Treatment of childhood kaposiform hemangioendothelioma with sirolimus

Julie Blatt; Joseph Stavas; Billie Moats-Staats; John Woosley; Dean S. Morrell

doi:10.1002/pbc.22766

Treatment of childhood kaposiform hemangioendothelioma with sirolimus

Julie Blatt, Joseph Stavas, Billie Moats-Staats, John Woosley, Dean S. Morrell

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Sirolimus (Rapamune), a mammalian target of Rapamycin (mTOR) inhibitor, which has been used extensively in children following solid organ transplantation, has been demonstrated to have anti-angiogenic activity in pre-clinical models. Limited experience suggests that it may have application to the treatment of vascular lesions. We describe our experience with a 1-year-old female with a kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon who had rapid and dramatic response to sirolimus (0.1mg/kg/day). This case provides further rationale for clinical trials of sirolimus in the treatment of vascular lesions.

Original language	English
Pages (from-to)	1396-1398
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	55
Issue number	7
DOIs	https://doi.org/10.1002/pbc.22766
State	Published - Dec 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Pediatrics, Perinatology, and Child Health
Hematology

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title = "Treatment of childhood kaposiform hemangioendothelioma with sirolimus",

abstract = "Sirolimus (Rapamune), a mammalian target of Rapamycin (mTOR) inhibitor, which has been used extensively in children following solid organ transplantation, has been demonstrated to have anti-angiogenic activity in pre-clinical models. Limited experience suggests that it may have application to the treatment of vascular lesions. We describe our experience with a 1-year-old female with a kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon who had rapid and dramatic response to sirolimus (0.1mg/kg/day). This case provides further rationale for clinical trials of sirolimus in the treatment of vascular lesions.",

author = "Julie Blatt and Joseph Stavas and Billie Moats-Staats and John Woosley and Morrell, {Dean S.}",

year = "2010",

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AU - Blatt, Julie

AU - Stavas, Joseph

AU - Moats-Staats, Billie

AU - Woosley, John

AU - Morrell, Dean S.

PY - 2010/12

Y1 - 2010/12

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AB - Sirolimus (Rapamune), a mammalian target of Rapamycin (mTOR) inhibitor, which has been used extensively in children following solid organ transplantation, has been demonstrated to have anti-angiogenic activity in pre-clinical models. Limited experience suggests that it may have application to the treatment of vascular lesions. We describe our experience with a 1-year-old female with a kaposiform hemangioendothelioma and Kasabach-Merritt phenomenon who had rapid and dramatic response to sirolimus (0.1mg/kg/day). This case provides further rationale for clinical trials of sirolimus in the treatment of vascular lesions.

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Treatment of childhood kaposiform hemangioendothelioma with sirolimus

Abstract

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