Transmembrane Ca2+ gradient and function of membrane proteins

F. Y. Yang, Y. G. Huang, Y. P. Tu

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


This review will focus on the recent advance in the study of effect of transmembrane Ca2+ gradient on the function of membrane proteins. It consits of two parts: 1. Transmembrane Ca2+ gradient and sarcoplasmic reticulum Ca2+-ATPase; 2. Effect of transmembrane Ca2+ gradient on the components and coupling of cAMP signal transduction pathway. The results obtained indicate that a proper transmembrane Ca2+ gradient may play an important role in modulating the conformation and activity of SR Ca2+-ATPase and the function of membrane proteins involved in the cAMP signal transduction by mediating the physical state change of the membrane phospholipids.

Original languageEnglish (US)
Pages (from-to)351-364
Number of pages14
JournalBioscience Reports
Issue number5
StatePublished - Oct 1 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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