Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

Jacek Gronwald; Karen Glass; Barry Rosen; Beth Karlan; Nadine Tung; Susan L. Neuhausen; Pal Moller; Peter Ainsworth; Ping Sun; Steven A. Narod; Jan Lubinski; Joanne Kotsopoulos; Henry T. Lynch; Cezary Cybulski; Charmaine Kim-Sing; Susan Friedman; Leigha Senter; Jeffrey Weitzel; Christian Singer; Charis Eng; Gillian Mitchell; Tomasz Huzarski; Jeanna McCuaig; Andrea Eisen; Dawna Gilchrist; Joanne L. Blum; Dana Zakalik; Tuya Pal; Mary Daly; Barbara Weber; Carrie Snyder; Taya Fallen; Albert Chudley; John Lunn; Talia Donenberg; Raluca N. Kurz; Howard Saal; Judy Garber; Gad Rennert; Kevin Sweet; Christine Rappaport; Edmond Lemire; Dominique Stoppa-Lyonnet; Olufunmilayo I. Olopade; Sofia Merajver; Louise Bordeleau; Carey A. Cullinane; Eitan Friedman; Wendy McKinnon; Marie Wood; Daniel Rayson; Wendy Meschino; Josephine Wagner Costalas; Robert E. Reilly; Susan Vadaparampil; Kenneth Offit; Noah Kauff; David Euhus; Ava Kwong; Claudine Isaacs; Fergus Couch; Siranoush Manoukian; Tomasz Byrski; Christine Elser; Seema Panchal; Susan Armel; Rochelle Demsky; Sonia Nanda; Kelly Metcalfe; Aletta Poll; William D. Foulkes; Andre Robidoux; Ellen Warner; Lovise Maehle; Gareth Evans; Barbara Pasini; Ophira Ginsburg; Stephanie Cohen; Anna Jakubowska; Janice Little

doi:10.1016/j.fertnstert.2015.11.034

Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

Jacek Gronwald, Karen Glass, Barry Rosen, Beth Karlan, Nadine Tung, Susan L. Neuhausen, Pal Moller, Peter Ainsworth, Ping Sun, Steven A. Narod, Jan Lubinski, Joanne Kotsopoulos, Henry T. Lynch, Cezary Cybulski, Charmaine Kim-Sing, Susan Friedman, Leigha Senter, Jeffrey Weitzel, Christian Singer, Charis EngGillian Mitchell, Tomasz Huzarski, Jeanna McCuaig, Andrea Eisen, Dawna Gilchrist, Joanne L. Blum, Dana Zakalik, Tuya Pal, Mary Daly, Barbara Weber, Carrie Snyder, Taya Fallen, Albert Chudley, John Lunn, Talia Donenberg, Raluca N. Kurz, Howard Saal, Judy Garber, Gad Rennert, Kevin Sweet, Christine Rappaport, Edmond Lemire, Dominique Stoppa-Lyonnet, Olufunmilayo I. Olopade, Sofia Merajver, Louise Bordeleau, Carey A. Cullinane, Eitan Friedman, Wendy McKinnon, Marie Wood, Daniel Rayson, Wendy Meschino, Josephine Wagner Costalas, Robert E. Reilly, Susan Vadaparampil, Kenneth Offit, Noah Kauff, David Euhus, Ava Kwong, Claudine Isaacs, Fergus Couch, Siranoush Manoukian, Tomasz Byrski, Christine Elser, Seema Panchal, Susan Armel, Rochelle Demsky, Sonia Nanda, Kelly Metcalfe, Aletta Poll, William D. Foulkes, Andre Robidoux, Ellen Warner, Lovise Maehle, Gareth Evans, Barbara Pasini, Ophira Ginsburg, Stephanie Cohen, Anna Jakubowska, Janice Little

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.

Original language	English (US)
Pages (from-to)	781-785
Number of pages	5
Journal	Fertility and Sterility
Volume	105
Issue number	3
DOIs	https://doi.org/10.1016/j.fertnstert.2015.11.034
State	Published - Mar 1 2016

All Science Journal Classification (ASJC) codes

Reproductive Medicine
Obstetrics and Gynecology

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Gronwald, J., Glass, K., Rosen, B., Karlan, B., Tung, N., Neuhausen, S. L., Moller, P., Ainsworth, P., Sun, P., Narod, S. A., Lubinski, J., Kotsopoulos, J., Lynch, H. T., Cybulski, C., Kim-Sing, C., Friedman, S., Senter, L., Weitzel, J., Singer, C., ... Little, J. (2016). Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Fertility and Sterility, 105(3), 781-785. https://doi.org/10.1016/j.fertnstert.2015.11.034

Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. / Gronwald, Jacek; Glass, Karen; Rosen, Barry; Karlan, Beth; Tung, Nadine; Neuhausen, Susan L.; Moller, Pal; Ainsworth, Peter; Sun, Ping; Narod, Steven A.; Lubinski, Jan; Kotsopoulos, Joanne; Lynch, Henry T.; Cybulski, Cezary; Kim-Sing, Charmaine; Friedman, Susan; Senter, Leigha; Weitzel, Jeffrey; Singer, Christian; Eng, Charis; Mitchell, Gillian; Huzarski, Tomasz; McCuaig, Jeanna; Eisen, Andrea; Gilchrist, Dawna; Blum, Joanne L.; Zakalik, Dana; Pal, Tuya; Daly, Mary; Weber, Barbara; Snyder, Carrie; Fallen, Taya; Chudley, Albert; Lunn, John; Donenberg, Talia; Kurz, Raluca N.; Saal, Howard; Garber, Judy; Rennert, Gad; Sweet, Kevin; Rappaport, Christine; Lemire, Edmond; Stoppa-Lyonnet, Dominique; Olopade, Olufunmilayo I.; Merajver, Sofia; Bordeleau, Louise; Cullinane, Carey A.; Friedman, Eitan; McKinnon, Wendy; Wood, Marie; Rayson, Daniel; Meschino, Wendy; Costalas, Josephine Wagner; Reilly, Robert E.; Vadaparampil, Susan; Offit, Kenneth; Kauff, Noah; Euhus, David; Kwong, Ava; Isaacs, Claudine; Couch, Fergus; Manoukian, Siranoush; Byrski, Tomasz; Elser, Christine; Panchal, Seema; Armel, Susan; Demsky, Rochelle; Nanda, Sonia; Metcalfe, Kelly; Poll, Aletta; Foulkes, William D.; Robidoux, Andre; Warner, Ellen; Maehle, Lovise; Evans, Gareth; Pasini, Barbara; Ginsburg, Ophira; Cohen, Stephanie; Jakubowska, Anna; Little, Janice.

In: Fertility and Sterility, Vol. 105, No. 3, 01.03.2016, p. 781-785.

Research output: Contribution to journal › Article › peer-review

Gronwald, J, Glass, K, Rosen, B, Karlan, B, Tung, N, Neuhausen, SL, Moller, P, Ainsworth, P, Sun, P, Narod, SA, Lubinski, J, Kotsopoulos, J, Lynch, HT, Cybulski, C, Kim-Sing, C, Friedman, S, Senter, L, Weitzel, J, Singer, C, Eng, C, Mitchell, G, Huzarski, T, McCuaig, J, Eisen, A, Gilchrist, D, Blum, JL, Zakalik, D, Pal, T, Daly, M, Weber, B, Snyder, C, Fallen, T, Chudley, A, Lunn, J, Donenberg, T, Kurz, RN, Saal, H, Garber, J, Rennert, G, Sweet, K, Rappaport, C, Lemire, E, Stoppa-Lyonnet, D, Olopade, OI, Merajver, S, Bordeleau, L, Cullinane, CA, Friedman, E, McKinnon, W, Wood, M, Rayson, D, Meschino, W, Costalas, JW, Reilly, RE, Vadaparampil, S, Offit, K, Kauff, N, Euhus, D, Kwong, A, Isaacs, C, Couch, F, Manoukian, S, Byrski, T, Elser, C, Panchal, S, Armel, S, Demsky, R, Nanda, S, Metcalfe, K, Poll, A, Foulkes, WD, Robidoux, A, Warner, E, Maehle, L, Evans, G, Pasini, B, Ginsburg, O, Cohen, S, Jakubowska, A & Little, J 2016, 'Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation', Fertility and Sterility, vol. 105, no. 3, pp. 781-785. https://doi.org/10.1016/j.fertnstert.2015.11.034

Gronwald, Jacek ; Glass, Karen ; Rosen, Barry ; Karlan, Beth ; Tung, Nadine ; Neuhausen, Susan L. ; Moller, Pal ; Ainsworth, Peter ; Sun, Ping ; Narod, Steven A. ; Lubinski, Jan ; Kotsopoulos, Joanne ; Lynch, Henry T. ; Cybulski, Cezary ; Kim-Sing, Charmaine ; Friedman, Susan ; Senter, Leigha ; Weitzel, Jeffrey ; Singer, Christian ; Eng, Charis ; Mitchell, Gillian ; Huzarski, Tomasz ; McCuaig, Jeanna ; Eisen, Andrea ; Gilchrist, Dawna ; Blum, Joanne L. ; Zakalik, Dana ; Pal, Tuya ; Daly, Mary ; Weber, Barbara ; Snyder, Carrie ; Fallen, Taya ; Chudley, Albert ; Lunn, John ; Donenberg, Talia ; Kurz, Raluca N. ; Saal, Howard ; Garber, Judy ; Rennert, Gad ; Sweet, Kevin ; Rappaport, Christine ; Lemire, Edmond ; Stoppa-Lyonnet, Dominique ; Olopade, Olufunmilayo I. ; Merajver, Sofia ; Bordeleau, Louise ; Cullinane, Carey A. ; Friedman, Eitan ; McKinnon, Wendy ; Wood, Marie ; Rayson, Daniel ; Meschino, Wendy ; Costalas, Josephine Wagner ; Reilly, Robert E. ; Vadaparampil, Susan ; Offit, Kenneth ; Kauff, Noah ; Euhus, David ; Kwong, Ava ; Isaacs, Claudine ; Couch, Fergus ; Manoukian, Siranoush ; Byrski, Tomasz ; Elser, Christine ; Panchal, Seema ; Armel, Susan ; Demsky, Rochelle ; Nanda, Sonia ; Metcalfe, Kelly ; Poll, Aletta ; Foulkes, William D. ; Robidoux, Andre ; Warner, Ellen ; Maehle, Lovise ; Evans, Gareth ; Pasini, Barbara ; Ginsburg, Ophira ; Cohen, Stephanie ; Jakubowska, Anna ; Little, Janice. / Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. In: Fertility and Sterility. 2016 ; Vol. 105, No. 3. pp. 781-785.

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title = "Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation",

abstract = "Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.",

author = "Jacek Gronwald and Karen Glass and Barry Rosen and Beth Karlan and Nadine Tung and Neuhausen, {Susan L.} and Pal Moller and Peter Ainsworth and Ping Sun and Narod, {Steven A.} and Jan Lubinski and Joanne Kotsopoulos and Lynch, {Henry T.} and Cezary Cybulski and Charmaine Kim-Sing and Susan Friedman and Leigha Senter and Jeffrey Weitzel and Christian Singer and Charis Eng and Gillian Mitchell and Tomasz Huzarski and Jeanna McCuaig and Andrea Eisen and Dawna Gilchrist and Blum, {Joanne L.} and Dana Zakalik and Tuya Pal and Mary Daly and Barbara Weber and Carrie Snyder and Taya Fallen and Albert Chudley and John Lunn and Talia Donenberg and Kurz, {Raluca N.} and Howard Saal and Judy Garber and Gad Rennert and Kevin Sweet and Christine Rappaport and Edmond Lemire and Dominique Stoppa-Lyonnet and Olopade, {Olufunmilayo I.} and Sofia Merajver and Louise Bordeleau and Cullinane, {Carey A.} and Eitan Friedman and Wendy McKinnon and Marie Wood and Daniel Rayson and Wendy Meschino and Costalas, {Josephine Wagner} and Reilly, {Robert E.} and Susan Vadaparampil and Kenneth Offit and Noah Kauff and David Euhus and Ava Kwong and Claudine Isaacs and Fergus Couch and Siranoush Manoukian and Tomasz Byrski and Christine Elser and Seema Panchal and Susan Armel and Rochelle Demsky and Sonia Nanda and Kelly Metcalfe and Aletta Poll and Foulkes, {William D.} and Andre Robidoux and Ellen Warner and Lovise Maehle and Gareth Evans and Barbara Pasini and Ophira Ginsburg and Stephanie Cohen and Anna Jakubowska and Janice Little",

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T1 - Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

AU - Gronwald, Jacek

AU - Glass, Karen

AU - Rosen, Barry

AU - Karlan, Beth

AU - Tung, Nadine

AU - Neuhausen, Susan L.

AU - Moller, Pal

AU - Ainsworth, Peter

AU - Sun, Ping

AU - Narod, Steven A.

AU - Lubinski, Jan

AU - Kotsopoulos, Joanne

AU - Lynch, Henry T.

AU - Cybulski, Cezary

AU - Kim-Sing, Charmaine

AU - Friedman, Susan

AU - Senter, Leigha

AU - Weitzel, Jeffrey

AU - Singer, Christian

AU - Eng, Charis

AU - Mitchell, Gillian

AU - Huzarski, Tomasz

AU - McCuaig, Jeanna

AU - Eisen, Andrea

AU - Gilchrist, Dawna

AU - Blum, Joanne L.

AU - Zakalik, Dana

AU - Pal, Tuya

AU - Daly, Mary

AU - Weber, Barbara

AU - Snyder, Carrie

AU - Fallen, Taya

AU - Chudley, Albert

AU - Lunn, John

AU - Donenberg, Talia

AU - Kurz, Raluca N.

AU - Saal, Howard

AU - Garber, Judy

AU - Rennert, Gad

AU - Sweet, Kevin

AU - Rappaport, Christine

AU - Lemire, Edmond

AU - Stoppa-Lyonnet, Dominique

AU - Olopade, Olufunmilayo I.

AU - Merajver, Sofia

AU - Bordeleau, Louise

AU - Cullinane, Carey A.

AU - Friedman, Eitan

AU - McKinnon, Wendy

AU - Wood, Marie

AU - Rayson, Daniel

AU - Meschino, Wendy

AU - Costalas, Josephine Wagner

AU - Reilly, Robert E.

AU - Vadaparampil, Susan

AU - Offit, Kenneth

AU - Kauff, Noah

AU - Euhus, David

AU - Kwong, Ava

AU - Isaacs, Claudine

AU - Couch, Fergus

AU - Manoukian, Siranoush

AU - Byrski, Tomasz

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AU - Panchal, Seema

AU - Armel, Susan

AU - Demsky, Rochelle

AU - Nanda, Sonia

AU - Metcalfe, Kelly

AU - Poll, Aletta

AU - Foulkes, William D.

AU - Robidoux, Andre

AU - Warner, Ellen

AU - Maehle, Lovise

AU - Evans, Gareth

AU - Pasini, Barbara

AU - Ginsburg, Ophira

AU - Cohen, Stephanie

AU - Jakubowska, Anna

AU - Little, Janice

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N2 - Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.

AB - Objective To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gonadotropin, or other) or infertility treatment (i.e., IVF or IUI) and the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Design A matched case-control study of 941 pairs of BRCA1 or BRCA2 mutation carriers with and without a diagnosis of ovarian cancer. Setting Genetic clinics. Patient(s) Detailed information regarding treatment of infertility was collected from a routinely administered questionnaire. Intervention(s) None. Main Outcome Measure(s) Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals associated with fertility treatment. Result(s) There was no significant relationship between the use of any fertility medication or IVF treatment (odds ratio, 0.66; 95% confidence interval 0.18-2.33) and the subsequent risk of ovarian cancer. Conclusion(s) Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.

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Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation

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