Abstract
We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p
| Original language | English |
|---|---|
| Pages (from-to) | 60-63 |
| Number of pages | 4 |
| Journal | Pharmacotherapy |
| Volume | 13 |
| Issue number | 1 |
| State | Published - 1993 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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The use of Δ osmolality to predict serum isopropanol and acetone concentrations. / Monaghan, Michael S.; Ackerman, B. H.; Olsen, K. M.; Farmer, C.; Pappas, A. A.
In: Pharmacotherapy, Vol. 13, No. 1, 1993, p. 60-63.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The use of Δ osmolality to predict serum isopropanol and acetone concentrations
AU - Monaghan, Michael S.
AU - Ackerman, B. H.
AU - Olsen, K. M.
AU - Farmer, C.
AU - Pappas, A. A.
PY - 1993
Y1 - 1993
N2 - We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p
AB - We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p
UR - http://www.scopus.com/inward/record.url?scp=0027477847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027477847&partnerID=8YFLogxK
M3 - Article
C2 - 8437968
AN - SCOPUS:0027477847
VL - 13
SP - 60
EP - 63
JO - Pharmacotherapy
JF - Pharmacotherapy
SN - 0277-0008
IS - 1
ER -