Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

Jacek Gronwald, Karen Glass, Barry Rosen, Beth Karlan, Nadine Tung, Susan L. Neuhausen, Pal Moller, Peter Ainsworth, Ping Sun, Steven A. Narod, Jan Lubinski, Joanne Kotsopoulos, Henry T. Lynch, Cezary Cybulski, Charmaine Kim-Sing, Susan Friedman, Leigha Senter, Jeffrey Weitzel, Christian Singer, Charis Eng & 60 others Gillian Mitchell, Tomasz Huzarski, Jeanna McCuaig, Andrea Eisen, Dawna Gilchrist, Joanne L. Blum, Dana Zakalik, Tuya Pal, Mary Daly, Barbara Weber, Carrie Snyder, Taya Fallen, Albert Chudley, John Lunn, Talia Donenberg, Raluca N. Kurz, Howard Saal, Judy Garber, Gad Rennert, Kevin Sweet, Christine Rappaport, Edmond Lemire, Dominique Stoppa-Lyonnet, Olufunmilayo I. Olopade, Sofia Merajver, Louise Bordeleau, Carey A. Cullinane, Eitan Friedman, Wendy McKinnon, Marie Wood, Daniel Rayson, Wendy Meschino, Josephine Wagner Costalas, Robert E. Reilly, Susan Vadaparampil, Kenneth Offit, Noah Kauff, David Euhus, Ava Kwong, Claudine Isaacs, Fergus Couch, Siranoush Manoukian, Tomasz Byrski, Christine Elser, Seema Panchal, Susan Armel, Rochelle Demsky, Sonia Nanda, Kelly Metcalfe, Aletta Poll, William D. Foulkes, Andre Robidoux, Ellen Warner, Lovise Maehle, Gareth Evans, Barbara Pasini, Ophira Ginsburg, Stephanie Cohen, Anna Jakubowska, Janice Little

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.

Original languageEnglish
Pages (from-to)781-785
Number of pages5
JournalFertility and Sterility
Volume105
Issue number3
DOIs
StatePublished - Mar 1 2016

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Ovarian Neoplasms
Infertility
Mutation
Fertility
Odds Ratio
Confidence Intervals
Selective Estrogen Receptor Modulators
Therapeutics
Gonadotropins
Case-Control Studies
Logistic Models
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. / Gronwald, Jacek; Glass, Karen; Rosen, Barry; Karlan, Beth; Tung, Nadine; Neuhausen, Susan L.; Moller, Pal; Ainsworth, Peter; Sun, Ping; Narod, Steven A.; Lubinski, Jan; Kotsopoulos, Joanne; Lynch, Henry T.; Cybulski, Cezary; Kim-Sing, Charmaine; Friedman, Susan; Senter, Leigha; Weitzel, Jeffrey; Singer, Christian; Eng, Charis; Mitchell, Gillian; Huzarski, Tomasz; McCuaig, Jeanna; Eisen, Andrea; Gilchrist, Dawna; Blum, Joanne L.; Zakalik, Dana; Pal, Tuya; Daly, Mary; Weber, Barbara; Snyder, Carrie; Fallen, Taya; Chudley, Albert; Lunn, John; Donenberg, Talia; Kurz, Raluca N.; Saal, Howard; Garber, Judy; Rennert, Gad; Sweet, Kevin; Rappaport, Christine; Lemire, Edmond; Stoppa-Lyonnet, Dominique; Olopade, Olufunmilayo I.; Merajver, Sofia; Bordeleau, Louise; Cullinane, Carey A.; Friedman, Eitan; McKinnon, Wendy; Wood, Marie; Rayson, Daniel; Meschino, Wendy; Costalas, Josephine Wagner; Reilly, Robert E.; Vadaparampil, Susan; Offit, Kenneth; Kauff, Noah; Euhus, David; Kwong, Ava; Isaacs, Claudine; Couch, Fergus; Manoukian, Siranoush; Byrski, Tomasz; Elser, Christine; Panchal, Seema; Armel, Susan; Demsky, Rochelle; Nanda, Sonia; Metcalfe, Kelly; Poll, Aletta; Foulkes, William D.; Robidoux, Andre; Warner, Ellen; Maehle, Lovise; Evans, Gareth; Pasini, Barbara; Ginsburg, Ophira; Cohen, Stephanie; Jakubowska, Anna; Little, Janice.

In: Fertility and Sterility, Vol. 105, No. 3, 01.03.2016, p. 781-785.

Research output: Contribution to journalArticle

Gronwald, J, Glass, K, Rosen, B, Karlan, B, Tung, N, Neuhausen, SL, Moller, P, Ainsworth, P, Sun, P, Narod, SA, Lubinski, J, Kotsopoulos, J, Lynch, HT, Cybulski, C, Kim-Sing, C, Friedman, S, Senter, L, Weitzel, J, Singer, C, Eng, C, Mitchell, G, Huzarski, T, McCuaig, J, Eisen, A, Gilchrist, D, Blum, JL, Zakalik, D, Pal, T, Daly, M, Weber, B, Snyder, C, Fallen, T, Chudley, A, Lunn, J, Donenberg, T, Kurz, RN, Saal, H, Garber, J, Rennert, G, Sweet, K, Rappaport, C, Lemire, E, Stoppa-Lyonnet, D, Olopade, OI, Merajver, S, Bordeleau, L, Cullinane, CA, Friedman, E, McKinnon, W, Wood, M, Rayson, D, Meschino, W, Costalas, JW, Reilly, RE, Vadaparampil, S, Offit, K, Kauff, N, Euhus, D, Kwong, A, Isaacs, C, Couch, F, Manoukian, S, Byrski, T, Elser, C, Panchal, S, Armel, S, Demsky, R, Nanda, S, Metcalfe, K, Poll, A, Foulkes, WD, Robidoux, A, Warner, E, Maehle, L, Evans, G, Pasini, B, Ginsburg, O, Cohen, S, Jakubowska, A & Little, J 2016, 'Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation', Fertility and Sterility, vol. 105, no. 3, pp. 781-785. https://doi.org/10.1016/j.fertnstert.2015.11.034
Gronwald, Jacek ; Glass, Karen ; Rosen, Barry ; Karlan, Beth ; Tung, Nadine ; Neuhausen, Susan L. ; Moller, Pal ; Ainsworth, Peter ; Sun, Ping ; Narod, Steven A. ; Lubinski, Jan ; Kotsopoulos, Joanne ; Lynch, Henry T. ; Cybulski, Cezary ; Kim-Sing, Charmaine ; Friedman, Susan ; Senter, Leigha ; Weitzel, Jeffrey ; Singer, Christian ; Eng, Charis ; Mitchell, Gillian ; Huzarski, Tomasz ; McCuaig, Jeanna ; Eisen, Andrea ; Gilchrist, Dawna ; Blum, Joanne L. ; Zakalik, Dana ; Pal, Tuya ; Daly, Mary ; Weber, Barbara ; Snyder, Carrie ; Fallen, Taya ; Chudley, Albert ; Lunn, John ; Donenberg, Talia ; Kurz, Raluca N. ; Saal, Howard ; Garber, Judy ; Rennert, Gad ; Sweet, Kevin ; Rappaport, Christine ; Lemire, Edmond ; Stoppa-Lyonnet, Dominique ; Olopade, Olufunmilayo I. ; Merajver, Sofia ; Bordeleau, Louise ; Cullinane, Carey A. ; Friedman, Eitan ; McKinnon, Wendy ; Wood, Marie ; Rayson, Daniel ; Meschino, Wendy ; Costalas, Josephine Wagner ; Reilly, Robert E. ; Vadaparampil, Susan ; Offit, Kenneth ; Kauff, Noah ; Euhus, David ; Kwong, Ava ; Isaacs, Claudine ; Couch, Fergus ; Manoukian, Siranoush ; Byrski, Tomasz ; Elser, Christine ; Panchal, Seema ; Armel, Susan ; Demsky, Rochelle ; Nanda, Sonia ; Metcalfe, Kelly ; Poll, Aletta ; Foulkes, William D. ; Robidoux, Andre ; Warner, Ellen ; Maehle, Lovise ; Evans, Gareth ; Pasini, Barbara ; Ginsburg, Ophira ; Cohen, Stephanie ; Jakubowska, Anna ; Little, Janice. / Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. In: Fertility and Sterility. 2016 ; Vol. 105, No. 3. pp. 781-785.
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AU - Gronwald, Jacek

AU - Glass, Karen

AU - Rosen, Barry

AU - Karlan, Beth

AU - Tung, Nadine

AU - Neuhausen, Susan L.

AU - Moller, Pal

AU - Ainsworth, Peter

AU - Sun, Ping

AU - Narod, Steven A.

AU - Lubinski, Jan

AU - Kotsopoulos, Joanne

AU - Lynch, Henry T.

AU - Cybulski, Cezary

AU - Kim-Sing, Charmaine

AU - Friedman, Susan

AU - Senter, Leigha

AU - Weitzel, Jeffrey

AU - Singer, Christian

AU - Eng, Charis

AU - Mitchell, Gillian

AU - Huzarski, Tomasz

AU - McCuaig, Jeanna

AU - Eisen, Andrea

AU - Gilchrist, Dawna

AU - Blum, Joanne L.

AU - Zakalik, Dana

AU - Pal, Tuya

AU - Daly, Mary

AU - Weber, Barbara

AU - Snyder, Carrie

AU - Fallen, Taya

AU - Chudley, Albert

AU - Lunn, John

AU - Donenberg, Talia

AU - Kurz, Raluca N.

AU - Saal, Howard

AU - Garber, Judy

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AU - Sweet, Kevin

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AU - Lemire, Edmond

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AU - Merajver, Sofia

AU - Bordeleau, Louise

AU - Cullinane, Carey A.

AU - Friedman, Eitan

AU - McKinnon, Wendy

AU - Wood, Marie

AU - Rayson, Daniel

AU - Meschino, Wendy

AU - Costalas, Josephine Wagner

AU - Reilly, Robert E.

AU - Vadaparampil, Susan

AU - Offit, Kenneth

AU - Kauff, Noah

AU - Euhus, David

AU - Kwong, Ava

AU - Isaacs, Claudine

AU - Couch, Fergus

AU - Manoukian, Siranoush

AU - Byrski, Tomasz

AU - Elser, Christine

AU - Panchal, Seema

AU - Armel, Susan

AU - Demsky, Rochelle

AU - Nanda, Sonia

AU - Metcalfe, Kelly

AU - Poll, Aletta

AU - Foulkes, William D.

AU - Robidoux, Andre

AU - Warner, Ellen

AU - Maehle, Lovise

AU - Evans, Gareth

AU - Pasini, Barbara

AU - Ginsburg, Ophira

AU - Cohen, Stephanie

AU - Jakubowska, Anna

AU - Little, Janice

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