Transcription factors expressed in mouse cochlear inner and outer hair cells

Yi Li, Huizhan Liu, Cody L. Barta, Paul D. Judge, Lidong Zhao, Weiping J. Zhang, Shusheng Gong, Kirk Beisel, David Z. He

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Regulation of gene expression is essential to determining the functional complexity and morphological diversity seen among different cells. Transcriptional regulation is a crucial step in gene expression regulation because the genetic information is directly read from DNA by sequence-specific transcription factors (TFs). Although several mouse TF databases created from genome sequences and transcriptomes are available, a cell type-specific TF database from any normal cell populations is still lacking. We identify cell type-specific TF genes expressed in cochlear inner hair cells (IHCs) and outer hair cells (OHCs) using hair cell-specific transcriptomes from adult mice. IHCs and OHCs are the two types of sensory receptor cells in the mammalian cochlea. We show that 1,563 and 1,616 TF genes are respectively expressed in IHCs and OHCs among 2,230 putative mouse TF genes. While 1,536 are commonly expressed in both populations, 73 genes are differentially expressed (with at least a twofold difference) in IHCs and 13 are differentially expressed in OHCs. Our datasets represent the first cell type-specific TF databases for two populations of sensory receptor cells and are key informational resources for understanding the molecular mechanism underlying the biological properties and phenotypical differences of these cells.

Original languageEnglish
Article numbere0151291
JournalPLoS One
Volume11
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Outer Auditory Hair Cells
Inner Auditory Hair Cells
hairs
Transcription Factors
transcription factors
Cells
mice
Genes
cells
Gene Expression Regulation
Databases
Sensory Receptor Cells
Transcriptome
Gene expression regulation
Population
Cochlea
sensory receptors
Gene expression
gene expression regulation
transcriptome

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Li, Y., Liu, H., Barta, C. L., Judge, P. D., Zhao, L., Zhang, W. J., ... He, D. Z. (2016). Transcription factors expressed in mouse cochlear inner and outer hair cells. PLoS One, 11(3), [e0151291]. https://doi.org/10.1371/journal.pone.0151291

Transcription factors expressed in mouse cochlear inner and outer hair cells. / Li, Yi; Liu, Huizhan; Barta, Cody L.; Judge, Paul D.; Zhao, Lidong; Zhang, Weiping J.; Gong, Shusheng; Beisel, Kirk; He, David Z.

In: PLoS One, Vol. 11, No. 3, e0151291, 01.03.2016.

Research output: Contribution to journalArticle

Li, Y, Liu, H, Barta, CL, Judge, PD, Zhao, L, Zhang, WJ, Gong, S, Beisel, K & He, DZ 2016, 'Transcription factors expressed in mouse cochlear inner and outer hair cells', PLoS One, vol. 11, no. 3, e0151291. https://doi.org/10.1371/journal.pone.0151291
Li Y, Liu H, Barta CL, Judge PD, Zhao L, Zhang WJ et al. Transcription factors expressed in mouse cochlear inner and outer hair cells. PLoS One. 2016 Mar 1;11(3). e0151291. https://doi.org/10.1371/journal.pone.0151291
Li, Yi ; Liu, Huizhan ; Barta, Cody L. ; Judge, Paul D. ; Zhao, Lidong ; Zhang, Weiping J. ; Gong, Shusheng ; Beisel, Kirk ; He, David Z. / Transcription factors expressed in mouse cochlear inner and outer hair cells. In: PLoS One. 2016 ; Vol. 11, No. 3.
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