Thymic epithelial neoplasms in transgenic mice expressing SV40 T antigen under the control of an erythroid‐specific enhancer

Tal Teitz, Judy C. Chang, Yuet Wai Kan, T. S.Benedict Yen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The β‐globin locus control region is known to be a powerful erythroid‐specific enhancer. In an attempt to produce immortalized erythroid percursor cells, transgenic mice have been generated with the simian virus (SV) 40 T antigen gene under the control of the locus control region. As previously reported, transgenic mice did not develop erythroleukaemia, but rather succumbed to insulinomas and poorly differentiated rhabdomyosarcomas. This paper describes additional mice containing this transgene that developed thymomas of the mixed epithelial/lymphocytic type, in which only the epithelial component expressed the T antigen. Epithelial cell lines have been established from these tumours. This system may be useful in future studies on the pathogenesis of thymomas and the function of thymic epithelial cells.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalInvestigative and Cell Pathology
Volume177
Issue number3
DOIs
StatePublished - Nov 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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