The use of Δ osmolality to predict serum isopropanol and acetone concentrations

Michael S. Monaghan, B. H. Ackerman, K. M. Olsen, C. Farmer, A. A. Pappas

Research output: Contribution to journalArticle

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Abstract

We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalPharmacotherapy
Volume13
Issue number1
StatePublished - 1993
Externally publishedYes

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2-Propanol
Acetone
Osmolar Concentration
Serum
Osmometry
Gas Chromatography
Freezing
Linear Models
Eating
Head

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Monaghan, M. S., Ackerman, B. H., Olsen, K. M., Farmer, C., & Pappas, A. A. (1993). The use of Δ osmolality to predict serum isopropanol and acetone concentrations. Pharmacotherapy, 13(1), 60-63.

The use of Δ osmolality to predict serum isopropanol and acetone concentrations. / Monaghan, Michael S.; Ackerman, B. H.; Olsen, K. M.; Farmer, C.; Pappas, A. A.

In: Pharmacotherapy, Vol. 13, No. 1, 1993, p. 60-63.

Research output: Contribution to journalArticle

Monaghan, MS, Ackerman, BH, Olsen, KM, Farmer, C & Pappas, AA 1993, 'The use of Δ osmolality to predict serum isopropanol and acetone concentrations', Pharmacotherapy, vol. 13, no. 1, pp. 60-63.
Monaghan, Michael S. ; Ackerman, B. H. ; Olsen, K. M. ; Farmer, C. ; Pappas, A. A. / The use of Δ osmolality to predict serum isopropanol and acetone concentrations. In: Pharmacotherapy. 1993 ; Vol. 13, No. 1. pp. 60-63.
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