerprint

calcium metabolism
Metabolism
tracers
calcium
Calcium
urine
musculoskeletal system
accelerators
mass spectroscopy
Particle accelerators
Mass spectrometry
osteoporosis
bones
elimination
therapy
Labels
Bone
impurities
Experiments
Impurities

All Science Journal Classification (ASJC) codes

  • Surfaces, Coatings and Films
  • Instrumentation
  • Surfaces and Interfaces

Cite this

Freeman, S. P. H. T., Beck, B., Bierman, J. M., Caffee, M. W., Heaney, R. P., Holloway, L., ... Vogel, J. S. (2000). The study of skeletal calcium metabolism with 41Ca and 45Ca. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 172(1-4), 930-933.

The study of skeletal calcium metabolism with 41Ca and 45Ca. / Freeman, Stewart P H T; Beck, Belinda; Bierman, June M.; Caffee, Marc W.; Heaney, Robert P.; Holloway, Leah; Marcus, Robert; Southon, John R.; Vogel, John S.

In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, Vol. 172, No. 1-4, 2000, p. 930-933.

Research output: Contribution to journalArticle

Freeman, SPHT, Beck, B, Bierman, JM, Caffee, MW, Heaney, RP, Holloway, L, Marcus, R, Southon, JR & Vogel, JS 2000, 'The study of skeletal calcium metabolism with 41Ca and 45Ca', Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 172, no. 1-4, pp. 930-933.
Freeman, Stewart P H T ; Beck, Belinda ; Bierman, June M. ; Caffee, Marc W. ; Heaney, Robert P. ; Holloway, Leah ; Marcus, Robert ; Southon, John R. ; Vogel, John S. / The study of skeletal calcium metabolism with 41Ca and 45Ca. In: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. 2000 ; Vol. 172, No. 1-4. pp. 930-933.
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