The transcriptional landscape of the mammalian genome.

P. Carninci, T. Kasukawa, S. Katayama, J. Gough, M. C. Frith, N. Maeda, R. Oyama, T. Ravasi, B. Lenhard, C. Wells, R. Kodzius, K. Shimokawa, V. B. Bajic, S. E. Brenner, S. Batalov, A. R R Forrest, M. Zavolan, M. J. Davis, L. G. Wilming, V. AidinisJ. E. Allen, A. Ambesi-Impiombato, R. Apweiler, R. N. Aturaliya, T. L. Bailey, M. Bansal, L. Baxter, Kirk Beisel, T. Bersano, H. Bono, A. M. Chalk, K. P. Chiu, V. Choudhary, A. Christoffels, D. R. Clutterbuck, M. L. Crowe, E. Dalla, B. P. Dalrymple, B. de Bono, G. della Gatta, D. di Bernardo, T. Down, P. Engstrom, M. Fagiolini, G. Faulkner, C. F. Fletcher, T. Fukushima, M. Furuno, S. Futaki, M. Gariboldi, P. Georgii-Hemming, T. R. Gingeras, T. Gojobori, R. E. Green, S. Gustincich, M. Harbers, Y. Hayashi, T. K. Hensch, N. Hirokawa, D. Hill, L. Huminiecki, M. Iacono, K. Ikeo, A. Iwama, T. Ishikawa, M. Jakt, A. Kanapin, M. Katoh, Y. Kawasawa, J. Kelso, H. Kitamura, H. Kitano, G. Kollias, S. P T Krishnan, A. F. Kruger, S. K. Kummerfeld, I. V. Kurochkin, L. F. Lareau, D. Lazarevic, L. Lipovich, J. Liu, S. Liuni, S. McWilliam, M. Madan Babu, M. Madera, L. Marchionni, H. Matsuda, S. Matsuzawa, H. Miki, F. Mignone, S. Miyake, K. Morris, S. Mottagui-Tabar, N. Mulder, N. Nakano, H. Nakauchi, P. Ng, R. Nilsson, S. Nishiguchi, S. Nishikawa, F. Nori, O. Ohara, Y. Okazaki, V. Orlando, K. C. Pang, W. J. Pavan, G. Pavesi, G. Pesole, N. Petrovsky, S. Piazza, J. Reed, J. F. Reid, B. Z. Ring, M. Ringwald, B. Rost, Y. Ruan, S. L. Salzberg, A. Sandelin, C. Schneider, C. Schönbach, K. Sekiguchi, C. A M Semple, S. Seno, L. Sessa, Y. Sheng, Y. Shibata, H. Shimada, K. Shimada, D. Silva, B. Sinclair, S. Sperling, E. Stupka, K. Sugiura, R. Sultana, Y. Takenaka, K. Taki, K. Tammoja, S. L. Tan, S. Tang, M. S. Taylor, J. Tegner, S. A. Teichmann, H. R. Ueda, E. van Nimwegene, R. Verardo, C. L. Wei, K. Yagi, H. Yamanishi, E. Zabarovsky, S. Zhu, A. Zimmer, W. Hide, C. Bult, S. M. Grimmond, R. D. Teasdale, E. T. Liu, V. Brusic, J. Quackenbush, C. Wahlestedt, J. S. Mattick, D. A. Hume, C. Kai, D. Sasaki, Y. Tomaru, S. Fukuda, M. Kanamori-Katayama, M. Suzuki, J. Aoki, T. Arakawa, J. Iida, K. Imamura, M. Itoh, T. Kato, H. Kawaji, N. Kawagashira, T. Kawashima, M. Kojima, S. Kondo, H. Konno, K. Nakano, N. Ninomiya, T. Nishio, M. Okada, C. Plessy, K. Shibata, T. Shiraki, S. Suzuki, M. Tagami, K. Waki, A. Watahiki, Y. Okamura-Oho, H. Suzuki, J. Kawai, Y. Hayashizaki

Research output: Contribution to journalArticle

2244 Citations (Scopus)

Abstract

This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

Original languageEnglish
Pages (from-to)1559-1563
Number of pages5
JournalScience
Volume309
Issue number5740
StatePublished - Sep 2 2005

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Genome
Polyadenylation
Transcription Initiation Site
Transcriptome
Proteins
Complementary DNA
Forests

All Science Journal Classification (ASJC) codes

  • General

Cite this

Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M. C., Maeda, N., ... Hayashizaki, Y. (2005). The transcriptional landscape of the mammalian genome. Science, 309(5740), 1559-1563.

The transcriptional landscape of the mammalian genome. / Carninci, P.; Kasukawa, T.; Katayama, S.; Gough, J.; Frith, M. C.; Maeda, N.; Oyama, R.; Ravasi, T.; Lenhard, B.; Wells, C.; Kodzius, R.; Shimokawa, K.; Bajic, V. B.; Brenner, S. E.; Batalov, S.; Forrest, A. R R; Zavolan, M.; Davis, M. J.; Wilming, L. G.; Aidinis, V.; Allen, J. E.; Ambesi-Impiombato, A.; Apweiler, R.; Aturaliya, R. N.; Bailey, T. L.; Bansal, M.; Baxter, L.; Beisel, Kirk; Bersano, T.; Bono, H.; Chalk, A. M.; Chiu, K. P.; Choudhary, V.; Christoffels, A.; Clutterbuck, D. R.; Crowe, M. L.; Dalla, E.; Dalrymple, B. P.; de Bono, B.; della Gatta, G.; di Bernardo, D.; Down, T.; Engstrom, P.; Fagiolini, M.; Faulkner, G.; Fletcher, C. F.; Fukushima, T.; Furuno, M.; Futaki, S.; Gariboldi, M.; Georgii-Hemming, P.; Gingeras, T. R.; Gojobori, T.; Green, R. E.; Gustincich, S.; Harbers, M.; Hayashi, Y.; Hensch, T. K.; Hirokawa, N.; Hill, D.; Huminiecki, L.; Iacono, M.; Ikeo, K.; Iwama, A.; Ishikawa, T.; Jakt, M.; Kanapin, A.; Katoh, M.; Kawasawa, Y.; Kelso, J.; Kitamura, H.; Kitano, H.; Kollias, G.; Krishnan, S. P T; Kruger, A. F.; Kummerfeld, S. K.; Kurochkin, I. V.; Lareau, L. F.; Lazarevic, D.; Lipovich, L.; Liu, J.; Liuni, S.; McWilliam, S.; Madan Babu, M.; Madera, M.; Marchionni, L.; Matsuda, H.; Matsuzawa, S.; Miki, H.; Mignone, F.; Miyake, S.; Morris, K.; Mottagui-Tabar, S.; Mulder, N.; Nakano, N.; Nakauchi, H.; Ng, P.; Nilsson, R.; Nishiguchi, S.; Nishikawa, S.; Nori, F.; Ohara, O.; Okazaki, Y.; Orlando, V.; Pang, K. C.; Pavan, W. J.; Pavesi, G.; Pesole, G.; Petrovsky, N.; Piazza, S.; Reed, J.; Reid, J. F.; Ring, B. Z.; Ringwald, M.; Rost, B.; Ruan, Y.; Salzberg, S. L.; Sandelin, A.; Schneider, C.; Schönbach, C.; Sekiguchi, K.; Semple, C. A M; Seno, S.; Sessa, L.; Sheng, Y.; Shibata, Y.; Shimada, H.; Shimada, K.; Silva, D.; Sinclair, B.; Sperling, S.; Stupka, E.; Sugiura, K.; Sultana, R.; Takenaka, Y.; Taki, K.; Tammoja, K.; Tan, S. L.; Tang, S.; Taylor, M. S.; Tegner, J.; Teichmann, S. A.; Ueda, H. R.; van Nimwegene, E.; Verardo, R.; Wei, C. L.; Yagi, K.; Yamanishi, H.; Zabarovsky, E.; Zhu, S.; Zimmer, A.; Hide, W.; Bult, C.; Grimmond, S. M.; Teasdale, R. D.; Liu, E. T.; Brusic, V.; Quackenbush, J.; Wahlestedt, C.; Mattick, J. S.; Hume, D. A.; Kai, C.; Sasaki, D.; Tomaru, Y.; Fukuda, S.; Kanamori-Katayama, M.; Suzuki, M.; Aoki, J.; Arakawa, T.; Iida, J.; Imamura, K.; Itoh, M.; Kato, T.; Kawaji, H.; Kawagashira, N.; Kawashima, T.; Kojima, M.; Kondo, S.; Konno, H.; Nakano, K.; Ninomiya, N.; Nishio, T.; Okada, M.; Plessy, C.; Shibata, K.; Shiraki, T.; Suzuki, S.; Tagami, M.; Waki, K.; Watahiki, A.; Okamura-Oho, Y.; Suzuki, H.; Kawai, J.; Hayashizaki, Y.

In: Science, Vol. 309, No. 5740, 02.09.2005, p. 1559-1563.

Research output: Contribution to journalArticle

Carninci, P, Kasukawa, T, Katayama, S, Gough, J, Frith, MC, Maeda, N, Oyama, R, Ravasi, T, Lenhard, B, Wells, C, Kodzius, R, Shimokawa, K, Bajic, VB, Brenner, SE, Batalov, S, Forrest, ARR, Zavolan, M, Davis, MJ, Wilming, LG, Aidinis, V, Allen, JE, Ambesi-Impiombato, A, Apweiler, R, Aturaliya, RN, Bailey, TL, Bansal, M, Baxter, L, Beisel, K, Bersano, T, Bono, H, Chalk, AM, Chiu, KP, Choudhary, V, Christoffels, A, Clutterbuck, DR, Crowe, ML, Dalla, E, Dalrymple, BP, de Bono, B, della Gatta, G, di Bernardo, D, Down, T, Engstrom, P, Fagiolini, M, Faulkner, G, Fletcher, CF, Fukushima, T, Furuno, M, Futaki, S, Gariboldi, M, Georgii-Hemming, P, Gingeras, TR, Gojobori, T, Green, RE, Gustincich, S, Harbers, M, Hayashi, Y, Hensch, TK, Hirokawa, N, Hill, D, Huminiecki, L, Iacono, M, Ikeo, K, Iwama, A, Ishikawa, T, Jakt, M, Kanapin, A, Katoh, M, Kawasawa, Y, Kelso, J, Kitamura, H, Kitano, H, Kollias, G, Krishnan, SPT, Kruger, AF, Kummerfeld, SK, Kurochkin, IV, Lareau, LF, Lazarevic, D, Lipovich, L, Liu, J, Liuni, S, McWilliam, S, Madan Babu, M, Madera, M, Marchionni, L, Matsuda, H, Matsuzawa, S, Miki, H, Mignone, F, Miyake, S, Morris, K, Mottagui-Tabar, S, Mulder, N, Nakano, N, Nakauchi, H, Ng, P, Nilsson, R, Nishiguchi, S, Nishikawa, S, Nori, F, Ohara, O, Okazaki, Y, Orlando, V, Pang, KC, Pavan, WJ, Pavesi, G, Pesole, G, Petrovsky, N, Piazza, S, Reed, J, Reid, JF, Ring, BZ, Ringwald, M, Rost, B, Ruan, Y, Salzberg, SL, Sandelin, A, Schneider, C, Schönbach, C, Sekiguchi, K, Semple, CAM, Seno, S, Sessa, L, Sheng, Y, Shibata, Y, Shimada, H, Shimada, K, Silva, D, Sinclair, B, Sperling, S, Stupka, E, Sugiura, K, Sultana, R, Takenaka, Y, Taki, K, Tammoja, K, Tan, SL, Tang, S, Taylor, MS, Tegner, J, Teichmann, SA, Ueda, HR, van Nimwegene, E, Verardo, R, Wei, CL, Yagi, K, Yamanishi, H, Zabarovsky, E, Zhu, S, Zimmer, A, Hide, W, Bult, C, Grimmond, SM, Teasdale, RD, Liu, ET, Brusic, V, Quackenbush, J, Wahlestedt, C, Mattick, JS, Hume, DA, Kai, C, Sasaki, D, Tomaru, Y, Fukuda, S, Kanamori-Katayama, M, Suzuki, M, Aoki, J, Arakawa, T, Iida, J, Imamura, K, Itoh, M, Kato, T, Kawaji, H, Kawagashira, N, Kawashima, T, Kojima, M, Kondo, S, Konno, H, Nakano, K, Ninomiya, N, Nishio, T, Okada, M, Plessy, C, Shibata, K, Shiraki, T, Suzuki, S, Tagami, M, Waki, K, Watahiki, A, Okamura-Oho, Y, Suzuki, H, Kawai, J & Hayashizaki, Y 2005, 'The transcriptional landscape of the mammalian genome.', Science, vol. 309, no. 5740, pp. 1559-1563.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N et al. The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-1563.
Carninci, P. ; Kasukawa, T. ; Katayama, S. ; Gough, J. ; Frith, M. C. ; Maeda, N. ; Oyama, R. ; Ravasi, T. ; Lenhard, B. ; Wells, C. ; Kodzius, R. ; Shimokawa, K. ; Bajic, V. B. ; Brenner, S. E. ; Batalov, S. ; Forrest, A. R R ; Zavolan, M. ; Davis, M. J. ; Wilming, L. G. ; Aidinis, V. ; Allen, J. E. ; Ambesi-Impiombato, A. ; Apweiler, R. ; Aturaliya, R. N. ; Bailey, T. L. ; Bansal, M. ; Baxter, L. ; Beisel, Kirk ; Bersano, T. ; Bono, H. ; Chalk, A. M. ; Chiu, K. P. ; Choudhary, V. ; Christoffels, A. ; Clutterbuck, D. R. ; Crowe, M. L. ; Dalla, E. ; Dalrymple, B. P. ; de Bono, B. ; della Gatta, G. ; di Bernardo, D. ; Down, T. ; Engstrom, P. ; Fagiolini, M. ; Faulkner, G. ; Fletcher, C. F. ; Fukushima, T. ; Furuno, M. ; Futaki, S. ; Gariboldi, M. ; Georgii-Hemming, P. ; Gingeras, T. R. ; Gojobori, T. ; Green, R. E. ; Gustincich, S. ; Harbers, M. ; Hayashi, Y. ; Hensch, T. K. ; Hirokawa, N. ; Hill, D. ; Huminiecki, L. ; Iacono, M. ; Ikeo, K. ; Iwama, A. ; Ishikawa, T. ; Jakt, M. ; Kanapin, A. ; Katoh, M. ; Kawasawa, Y. ; Kelso, J. ; Kitamura, H. ; Kitano, H. ; Kollias, G. ; Krishnan, S. P T ; Kruger, A. F. ; Kummerfeld, S. K. ; Kurochkin, I. V. ; Lareau, L. F. ; Lazarevic, D. ; Lipovich, L. ; Liu, J. ; Liuni, S. ; McWilliam, S. ; Madan Babu, M. ; Madera, M. ; Marchionni, L. ; Matsuda, H. ; Matsuzawa, S. ; Miki, H. ; Mignone, F. ; Miyake, S. ; Morris, K. ; Mottagui-Tabar, S. ; Mulder, N. ; Nakano, N. ; Nakauchi, H. ; Ng, P. ; Nilsson, R. ; Nishiguchi, S. ; Nishikawa, S. ; Nori, F. ; Ohara, O. ; Okazaki, Y. ; Orlando, V. ; Pang, K. C. ; Pavan, W. J. ; Pavesi, G. ; Pesole, G. ; Petrovsky, N. ; Piazza, S. ; Reed, J. ; Reid, J. F. ; Ring, B. Z. ; Ringwald, M. ; Rost, B. ; Ruan, Y. ; Salzberg, S. L. ; Sandelin, A. ; Schneider, C. ; Schönbach, C. ; Sekiguchi, K. ; Semple, C. A M ; Seno, S. ; Sessa, L. ; Sheng, Y. ; Shibata, Y. ; Shimada, H. ; Shimada, K. ; Silva, D. ; Sinclair, B. ; Sperling, S. ; Stupka, E. ; Sugiura, K. ; Sultana, R. ; Takenaka, Y. ; Taki, K. ; Tammoja, K. ; Tan, S. L. ; Tang, S. ; Taylor, M. S. ; Tegner, J. ; Teichmann, S. A. ; Ueda, H. R. ; van Nimwegene, E. ; Verardo, R. ; Wei, C. L. ; Yagi, K. ; Yamanishi, H. ; Zabarovsky, E. ; Zhu, S. ; Zimmer, A. ; Hide, W. ; Bult, C. ; Grimmond, S. M. ; Teasdale, R. D. ; Liu, E. T. ; Brusic, V. ; Quackenbush, J. ; Wahlestedt, C. ; Mattick, J. S. ; Hume, D. A. ; Kai, C. ; Sasaki, D. ; Tomaru, Y. ; Fukuda, S. ; Kanamori-Katayama, M. ; Suzuki, M. ; Aoki, J. ; Arakawa, T. ; Iida, J. ; Imamura, K. ; Itoh, M. ; Kato, T. ; Kawaji, H. ; Kawagashira, N. ; Kawashima, T. ; Kojima, M. ; Kondo, S. ; Konno, H. ; Nakano, K. ; Ninomiya, N. ; Nishio, T. ; Okada, M. ; Plessy, C. ; Shibata, K. ; Shiraki, T. ; Suzuki, S. ; Tagami, M. ; Waki, K. ; Watahiki, A. ; Okamura-Oho, Y. ; Suzuki, H. ; Kawai, J. ; Hayashizaki, Y. / The transcriptional landscape of the mammalian genome. In: Science. 2005 ; Vol. 309, No. 5740. pp. 1559-1563.
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title = "The transcriptional landscape of the mammalian genome.",
abstract = "This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.",
author = "P. Carninci and T. Kasukawa and S. Katayama and J. Gough and Frith, {M. C.} and N. Maeda and R. Oyama and T. Ravasi and B. Lenhard and C. Wells and R. Kodzius and K. Shimokawa and Bajic, {V. B.} and Brenner, {S. E.} and S. Batalov and Forrest, {A. R R} and M. Zavolan and Davis, {M. J.} and Wilming, {L. G.} and V. Aidinis and Allen, {J. E.} and A. Ambesi-Impiombato and R. Apweiler and Aturaliya, {R. N.} and Bailey, {T. L.} and M. Bansal and L. Baxter and Kirk Beisel and T. Bersano and H. Bono and Chalk, {A. M.} and Chiu, {K. P.} and V. Choudhary and A. Christoffels and Clutterbuck, {D. R.} and Crowe, {M. L.} and E. Dalla and Dalrymple, {B. P.} and {de Bono}, B. and {della Gatta}, G. and {di Bernardo}, D. and T. Down and P. Engstrom and M. Fagiolini and G. Faulkner and Fletcher, {C. F.} and T. Fukushima and M. Furuno and S. Futaki and M. Gariboldi and P. Georgii-Hemming and Gingeras, {T. R.} and T. Gojobori and Green, {R. E.} and S. Gustincich and M. Harbers and Y. Hayashi and Hensch, {T. K.} and N. Hirokawa and D. Hill and L. Huminiecki and M. Iacono and K. Ikeo and A. Iwama and T. Ishikawa and M. Jakt and A. Kanapin and M. Katoh and Y. Kawasawa and J. Kelso and H. Kitamura and H. Kitano and G. Kollias and Krishnan, {S. P T} and Kruger, {A. F.} and Kummerfeld, {S. K.} and Kurochkin, {I. V.} and Lareau, {L. F.} and D. Lazarevic and L. Lipovich and J. Liu and S. Liuni and S. McWilliam and {Madan Babu}, M. and M. Madera and L. Marchionni and H. Matsuda and S. Matsuzawa and H. Miki and F. Mignone and S. Miyake and K. Morris and S. Mottagui-Tabar and N. Mulder and N. Nakano and H. Nakauchi and P. Ng and R. Nilsson and S. Nishiguchi and S. Nishikawa and F. Nori and O. Ohara and Y. Okazaki and V. Orlando and Pang, {K. C.} and Pavan, {W. J.} and G. Pavesi and G. Pesole and N. Petrovsky and S. Piazza and J. Reed and Reid, {J. F.} and Ring, {B. Z.} and M. Ringwald and B. Rost and Y. Ruan and Salzberg, {S. L.} and A. Sandelin and C. Schneider and C. Sch{\"o}nbach and K. Sekiguchi and Semple, {C. A M} and S. Seno and L. Sessa and Y. Sheng and Y. Shibata and H. Shimada and K. Shimada and D. Silva and B. Sinclair and S. Sperling and E. Stupka and K. Sugiura and R. Sultana and Y. Takenaka and K. Taki and K. Tammoja and Tan, {S. L.} and S. Tang and Taylor, {M. S.} and J. Tegner and Teichmann, {S. A.} and Ueda, {H. R.} and {van Nimwegene}, E. and R. Verardo and Wei, {C. L.} and K. Yagi and H. Yamanishi and E. Zabarovsky and S. Zhu and A. Zimmer and W. Hide and C. Bult and Grimmond, {S. M.} and Teasdale, {R. D.} and Liu, {E. T.} and V. Brusic and J. Quackenbush and C. Wahlestedt and Mattick, {J. S.} and Hume, {D. A.} and C. Kai and D. Sasaki and Y. Tomaru and S. Fukuda and M. Kanamori-Katayama and M. Suzuki and J. Aoki and T. Arakawa and J. Iida and K. Imamura and M. Itoh and T. Kato and H. Kawaji and N. Kawagashira and T. Kawashima and M. Kojima and S. Kondo and H. Konno and K. Nakano and N. Ninomiya and T. Nishio and M. Okada and C. Plessy and K. Shibata and T. Shiraki and S. Suzuki and M. Tagami and K. Waki and A. Watahiki and Y. Okamura-Oho and H. Suzuki and J. Kawai and Y. Hayashizaki",
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TY - JOUR

T1 - The transcriptional landscape of the mammalian genome.

AU - Carninci, P.

AU - Kasukawa, T.

AU - Katayama, S.

AU - Gough, J.

AU - Frith, M. C.

AU - Maeda, N.

AU - Oyama, R.

AU - Ravasi, T.

AU - Lenhard, B.

AU - Wells, C.

AU - Kodzius, R.

AU - Shimokawa, K.

AU - Bajic, V. B.

AU - Brenner, S. E.

AU - Batalov, S.

AU - Forrest, A. R R

AU - Zavolan, M.

AU - Davis, M. J.

AU - Wilming, L. G.

AU - Aidinis, V.

AU - Allen, J. E.

AU - Ambesi-Impiombato, A.

AU - Apweiler, R.

AU - Aturaliya, R. N.

AU - Bailey, T. L.

AU - Bansal, M.

AU - Baxter, L.

AU - Beisel, Kirk

AU - Bersano, T.

AU - Bono, H.

AU - Chalk, A. M.

AU - Chiu, K. P.

AU - Choudhary, V.

AU - Christoffels, A.

AU - Clutterbuck, D. R.

AU - Crowe, M. L.

AU - Dalla, E.

AU - Dalrymple, B. P.

AU - de Bono, B.

AU - della Gatta, G.

AU - di Bernardo, D.

AU - Down, T.

AU - Engstrom, P.

AU - Fagiolini, M.

AU - Faulkner, G.

AU - Fletcher, C. F.

AU - Fukushima, T.

AU - Furuno, M.

AU - Futaki, S.

AU - Gariboldi, M.

AU - Georgii-Hemming, P.

AU - Gingeras, T. R.

AU - Gojobori, T.

AU - Green, R. E.

AU - Gustincich, S.

AU - Harbers, M.

AU - Hayashi, Y.

AU - Hensch, T. K.

AU - Hirokawa, N.

AU - Hill, D.

AU - Huminiecki, L.

AU - Iacono, M.

AU - Ikeo, K.

AU - Iwama, A.

AU - Ishikawa, T.

AU - Jakt, M.

AU - Kanapin, A.

AU - Katoh, M.

AU - Kawasawa, Y.

AU - Kelso, J.

AU - Kitamura, H.

AU - Kitano, H.

AU - Kollias, G.

AU - Krishnan, S. P T

AU - Kruger, A. F.

AU - Kummerfeld, S. K.

AU - Kurochkin, I. V.

AU - Lareau, L. F.

AU - Lazarevic, D.

AU - Lipovich, L.

AU - Liu, J.

AU - Liuni, S.

AU - McWilliam, S.

AU - Madan Babu, M.

AU - Madera, M.

AU - Marchionni, L.

AU - Matsuda, H.

AU - Matsuzawa, S.

AU - Miki, H.

AU - Mignone, F.

AU - Miyake, S.

AU - Morris, K.

AU - Mottagui-Tabar, S.

AU - Mulder, N.

AU - Nakano, N.

AU - Nakauchi, H.

AU - Ng, P.

AU - Nilsson, R.

AU - Nishiguchi, S.

AU - Nishikawa, S.

AU - Nori, F.

AU - Ohara, O.

AU - Okazaki, Y.

AU - Orlando, V.

AU - Pang, K. C.

AU - Pavan, W. J.

AU - Pavesi, G.

AU - Pesole, G.

AU - Petrovsky, N.

AU - Piazza, S.

AU - Reed, J.

AU - Reid, J. F.

AU - Ring, B. Z.

AU - Ringwald, M.

AU - Rost, B.

AU - Ruan, Y.

AU - Salzberg, S. L.

AU - Sandelin, A.

AU - Schneider, C.

AU - Schönbach, C.

AU - Sekiguchi, K.

AU - Semple, C. A M

AU - Seno, S.

AU - Sessa, L.

AU - Sheng, Y.

AU - Shibata, Y.

AU - Shimada, H.

AU - Shimada, K.

AU - Silva, D.

AU - Sinclair, B.

AU - Sperling, S.

AU - Stupka, E.

AU - Sugiura, K.

AU - Sultana, R.

AU - Takenaka, Y.

AU - Taki, K.

AU - Tammoja, K.

AU - Tan, S. L.

AU - Tang, S.

AU - Taylor, M. S.

AU - Tegner, J.

AU - Teichmann, S. A.

AU - Ueda, H. R.

AU - van Nimwegene, E.

AU - Verardo, R.

AU - Wei, C. L.

AU - Yagi, K.

AU - Yamanishi, H.

AU - Zabarovsky, E.

AU - Zhu, S.

AU - Zimmer, A.

AU - Hide, W.

AU - Bult, C.

AU - Grimmond, S. M.

AU - Teasdale, R. D.

AU - Liu, E. T.

AU - Brusic, V.

AU - Quackenbush, J.

AU - Wahlestedt, C.

AU - Mattick, J. S.

AU - Hume, D. A.

AU - Kai, C.

AU - Sasaki, D.

AU - Tomaru, Y.

AU - Fukuda, S.

AU - Kanamori-Katayama, M.

AU - Suzuki, M.

AU - Aoki, J.

AU - Arakawa, T.

AU - Iida, J.

AU - Imamura, K.

AU - Itoh, M.

AU - Kato, T.

AU - Kawaji, H.

AU - Kawagashira, N.

AU - Kawashima, T.

AU - Kojima, M.

AU - Kondo, S.

AU - Konno, H.

AU - Nakano, K.

AU - Ninomiya, N.

AU - Nishio, T.

AU - Okada, M.

AU - Plessy, C.

AU - Shibata, K.

AU - Shiraki, T.

AU - Suzuki, S.

AU - Tagami, M.

AU - Waki, K.

AU - Watahiki, A.

AU - Okamura-Oho, Y.

AU - Suzuki, H.

AU - Kawai, J.

AU - Hayashizaki, Y.

PY - 2005/9/2

Y1 - 2005/9/2

N2 - This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

AB - This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

UR - http://www.scopus.com/inward/record.url?scp=24644519490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24644519490&partnerID=8YFLogxK

M3 - Article

C2 - 16141072

AN - SCOPUS:24644519490

VL - 309

SP - 1559

EP - 1563

JO - Science

JF - Science

SN - 0036-8075

IS - 5740

ER -