Abstract
Dendritic cells (DCs) are potent antigen-presenting cells that guard all parts of the body. They have the unique ability to prime T cells and generate primary immune responses. Their journey beginning with the development from precursor cells and ending with their death is controlled by a group of transcription factors. Some of the transcription factors like PU.1 are involved in more than one stage of DC life. Other transcription factors including Ikaros and JAK3 are involved in the development of more than one cell type. For a long time, the cellular and molecular mechanisms underlying the development, differentiation, maturation, and other stages of DC life were not well understood. However, in recent years novel information has been published by many researchers to better understand the molecular mechanisms of the development and function of DCs in immunological diseases such as asthma, cancer, autoimmunity, and transplantation. This review will discuss the various transcription factors and signaling pathways involved in each stage of the life cycle of DCs.
| Original language | English |
|---|---|
| Pages (from-to) | 79-96 |
| Number of pages | 18 |
| Journal | Immunologic Research |
| Volume | 37 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2007 |
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All Science Journal Classification (ASJC) codes
- Immunology
Cite this
Transcription factors in the control of dendritic cell life cycle. / Bharadwaj, Arpita S.; Agrawal, Devendra K.
In: Immunologic Research, Vol. 37, No. 1, 01.2007, p. 79-96.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Transcription factors in the control of dendritic cell life cycle
AU - Bharadwaj, Arpita S.
AU - Agrawal, Devendra K.
PY - 2007/1
Y1 - 2007/1
N2 - Dendritic cells (DCs) are potent antigen-presenting cells that guard all parts of the body. They have the unique ability to prime T cells and generate primary immune responses. Their journey beginning with the development from precursor cells and ending with their death is controlled by a group of transcription factors. Some of the transcription factors like PU.1 are involved in more than one stage of DC life. Other transcription factors including Ikaros and JAK3 are involved in the development of more than one cell type. For a long time, the cellular and molecular mechanisms underlying the development, differentiation, maturation, and other stages of DC life were not well understood. However, in recent years novel information has been published by many researchers to better understand the molecular mechanisms of the development and function of DCs in immunological diseases such as asthma, cancer, autoimmunity, and transplantation. This review will discuss the various transcription factors and signaling pathways involved in each stage of the life cycle of DCs.
AB - Dendritic cells (DCs) are potent antigen-presenting cells that guard all parts of the body. They have the unique ability to prime T cells and generate primary immune responses. Their journey beginning with the development from precursor cells and ending with their death is controlled by a group of transcription factors. Some of the transcription factors like PU.1 are involved in more than one stage of DC life. Other transcription factors including Ikaros and JAK3 are involved in the development of more than one cell type. For a long time, the cellular and molecular mechanisms underlying the development, differentiation, maturation, and other stages of DC life were not well understood. However, in recent years novel information has been published by many researchers to better understand the molecular mechanisms of the development and function of DCs in immunological diseases such as asthma, cancer, autoimmunity, and transplantation. This review will discuss the various transcription factors and signaling pathways involved in each stage of the life cycle of DCs.
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U2 - 10.1007/s12026-007-0012-4
DO - 10.1007/s12026-007-0012-4
M3 - Review article
VL - 37
SP - 79
EP - 96
JO - Immunologic Research
JF - Immunologic Research
SN - 0257-277X
IS - 1
ER -