Therapeutic ultrasound-enhanced thrombolysis in patients with acute myocardial infarction

Xuedong Shen, Chandra Nair, Mark Jeffrey Holmberg, Aryan N. Mooss, Amy Arouni, Dennis J. Esterbrooks

Research output: Contribution to journalReview article

2 Scopus citations


Thrombolytic therapy is widely used to treat the patients with ST elevation acute myocardial infarction (STE-MI). Due to logistic and economic reasons, only 10% of patients with acute myocardial infarction can be treated with the percutaneous coronary intervention (PCI). Optimal flow (TIMI (Thrombolysis In Myocardial Infarction) 3 flow) is achieved in only about 60% of cases by enzymatic thrombolysis. Therapeutic ultrasound (US) exerts an effect on thrombolysis by micromechanical processes or indirectly by supporting enzymatic thrombolysis. This review examines relevant experimental and clinical published data. Technical issues in therapeutic US-enhanced thrombolysis in patients with acute myocardial infarction and advancements of the techniques during recent 10 years are discussed.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
Issue number3
StatePublished - Jun 2010


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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