Transcription factors in the control of dendritic cell life cycle

Arpita S. Bharadwaj, Devendra K. Agrawal

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Dendritic cells (DCs) are potent antigen-presenting cells that guard all parts of the body. They have the unique ability to prime T cells and generate primary immune responses. Their journey beginning with the development from precursor cells and ending with their death is controlled by a group of transcription factors. Some of the transcription factors like PU.1 are involved in more than one stage of DC life. Other transcription factors including Ikaros and JAK3 are involved in the development of more than one cell type. For a long time, the cellular and molecular mechanisms underlying the development, differentiation, maturation, and other stages of DC life were not well understood. However, in recent years novel information has been published by many researchers to better understand the molecular mechanisms of the development and function of DCs in immunological diseases such as asthma, cancer, autoimmunity, and transplantation. This review will discuss the various transcription factors and signaling pathways involved in each stage of the life cycle of DCs.

Original languageEnglish
Pages (from-to)79-96
Number of pages18
JournalImmunologic Research
Volume37
Issue number1
DOIs
StatePublished - Jan 2007

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Life Cycle Stages
Dendritic Cells
Cell Cycle
Transcription Factors
Ikaros Transcription Factor
Immune System Diseases
Antigen-Presenting Cells
Autoimmunity
Human Body
Asthma
Transplantation
Research Personnel
T-Lymphocytes
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Transcription factors in the control of dendritic cell life cycle. / Bharadwaj, Arpita S.; Agrawal, Devendra K.

In: Immunologic Research, Vol. 37, No. 1, 01.2007, p. 79-96.

Research output: Contribution to journalReview article

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