Abstract
Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.
| Original language | English |
|---|---|
| Pages (from-to) | 781-785 |
| Number of pages | 5 |
| Journal | Fertility and Sterility |
| Volume | 105 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2016 |
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All Science Journal Classification (ASJC) codes
- Obstetrics and Gynecology
- Reproductive Medicine
- Medicine(all)
Cite this
Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. / Gronwald, Jacek; Glass, Karen; Rosen, Barry; Karlan, Beth; Tung, Nadine; Neuhausen, Susan L.; Moller, Pal; Ainsworth, Peter; Sun, Ping; Narod, Steven A.; Lubinski, Jan; Kotsopoulos, Joanne; Lynch, Henry T.; Cybulski, Cezary; Kim-Sing, Charmaine; Friedman, Susan; Senter, Leigha; Weitzel, Jeffrey; Singer, Christian; Eng, Charis; Mitchell, Gillian; Huzarski, Tomasz; McCuaig, Jeanna; Eisen, Andrea; Gilchrist, Dawna; Blum, Joanne L.; Zakalik, Dana; Pal, Tuya; Daly, Mary; Weber, Barbara; Snyder, Carrie; Fallen, Taya; Chudley, Albert; Lunn, John; Donenberg, Talia; Kurz, Raluca N.; Saal, Howard; Garber, Judy; Rennert, Gad; Sweet, Kevin; Rappaport, Christine; Lemire, Edmond; Stoppa-Lyonnet, Dominique; Olopade, Olufunmilayo I.; Merajver, Sofia; Bordeleau, Louise; Cullinane, Carey A.; Friedman, Eitan; McKinnon, Wendy; Wood, Marie; Rayson, Daniel; Meschino, Wendy; Costalas, Josephine Wagner; Reilly, Robert E.; Vadaparampil, Susan; Offit, Kenneth; Kauff, Noah; Euhus, David; Kwong, Ava; Isaacs, Claudine; Couch, Fergus; Manoukian, Siranoush; Byrski, Tomasz; Elser, Christine; Panchal, Seema; Armel, Susan; Demsky, Rochelle; Nanda, Sonia; Metcalfe, Kelly; Poll, Aletta; Foulkes, William D.; Robidoux, Andre; Warner, Ellen; Maehle, Lovise; Evans, Gareth; Pasini, Barbara; Ginsburg, Ophira; Cohen, Stephanie; Jakubowska, Anna; Little, Janice.
In: Fertility and Sterility, Vol. 105, No. 3, 01.03.2016, p. 781-785.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation
AU - Gronwald, Jacek
AU - Glass, Karen
AU - Rosen, Barry
AU - Karlan, Beth
AU - Tung, Nadine
AU - Neuhausen, Susan L.
AU - Moller, Pal
AU - Ainsworth, Peter
AU - Sun, Ping
AU - Narod, Steven A.
AU - Lubinski, Jan
AU - Kotsopoulos, Joanne
AU - Lynch, Henry T.
AU - Cybulski, Cezary
AU - Kim-Sing, Charmaine
AU - Friedman, Susan
AU - Senter, Leigha
AU - Weitzel, Jeffrey
AU - Singer, Christian
AU - Eng, Charis
AU - Mitchell, Gillian
AU - Huzarski, Tomasz
AU - McCuaig, Jeanna
AU - Eisen, Andrea
AU - Gilchrist, Dawna
AU - Blum, Joanne L.
AU - Zakalik, Dana
AU - Pal, Tuya
AU - Daly, Mary
AU - Weber, Barbara
AU - Snyder, Carrie
AU - Fallen, Taya
AU - Chudley, Albert
AU - Lunn, John
AU - Donenberg, Talia
AU - Kurz, Raluca N.
AU - Saal, Howard
AU - Garber, Judy
AU - Rennert, Gad
AU - Sweet, Kevin
AU - Rappaport, Christine
AU - Lemire, Edmond
AU - Stoppa-Lyonnet, Dominique
AU - Olopade, Olufunmilayo I.
AU - Merajver, Sofia
AU - Bordeleau, Louise
AU - Cullinane, Carey A.
AU - Friedman, Eitan
AU - McKinnon, Wendy
AU - Wood, Marie
AU - Rayson, Daniel
AU - Meschino, Wendy
AU - Costalas, Josephine Wagner
AU - Reilly, Robert E.
AU - Vadaparampil, Susan
AU - Offit, Kenneth
AU - Kauff, Noah
AU - Euhus, David
AU - Kwong, Ava
AU - Isaacs, Claudine
AU - Couch, Fergus
AU - Manoukian, Siranoush
AU - Byrski, Tomasz
AU - Elser, Christine
AU - Panchal, Seema
AU - Armel, Susan
AU - Demsky, Rochelle
AU - Nanda, Sonia
AU - Metcalfe, Kelly
AU - Poll, Aletta
AU - Foulkes, William D.
AU - Robidoux, Andre
AU - Warner, Ellen
AU - Maehle, Lovise
AU - Evans, Gareth
AU - Pasini, Barbara
AU - Ginsburg, Ophira
AU - Cohen, Stephanie
AU - Jakubowska, Anna
AU - Little, Janice
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.
AB - Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.
UR - http://www.scopus.com/inward/record.url?scp=84959265661&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959265661&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2015.11.034
DO - 10.1016/j.fertnstert.2015.11.034
M3 - Article
C2 - 26698676
AN - SCOPUS:84959265661
VL - 105
SP - 781
EP - 785
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 3
ER -