The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations

Michael S. Monaghan; Bruce H. Ackerman; Keith M. Olsen; Charles Farmer; Alexandras A. Pappas

doi:10.1002/j.1875-9114.1993.tb02690.x

The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations

Michael S. Monaghan, Bruce H. Ackerman, Keith M. Olsen, Charles Farmer, Alexandras A. Pappas

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p

Original language	English (US)
Pages (from-to)	60-63
Number of pages	4
Journal	Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/j.1875-9114.1993.tb02690.x
State	Published - Jan 1 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology (medical)

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10.1002/j.1875-9114.1993.tb02690.x

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abstract = "We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p",

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AU - Ackerman, Bruce H.

AU - Olsen, Keith M.

AU - Farmer, Charles

AU - Pappas, Alexandras A.

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