Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome)

Patrice Watson, Ramesh Ashwathnarayan, Henry T. Lynch, Hemant K. Roy

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Background: The marked variability in age at onset of colorectal cancer (CRC) in patients with hereditary non-polyposis colorectal cancer (HNPCC) makes management decisions difficult. Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated. Methods: We determined whether tobacco use would alter CRC risk in carriers of HNPCC-associated mutations, using a retrospective cohort study of germline mutation (hMLH1 or hMSH2) carriers from the Hereditary Cancer Institute at Creighton University, one of the oldest and largest registries of HNPCC patients. The main outcome measure was age at CRC onset, estimated by means of Cox proportional hazards modeling. Results: Tobacco use, hMLH1 mutation carriage (as opposed to hMSH2), and male sex were significantly associated with increased risk of CRC (hazard ratios, 1.43, 2.07, and 1.58, respectively). Alcohol use did not alter CRC risk. Conclusions: Smoking cessation should be an integral part of HNPCC management. This study underscores the gene × environment interactions in cancer development.

Original languageEnglish
Pages (from-to)2429-2431
Number of pages3
JournalArchives of Internal Medicine
Volume164
Issue number22
DOIs
StatePublished - Dec 13 2004

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Hereditary Nonpolyposis Colorectal Neoplasms
Tobacco Use
Colorectal Neoplasms
Gene-Environment Interaction
Neoplasms
Mutation
Germ-Line Mutation
Smoking Cessation
Age of Onset
Registries
Cohort Studies
Retrospective Studies
Alcohols
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome). / Watson, Patrice; Ashwathnarayan, Ramesh; Lynch, Henry T.; Roy, Hemant K.

In: Archives of Internal Medicine, Vol. 164, No. 22, 13.12.2004, p. 2429-2431.

Research output: Contribution to journalArticle

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N2 - Background: The marked variability in age at onset of colorectal cancer (CRC) in patients with hereditary non-polyposis colorectal cancer (HNPCC) makes management decisions difficult. Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated. Methods: We determined whether tobacco use would alter CRC risk in carriers of HNPCC-associated mutations, using a retrospective cohort study of germline mutation (hMLH1 or hMSH2) carriers from the Hereditary Cancer Institute at Creighton University, one of the oldest and largest registries of HNPCC patients. The main outcome measure was age at CRC onset, estimated by means of Cox proportional hazards modeling. Results: Tobacco use, hMLH1 mutation carriage (as opposed to hMSH2), and male sex were significantly associated with increased risk of CRC (hazard ratios, 1.43, 2.07, and 1.58, respectively). Alcohol use did not alter CRC risk. Conclusions: Smoking cessation should be an integral part of HNPCC management. This study underscores the gene × environment interactions in cancer development.

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