The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations

Michael S. Monaghan, Bruce H. Ackerman, Keith M. Olsen, Charles Farmer, Alexandras A. Pappas

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p

Original languageEnglish (US)
Pages (from-to)60-63
Number of pages4
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)


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