Transdermal patch drug delivery interactions with exercise

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Transdermal drug delivery systems, such as the transdermal patch, continue to be a popular and convenient way to administer medications. There are currently several medications that use a transdermal patch drug delivery system. This article describes the potential untoward side effects of increased drug absorption through the use of a transdermal patch in individuals who exercise or participate in sporting events. Four studies have been reported that demonstrate a significant increase in the plasma concentration of nitroglycerin when individuals exercise compared with rest. Likewise, several case reports and two studies have been conducted that demonstrate nicotine toxicity and increased plasma nicotine while wearing a nicotine patch in individuals who exercise or participate in sporting events compared with rest. Healthcare providers, trainers and coaches should be aware of proper transdermal patch use, especially while exercising, in order to provide needed information to their respective patients and athletes to avoid potential untoward side effects. Particular caution should be given to individuals who participate in an extreme sporting event of long duration. Further research that includes more medications is needed in this area.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalSports Medicine
Volume41
Issue number3
DOIs
StatePublished - 2011

Fingerprint

Transdermal Patch
Drug Interactions
Exercise
Drug Delivery Systems
Nicotine
Tobacco Use Cessation Products
Nitroglycerin
Drug-Related Side Effects and Adverse Reactions
Athletes
Health Personnel
Research

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Transdermal patch drug delivery interactions with exercise. / Lenz, Thomas L.; White, Nicole D.

In: Sports Medicine, Vol. 41, No. 3, 2011, p. 177-183.

Research output: Contribution to journalArticle

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