The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations

Michael S. Monaghan; Bruce H. Ackerman; Keith M. Olsen; Charles Farmer; Alexandras A. Pappas

doi:10.1002/j.1875-9114.1993.tb02690.x

The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations

Michael S. Monaghan, Bruce H. Ackerman, Keith M. Olsen, Charles Farmer, Alexandras A. Pappas

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p

Original language	English (US)
Pages (from-to)	60-63
Number of pages	4
Journal	Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/j.1875-9114.1993.tb02690.x
State	Published - Jan 1 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology (medical)

Access to Document

10.1002/j.1875-9114.1993.tb02690.x

Fingerprint Dive into the research topics of 'The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations'. Together they form a unique fingerprint.

Cite this

@article{dc5364ed137749e9a1657a84ed3f04dc,

title = "The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations",

abstract = "We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p",

author = "Monaghan, {Michael S.} and Ackerman, {Bruce H.} and Olsen, {Keith M.} and Charles Farmer and Pappas, {Alexandras A.}",

year = "1993",

month = jan,

day = "1",

doi = "10.1002/j.1875-9114.1993.tb02690.x",

language = "English (US)",

volume = "13",

pages = "60--63",

journal = "Pharmacotherapy",

issn = "0277-0008",

publisher = "Pharmacotherapy Publications Inc.",

number = "1",

}

TY - JOUR

T1 - The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations

AU - Monaghan, Michael S.

AU - Ackerman, Bruce H.

AU - Olsen, Keith M.

AU - Farmer, Charles

AU - Pappas, Alexandras A.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p

AB - We investigated whether serum Δ osmolality will predict the total serum concentration of isopropanol and acetone metabolite. Three isopropanol ingestions were monitored by Δ osmolality determinations followed by quantification of serum isopropanol and acetone concentrations. The Δ osmolality was established by routine chemical analysis and standard freezing point depression osmometry. Serum isopropanol and acetone levels were quantified by gas chromatography-head space analysis (GC-HS). Patients were initially suspected of having isopropanol intoxication secondary to an elevated Δ osmolality discrepancy (measured - calculated > 10 mOsm). Serum concentrations versus Δ osmolality were analyzed by linear regression (correlation coefficient r=0.713; p

UR - http://www.scopus.com/inward/record.url?scp=0027477847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027477847&partnerID=8YFLogxK

U2 - 10.1002/j.1875-9114.1993.tb02690.x

DO - 10.1002/j.1875-9114.1993.tb02690.x

M3 - Article

C2 - 8437968

AN - SCOPUS:0027477847

VL - 13

SP - 60

EP - 63

JO - Pharmacotherapy

JF - Pharmacotherapy

SN - 0277-0008

IS - 1

ER -

The Use of Δ Osmolality to Predict Serum Isopropanol and Acetone Concentrations

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Cite this