Abstract
Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells. Such vaccine treatment strategies may provide benefit for Parkinson's disease.
| Original language | English |
|---|---|
| Pages (from-to) | 9435-9440 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 101 |
| Issue number | 25 |
| DOIs | |
| State | Published - Jun 22 2004 |
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All Science Journal Classification (ASJC) codes
- Genetics
- General
Cite this
Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. / Benner, Eric J.; Mosley, R. Lee; Destache, Christopher J.; Lewis, Travis B.; Jackson-Lewis, Vernice; Gorantla, Santhi; Nemachek, Craig; Green, Steven R.; Przedborski, Serge; Gendelman, Howard E.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 25, 22.06.2004, p. 9435-9440.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
AU - Benner, Eric J.
AU - Mosley, R. Lee
AU - Destache, Christopher J.
AU - Lewis, Travis B.
AU - Jackson-Lewis, Vernice
AU - Gorantla, Santhi
AU - Nemachek, Craig
AU - Green, Steven R.
AU - Przedborski, Serge
AU - Gendelman, Howard E.
PY - 2004/6/22
Y1 - 2004/6/22
N2 - Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells. Such vaccine treatment strategies may provide benefit for Parkinson's disease.
AB - Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells. Such vaccine treatment strategies may provide benefit for Parkinson's disease.
UR - http://www.scopus.com/inward/record.url?scp=3042592589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042592589&partnerID=8YFLogxK
U2 - 10.1073/pnas.0400569101
DO - 10.1073/pnas.0400569101
M3 - Article
C2 - 15197276
AN - SCOPUS:3042592589
VL - 101
SP - 9435
EP - 9440
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 25
ER -