Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: Combined results of two double-blind investigations

D. P. Lookingbill, D. K. Chalker, J. S. Lindholm, H. I. Katz, S. E. Kempers, Christopher Huerter, J. M. Swinehart, D. J. Schelling, H. C. Klauda

Research output: Contribution to journalArticle

166 Citations (Scopus)

Abstract

Background: It has previously been shown that a combination of erythromycin and benzoyl peroxide is superior to either ingredient when used alone in the treatment of ache. A clindamycin/benzoyl peroxide combination gel might have an advantage over erythromycin/benzoyl peroxide gel because the former does not require refrigeration after it is dispensed. Objective: Our purpose was to determine the efficacy and safety of a combination clindamycin/benzoyl peroxide gel when compared with benzoyl peroxide, clindamycin, or vehicle gels. Methods: In two double-blind, randomized, parallel, vehicle-controlled trials, patients were treated for 11 weeks with once-nightly application of one of the above preparations. Evaluations were performed at 2, 5, 8, and 11 weeks and included lesion counts and assessment of global responses and irritant effects. Results: A total of 334 patients completed the study. All three active preparations were significantly superior to the vehicle in global improvement and in reducing inflammatory lesions and noninflammatory lesions. The combination gel was significantly superior to the two individual agents in global improvement and reduction of inflammatory lesions and also to the clindamycin gel in reducing noninflammatory lesions. There was no significant difference in tolerance to the active gels versus the vehicle gel. Conclusion: In the treatment of acne, topical clindamycin/benzoyl peroxide combination gel is well tolerated and superior to either individual ingredient.

Original languageEnglish
Pages (from-to)590-595
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume37
Issue number4
DOIs
StatePublished - 1997
Externally publishedYes

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Benzoyl Peroxide
Clindamycin
Acne Vulgaris
Gels
Therapeutics
Refrigeration
Irritants
Safety
Pain

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel : Combined results of two double-blind investigations. / Lookingbill, D. P.; Chalker, D. K.; Lindholm, J. S.; Katz, H. I.; Kempers, S. E.; Huerter, Christopher; Swinehart, J. M.; Schelling, D. J.; Klauda, H. C.

In: Journal of the American Academy of Dermatology, Vol. 37, No. 4, 1997, p. 590-595.

Research output: Contribution to journalArticle

Lookingbill, D. P. ; Chalker, D. K. ; Lindholm, J. S. ; Katz, H. I. ; Kempers, S. E. ; Huerter, Christopher ; Swinehart, J. M. ; Schelling, D. J. ; Klauda, H. C. / Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel : Combined results of two double-blind investigations. In: Journal of the American Academy of Dermatology. 1997 ; Vol. 37, No. 4. pp. 590-595.
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abstract = "Background: It has previously been shown that a combination of erythromycin and benzoyl peroxide is superior to either ingredient when used alone in the treatment of ache. A clindamycin/benzoyl peroxide combination gel might have an advantage over erythromycin/benzoyl peroxide gel because the former does not require refrigeration after it is dispensed. Objective: Our purpose was to determine the efficacy and safety of a combination clindamycin/benzoyl peroxide gel when compared with benzoyl peroxide, clindamycin, or vehicle gels. Methods: In two double-blind, randomized, parallel, vehicle-controlled trials, patients were treated for 11 weeks with once-nightly application of one of the above preparations. Evaluations were performed at 2, 5, 8, and 11 weeks and included lesion counts and assessment of global responses and irritant effects. Results: A total of 334 patients completed the study. All three active preparations were significantly superior to the vehicle in global improvement and in reducing inflammatory lesions and noninflammatory lesions. The combination gel was significantly superior to the two individual agents in global improvement and reduction of inflammatory lesions and also to the clindamycin gel in reducing noninflammatory lesions. There was no significant difference in tolerance to the active gels versus the vehicle gel. Conclusion: In the treatment of acne, topical clindamycin/benzoyl peroxide combination gel is well tolerated and superior to either individual ingredient.",
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AU - Lindholm, J. S.

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