Tn4201, a β-lactamase transposon in Staphylococcus aureus

D. A. Weber, R. V. Goering

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Abstract

We report the preliminary characterization of a 6.7-kilobase transposon, Tn4201, encoding resistance to penicillin associated with the conjugative plasmid pCRG1600 in Staphylococcus aureus. Tn4201 is capable of inverting in orientation (frequently observed in derivatives of pCRG1600) and is expressed equally well in either orientation. The element is also capable of movement to alternative plasmid and chromosomal sites. Tn4201 exhibits rec-independent transposition in an apparent site-specific manner and may play an important role in the resistance of staphylococci to β-lactam compounds.

Original languageEnglish (US)
Pages (from-to)1164-1169
Number of pages6
JournalAntimicrobial agents and chemotherapy
Volume32
Issue number8
DOIs
StatePublished - Jan 1 1988

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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