Trabecular bone microarchitecture after alendronate treatment of osteoporotic women

Robert R. Recker, P. Masarachia, A. Santora, T. Howard, P. Chavassieux, M. Arlot, G. Rodan, L. Wehren, D. Kimmel

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Abstract

Objective: To compare the microarchitecture of iliac crest trabecular bone from women treated for two to three years with alendronate versus that of women treated with placebo. Research design and methods. Three-dimensional microcomputed tomography (micro-CT; resolution 20 μm) and two-dimensional histomorphometry (resolution 5-7 μm) were used to examine trabecular bone from single transilial biopsies obtained at the completion of clinical trials. Main outcome measures: Microarchitectural variables, including bone volume, trabecular number, trabecular thickness, and trabecular spacing in specimens from alendronate- and placebo-treated women were examined. Three-dimensional images of trabecular bone from both groups were constructed from CT images. Correlations among variables and between techniques were also calculated. Results: Eighty-eight specimens were suitable for evaluation by both techniques. As measured by two-dimensional histomorphometry, bone volume fraction (as a proportion of total volume) and trabecular thickness were significantly greater in alendronate specimens, 17.1 ± 5.5% vs. 13.4 ± 5.5% (p = 0.0043) and 127 ± 29 μm vs. 109 ± 28 μm (p = 0.0090), respectively, and trabecular spacing was significantly smaller, 729 ± 227 μm vs. 862 ± 338 μm (p = 0.005). Micro-CT yielded similar findings: bone volume and trabecular number were significantly greater in alendronate specimens: 19.4 ± 6.2% vs. 16.2 ± 6.3% (p = 0.0412) and 1.46 ± 0.32 vs. 1.31 ± 0.33 per mm (p = 0.0346). Two-dimensional and micro-CT measured characteristics correlated strongly with one another, with Pearson product moment correlation coefficients ranging from 0.60 (for trabecular thickness) to 0.83 (for bone volume). Conclusions: Trabecular microarchitecture of the ilium, whether studied by two- or three-dimensional methods, is better (greater bone volume, greater trabecular thickness, decreased trabecular spacing) after alendronate treatment than after two to three years of treatment with placebo. Bone volume in a trabecular region is strongly correlated to its microarchitecture, suggesting that bone quantity predicts values for these microarchitectural endpoints.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalCurrent Medical Research and Opinion
Volume21
Issue number2
DOIs
StatePublished - Feb 2005

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Alendronate
Bone and Bones
Placebos
Ilium
Therapeutics
X-Ray Microtomography
Three-Dimensional Imaging
Research Design
Outcome Assessment (Health Care)
Cancellous Bone
Clinical Trials
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Recker, R. R., Masarachia, P., Santora, A., Howard, T., Chavassieux, P., Arlot, M., ... Kimmel, D. (2005). Trabecular bone microarchitecture after alendronate treatment of osteoporotic women. Current Medical Research and Opinion, 21(2), 185-194. https://doi.org/10.1185/030079904X20259

Trabecular bone microarchitecture after alendronate treatment of osteoporotic women. / Recker, Robert R.; Masarachia, P.; Santora, A.; Howard, T.; Chavassieux, P.; Arlot, M.; Rodan, G.; Wehren, L.; Kimmel, D.

In: Current Medical Research and Opinion, Vol. 21, No. 2, 02.2005, p. 185-194.

Research output: Contribution to journalArticle

Recker, RR, Masarachia, P, Santora, A, Howard, T, Chavassieux, P, Arlot, M, Rodan, G, Wehren, L & Kimmel, D 2005, 'Trabecular bone microarchitecture after alendronate treatment of osteoporotic women', Current Medical Research and Opinion, vol. 21, no. 2, pp. 185-194. https://doi.org/10.1185/030079904X20259
Recker, Robert R. ; Masarachia, P. ; Santora, A. ; Howard, T. ; Chavassieux, P. ; Arlot, M. ; Rodan, G. ; Wehren, L. ; Kimmel, D. / Trabecular bone microarchitecture after alendronate treatment of osteoporotic women. In: Current Medical Research and Opinion. 2005 ; Vol. 21, No. 2. pp. 185-194.
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abstract = "Objective: To compare the microarchitecture of iliac crest trabecular bone from women treated for two to three years with alendronate versus that of women treated with placebo. Research design and methods. Three-dimensional microcomputed tomography (micro-CT; resolution 20 μm) and two-dimensional histomorphometry (resolution 5-7 μm) were used to examine trabecular bone from single transilial biopsies obtained at the completion of clinical trials. Main outcome measures: Microarchitectural variables, including bone volume, trabecular number, trabecular thickness, and trabecular spacing in specimens from alendronate- and placebo-treated women were examined. Three-dimensional images of trabecular bone from both groups were constructed from CT images. Correlations among variables and between techniques were also calculated. Results: Eighty-eight specimens were suitable for evaluation by both techniques. As measured by two-dimensional histomorphometry, bone volume fraction (as a proportion of total volume) and trabecular thickness were significantly greater in alendronate specimens, 17.1 ± 5.5{\%} vs. 13.4 ± 5.5{\%} (p = 0.0043) and 127 ± 29 μm vs. 109 ± 28 μm (p = 0.0090), respectively, and trabecular spacing was significantly smaller, 729 ± 227 μm vs. 862 ± 338 μm (p = 0.005). Micro-CT yielded similar findings: bone volume and trabecular number were significantly greater in alendronate specimens: 19.4 ± 6.2{\%} vs. 16.2 ± 6.3{\%} (p = 0.0412) and 1.46 ± 0.32 vs. 1.31 ± 0.33 per mm (p = 0.0346). Two-dimensional and micro-CT measured characteristics correlated strongly with one another, with Pearson product moment correlation coefficients ranging from 0.60 (for trabecular thickness) to 0.83 (for bone volume). Conclusions: Trabecular microarchitecture of the ilium, whether studied by two- or three-dimensional methods, is better (greater bone volume, greater trabecular thickness, decreased trabecular spacing) after alendronate treatment than after two to three years of treatment with placebo. Bone volume in a trabecular region is strongly correlated to its microarchitecture, suggesting that bone quantity predicts values for these microarchitectural endpoints.",
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AU - Masarachia, P.

AU - Santora, A.

AU - Howard, T.

AU - Chavassieux, P.

AU - Arlot, M.

AU - Rodan, G.

AU - Wehren, L.

AU - Kimmel, D.

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N2 - Objective: To compare the microarchitecture of iliac crest trabecular bone from women treated for two to three years with alendronate versus that of women treated with placebo. Research design and methods. Three-dimensional microcomputed tomography (micro-CT; resolution 20 μm) and two-dimensional histomorphometry (resolution 5-7 μm) were used to examine trabecular bone from single transilial biopsies obtained at the completion of clinical trials. Main outcome measures: Microarchitectural variables, including bone volume, trabecular number, trabecular thickness, and trabecular spacing in specimens from alendronate- and placebo-treated women were examined. Three-dimensional images of trabecular bone from both groups were constructed from CT images. Correlations among variables and between techniques were also calculated. Results: Eighty-eight specimens were suitable for evaluation by both techniques. As measured by two-dimensional histomorphometry, bone volume fraction (as a proportion of total volume) and trabecular thickness were significantly greater in alendronate specimens, 17.1 ± 5.5% vs. 13.4 ± 5.5% (p = 0.0043) and 127 ± 29 μm vs. 109 ± 28 μm (p = 0.0090), respectively, and trabecular spacing was significantly smaller, 729 ± 227 μm vs. 862 ± 338 μm (p = 0.005). Micro-CT yielded similar findings: bone volume and trabecular number were significantly greater in alendronate specimens: 19.4 ± 6.2% vs. 16.2 ± 6.3% (p = 0.0412) and 1.46 ± 0.32 vs. 1.31 ± 0.33 per mm (p = 0.0346). Two-dimensional and micro-CT measured characteristics correlated strongly with one another, with Pearson product moment correlation coefficients ranging from 0.60 (for trabecular thickness) to 0.83 (for bone volume). Conclusions: Trabecular microarchitecture of the ilium, whether studied by two- or three-dimensional methods, is better (greater bone volume, greater trabecular thickness, decreased trabecular spacing) after alendronate treatment than after two to three years of treatment with placebo. Bone volume in a trabecular region is strongly correlated to its microarchitecture, suggesting that bone quantity predicts values for these microarchitectural endpoints.

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