Transmission pathways and mediators as the basis for clinical pharmacology of pain

Daniel R. Kirkpatrick, Dan M. McEntire, Tyler A. Smith, Nicholas P. Dueck, Mitchell J. Kerfeld, Zakary J. Hambsch, Taylor J. Nelson, Mark Reisbig, Devendra K. Agrawal

Research output: Contribution to journalReview article

Abstract

Introduction: Mediators in pain transmission are the targets of a multitude of different analgesic pharmaceuticals. This review explores the most significant mediators of pain transmission as well as the pharmaceuticals that act on them. Areas covered: The review explores many of the key mediators of pain transmission. In doing so, this review uncovers important areas for further research. It also highlights agents with potential for producing novel analgesics, probes important interactions between pain transmission pathways that could contribute to synergistic analgesia, and emphasizes transmission factors that participate in transforming acute injury into chronic pain. Expert commentary: This review examines current pain research, particularly in the context of identifying novel analgesics, highlighting interactions between analgesic transmission pathways, and discussing factors that may contribute to the development of chronic pain after an acute injury.

Original languageEnglish (US)
Pages (from-to)1363-1387
Number of pages25
JournalExpert Review of Clinical Pharmacology
Volume9
Issue number10
DOIs
StatePublished - Oct 2 2016

Fingerprint

Clinical Pharmacology
Analgesics
Pain
Chronic Pain
Wounds and Injuries
Research
Analgesia
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Kirkpatrick, D. R., McEntire, D. M., Smith, T. A., Dueck, N. P., Kerfeld, M. J., Hambsch, Z. J., ... Agrawal, D. K. (2016). Transmission pathways and mediators as the basis for clinical pharmacology of pain. Expert Review of Clinical Pharmacology, 9(10), 1363-1387. https://doi.org/10.1080/17512433.2016.1204231

Transmission pathways and mediators as the basis for clinical pharmacology of pain. / Kirkpatrick, Daniel R.; McEntire, Dan M.; Smith, Tyler A.; Dueck, Nicholas P.; Kerfeld, Mitchell J.; Hambsch, Zakary J.; Nelson, Taylor J.; Reisbig, Mark; Agrawal, Devendra K.

In: Expert Review of Clinical Pharmacology, Vol. 9, No. 10, 02.10.2016, p. 1363-1387.

Research output: Contribution to journalReview article

Kirkpatrick, DR, McEntire, DM, Smith, TA, Dueck, NP, Kerfeld, MJ, Hambsch, ZJ, Nelson, TJ, Reisbig, M & Agrawal, DK 2016, 'Transmission pathways and mediators as the basis for clinical pharmacology of pain', Expert Review of Clinical Pharmacology, vol. 9, no. 10, pp. 1363-1387. https://doi.org/10.1080/17512433.2016.1204231
Kirkpatrick DR, McEntire DM, Smith TA, Dueck NP, Kerfeld MJ, Hambsch ZJ et al. Transmission pathways and mediators as the basis for clinical pharmacology of pain. Expert Review of Clinical Pharmacology. 2016 Oct 2;9(10):1363-1387. https://doi.org/10.1080/17512433.2016.1204231
Kirkpatrick, Daniel R. ; McEntire, Dan M. ; Smith, Tyler A. ; Dueck, Nicholas P. ; Kerfeld, Mitchell J. ; Hambsch, Zakary J. ; Nelson, Taylor J. ; Reisbig, Mark ; Agrawal, Devendra K. / Transmission pathways and mediators as the basis for clinical pharmacology of pain. In: Expert Review of Clinical Pharmacology. 2016 ; Vol. 9, No. 10. pp. 1363-1387.
@article{6246606da14641bd99b8b981229085cc,
title = "Transmission pathways and mediators as the basis for clinical pharmacology of pain",
abstract = "Introduction: Mediators in pain transmission are the targets of a multitude of different analgesic pharmaceuticals. This review explores the most significant mediators of pain transmission as well as the pharmaceuticals that act on them. Areas covered: The review explores many of the key mediators of pain transmission. In doing so, this review uncovers important areas for further research. It also highlights agents with potential for producing novel analgesics, probes important interactions between pain transmission pathways that could contribute to synergistic analgesia, and emphasizes transmission factors that participate in transforming acute injury into chronic pain. Expert commentary: This review examines current pain research, particularly in the context of identifying novel analgesics, highlighting interactions between analgesic transmission pathways, and discussing factors that may contribute to the development of chronic pain after an acute injury.",
author = "Kirkpatrick, {Daniel R.} and McEntire, {Dan M.} and Smith, {Tyler A.} and Dueck, {Nicholas P.} and Kerfeld, {Mitchell J.} and Hambsch, {Zakary J.} and Nelson, {Taylor J.} and Mark Reisbig and Agrawal, {Devendra K.}",
year = "2016",
month = "10",
day = "2",
doi = "10.1080/17512433.2016.1204231",
language = "English (US)",
volume = "9",
pages = "1363--1387",
journal = "Expert Review of Clinical Pharmacology",
issn = "1751-2433",
publisher = "Expert Reviews Ltd.",
number = "10",

}

TY - JOUR

T1 - Transmission pathways and mediators as the basis for clinical pharmacology of pain

AU - Kirkpatrick, Daniel R.

AU - McEntire, Dan M.

AU - Smith, Tyler A.

AU - Dueck, Nicholas P.

AU - Kerfeld, Mitchell J.

AU - Hambsch, Zakary J.

AU - Nelson, Taylor J.

AU - Reisbig, Mark

AU - Agrawal, Devendra K.

PY - 2016/10/2

Y1 - 2016/10/2

N2 - Introduction: Mediators in pain transmission are the targets of a multitude of different analgesic pharmaceuticals. This review explores the most significant mediators of pain transmission as well as the pharmaceuticals that act on them. Areas covered: The review explores many of the key mediators of pain transmission. In doing so, this review uncovers important areas for further research. It also highlights agents with potential for producing novel analgesics, probes important interactions between pain transmission pathways that could contribute to synergistic analgesia, and emphasizes transmission factors that participate in transforming acute injury into chronic pain. Expert commentary: This review examines current pain research, particularly in the context of identifying novel analgesics, highlighting interactions between analgesic transmission pathways, and discussing factors that may contribute to the development of chronic pain after an acute injury.

AB - Introduction: Mediators in pain transmission are the targets of a multitude of different analgesic pharmaceuticals. This review explores the most significant mediators of pain transmission as well as the pharmaceuticals that act on them. Areas covered: The review explores many of the key mediators of pain transmission. In doing so, this review uncovers important areas for further research. It also highlights agents with potential for producing novel analgesics, probes important interactions between pain transmission pathways that could contribute to synergistic analgesia, and emphasizes transmission factors that participate in transforming acute injury into chronic pain. Expert commentary: This review examines current pain research, particularly in the context of identifying novel analgesics, highlighting interactions between analgesic transmission pathways, and discussing factors that may contribute to the development of chronic pain after an acute injury.

UR - http://www.scopus.com/inward/record.url?scp=84988504076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988504076&partnerID=8YFLogxK

U2 - 10.1080/17512433.2016.1204231

DO - 10.1080/17512433.2016.1204231

M3 - Review article

VL - 9

SP - 1363

EP - 1387

JO - Expert Review of Clinical Pharmacology

JF - Expert Review of Clinical Pharmacology

SN - 1751-2433

IS - 10

ER -