Abstract
We studied rhesus monkeys with hemiparkinsonism or bilateral parkinsonism produced by unilateral or bilateral intracarotid administration of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine. Using a standardized clinical rating scale, 4 hemiparkinsonian monkeys showed a 13 to 56% (mean, 36%) spontaneous improvement during an obsevation period of up to 25 weeks. Generally, recovery leveled off after 14 weeks. Four bilaterally parkinsonian monkeys showed a 5 to 42%(mean, 22percnt;) improvement over a period of up to 30 weeks. Our findings emphasize that spontaneous recovery is a potentially confounding characteristic of this monkey model when used for assessing novel antiparkinsonian therapies.
Original language | English (US) |
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Pages (from-to) | 677-679 |
Number of pages | 3 |
Journal | Annals of Neurology |
Volume | 29 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1991 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology