Abstract
We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p
Original language | English (US) |
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Pages (from-to) | 60-63 |
Number of pages | 4 |
Journal | Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1993 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)