Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line

Medicine & Life Sciences

• Amitriptyline 76%
• Neuropeptide Y 70%
• Valproic Acid 66%
• Neuroblastoma 60%
• Cell Line 36%
• Tetradecanoylphorbol Acetate 15%
• Therapeutics 10%
• Anticonvulsants 8%
• Seizures 7%
• Anxiety 6%
• Obesity 6%
• Depression 6%
• Peptides 5%
• thiazolyl blue 5%
• Polymerase Chain Reaction 5%
• Messenger RNA 5%
• Autonomic Nervous System 5%
• Circadian Rhythm 4%
• Protein Kinase C 4%
• Weight Gain 4%
• Antidepressive Agents 4%
• Fluorescent Antibody Technique 4%
• Epilepsy 3%
• Sleep 3%
• Cell Survival 3%
• Learning 3%
• Memory 3%
• Up-Regulation 3%
• Immunohistochemistry 3%
• Phenotype 2%
• Brain 2%
• Pharmaceutical Preparations 1%
• Neoplasms 1%

Chemical Compounds

• Valproate 100%
• Neuropeptide Y 91%
• Amitriptyline 86%
• Anticonvulsant 10%
• Antidepressant Agent 6%
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide 6%
• Weight Gain 5%
• Plasma Concentration 5%
• Peptide 5%
• Drug 4%
• Cell Viability 4%
• Protein 1%