Transcatheter aortic valve replacement in mixed aortic valve disease: A systematic review and meta-analysis

Raviteja R. Guddeti, Gauravpal S. Gill, Hector M. Garcia-Garcia, Venkata Mahesh Alla

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Utilization of transcatheter aortic valve replacement (TAVR) has expanded from high-risk patients to intermediate- A nd select low-risk candidates with severe aortic stenosis (AS). TAVR is currently not indicated for patients with aortic insufficiency, and its outcomes in mixed aortic valve disease (MAVD) are unclear. Methods: A systematic search of PubMed, Medline, CINHAL, and Cochrane databases was performed to identify studies comparing TAVR outcomes in patients with AS vs. MAVD. Primary outcomes included 30-day and late all-cause mortality, and paravalvular regurgitation (PVR). Secondary outcomes were major bleeding, vascular complications, device implantation success, permanent pacemaker, and stroke. Pooled odds ratios (OR) and 95% confidence intervals (CIs) were calculated using Der Simonian-Laird random-effects model. Results: Six observational studies with 58 879 patients were included in the analysis. There was no significant difference in 30-day all-cause mortality [OR 1.03 (95% CI 0.92-1.15); P = 0.63], however, MAVD group had higher odds of moderate-to-severe PVR [1.81 (1.41-2.31); P < 0.01]. MAVD patients had lower odds of device implantation success [0.60 (0.40-0.91); P = 0.02] while other secondary outcomes were similar in the two groups. Conclusions: TAVR in MAVD is associated with increased odds of paravalvular regurgitation and lower odds of device implantation success when compared to severe aortic stenosis.

Original languageEnglish (US)
Pages (from-to)169-176
Number of pages8
JournalEuropean heart journal. Quality of care &amp; clinical outcomes
Issue number2
StatePublished - Mar 1 2022

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Cardiology and Cardiovascular Medicine


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