Therapeutic potential of exosomes in rotator cuff tendon healing

Denton E. Connor, Jordan A. Paulus, Parinaz Jila Dabestani, Finosh K. Thankam, Matthew Dilisio, R. Michael Gross, Devendra K. Agrawal

Research output: Contribution to journalReview article

Abstract

Rotator cuff tears are common musculoskeletal injuries that can cause significant pain and disability. While the clinical results of rotator cuff repair can be good, failure of tendon healing remains a significant problem. Molecular mechanisms underlying structural failure following surgical repair remain unclear. Histologically, enhanced inflammation, disorganization of the collagen fibers, calcification, apoptosis and tissue necrosis affect the normal healing process. Mesenchymal stem cells (MSCs) have the ability to provide improved healing following rotator cuff repair via the release of mediators from secreted 30–100 nm extracellular vesicles called exosomes. They carry regulatory proteins, mRNA and miRNA and have the ability to increase collagen synthesis and angiogenesis through increased expression of mRNA and release of proangiogenic factors and regulatory proteins that play a major role in proper tissue remodeling and preventing extracellular matrix degradation. Various studies have shown the effect of exosomes on improving outcome of cutaneous wound healing, scar tissue formation, degenerative bone disease and Duchenne Muscular Dystrophy. In this article, we critically reviewed the potential role of exosomes in tendon regeneration and propose the novel use of exosomes alone or seeded onto biomaterial matrices to stimulate secretion of favorable cellular factors in accelerating the healing response following rotator cuff repair.

Original languageEnglish (US)
JournalJournal of Bone and Mineral Metabolism
DOIs
StatePublished - Jan 1 2019

Fingerprint

Exosomes
Rotator Cuff
Tendons
Aptitude
Collagen
Messenger RNA
Duchenne Muscular Dystrophy
Bone Diseases
Biocompatible Materials
Therapeutics
MicroRNAs
Mesenchymal Stromal Cells
Wound Healing
Cicatrix
Extracellular Matrix
Regeneration
Proteins
Necrosis
Apoptosis
Inflammation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Therapeutic potential of exosomes in rotator cuff tendon healing. / Connor, Denton E.; Paulus, Jordan A.; Dabestani, Parinaz Jila; Thankam, Finosh K.; Dilisio, Matthew; Gross, R. Michael; Agrawal, Devendra K.

In: Journal of Bone and Mineral Metabolism, 01.01.2019.

Research output: Contribution to journalReview article

Connor, Denton E. ; Paulus, Jordan A. ; Dabestani, Parinaz Jila ; Thankam, Finosh K. ; Dilisio, Matthew ; Gross, R. Michael ; Agrawal, Devendra K. / Therapeutic potential of exosomes in rotator cuff tendon healing. In: Journal of Bone and Mineral Metabolism. 2019.
@article{967a4de76a034b43b50210ce4c17619c,
title = "Therapeutic potential of exosomes in rotator cuff tendon healing",
abstract = "Rotator cuff tears are common musculoskeletal injuries that can cause significant pain and disability. While the clinical results of rotator cuff repair can be good, failure of tendon healing remains a significant problem. Molecular mechanisms underlying structural failure following surgical repair remain unclear. Histologically, enhanced inflammation, disorganization of the collagen fibers, calcification, apoptosis and tissue necrosis affect the normal healing process. Mesenchymal stem cells (MSCs) have the ability to provide improved healing following rotator cuff repair via the release of mediators from secreted 30–100 nm extracellular vesicles called exosomes. They carry regulatory proteins, mRNA and miRNA and have the ability to increase collagen synthesis and angiogenesis through increased expression of mRNA and release of proangiogenic factors and regulatory proteins that play a major role in proper tissue remodeling and preventing extracellular matrix degradation. Various studies have shown the effect of exosomes on improving outcome of cutaneous wound healing, scar tissue formation, degenerative bone disease and Duchenne Muscular Dystrophy. In this article, we critically reviewed the potential role of exosomes in tendon regeneration and propose the novel use of exosomes alone or seeded onto biomaterial matrices to stimulate secretion of favorable cellular factors in accelerating the healing response following rotator cuff repair.",
author = "Connor, {Denton E.} and Paulus, {Jordan A.} and Dabestani, {Parinaz Jila} and Thankam, {Finosh K.} and Matthew Dilisio and Gross, {R. Michael} and Agrawal, {Devendra K.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00774-019-01013-z",
language = "English (US)",
journal = "Journal of Bone and Mineral Metabolism",
issn = "0914-8779",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Therapeutic potential of exosomes in rotator cuff tendon healing

AU - Connor, Denton E.

AU - Paulus, Jordan A.

AU - Dabestani, Parinaz Jila

AU - Thankam, Finosh K.

AU - Dilisio, Matthew

AU - Gross, R. Michael

AU - Agrawal, Devendra K.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Rotator cuff tears are common musculoskeletal injuries that can cause significant pain and disability. While the clinical results of rotator cuff repair can be good, failure of tendon healing remains a significant problem. Molecular mechanisms underlying structural failure following surgical repair remain unclear. Histologically, enhanced inflammation, disorganization of the collagen fibers, calcification, apoptosis and tissue necrosis affect the normal healing process. Mesenchymal stem cells (MSCs) have the ability to provide improved healing following rotator cuff repair via the release of mediators from secreted 30–100 nm extracellular vesicles called exosomes. They carry regulatory proteins, mRNA and miRNA and have the ability to increase collagen synthesis and angiogenesis through increased expression of mRNA and release of proangiogenic factors and regulatory proteins that play a major role in proper tissue remodeling and preventing extracellular matrix degradation. Various studies have shown the effect of exosomes on improving outcome of cutaneous wound healing, scar tissue formation, degenerative bone disease and Duchenne Muscular Dystrophy. In this article, we critically reviewed the potential role of exosomes in tendon regeneration and propose the novel use of exosomes alone or seeded onto biomaterial matrices to stimulate secretion of favorable cellular factors in accelerating the healing response following rotator cuff repair.

AB - Rotator cuff tears are common musculoskeletal injuries that can cause significant pain and disability. While the clinical results of rotator cuff repair can be good, failure of tendon healing remains a significant problem. Molecular mechanisms underlying structural failure following surgical repair remain unclear. Histologically, enhanced inflammation, disorganization of the collagen fibers, calcification, apoptosis and tissue necrosis affect the normal healing process. Mesenchymal stem cells (MSCs) have the ability to provide improved healing following rotator cuff repair via the release of mediators from secreted 30–100 nm extracellular vesicles called exosomes. They carry regulatory proteins, mRNA and miRNA and have the ability to increase collagen synthesis and angiogenesis through increased expression of mRNA and release of proangiogenic factors and regulatory proteins that play a major role in proper tissue remodeling and preventing extracellular matrix degradation. Various studies have shown the effect of exosomes on improving outcome of cutaneous wound healing, scar tissue formation, degenerative bone disease and Duchenne Muscular Dystrophy. In this article, we critically reviewed the potential role of exosomes in tendon regeneration and propose the novel use of exosomes alone or seeded onto biomaterial matrices to stimulate secretion of favorable cellular factors in accelerating the healing response following rotator cuff repair.

UR - http://www.scopus.com/inward/record.url?scp=85066471076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066471076&partnerID=8YFLogxK

U2 - 10.1007/s00774-019-01013-z

DO - 10.1007/s00774-019-01013-z

M3 - Review article

JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

SN - 0914-8779

ER -