Abstract
Objective: To investigate the potential role of serum and alveolar soluble triggering receptor expressed on myeloid cells (sTREM-1) as a biological marker of pulmonary aspiration syndromes. Design: Prospective cohort study. Setting: University-affiliated intensive care unit. Patients: Seventy-five patients with pulmonary aspiration and 13 controls receiving mechanical ventilation. Interventions: Blood and bronchoalveolar lavage (BAL) fluid samples were collected on enrollment. Soluble TREM-1 levels were measured by an enzyme-linked immunosorbent assay. Measurements and results: Thirty-eight of 75 participants had documented BAL culture-positive pulmonary aspiration. While circulating levels of sTREM-1 were comparable between those with aspiration syndromes (19.81 ± 12.09 pg/ml) and controls (15.96 ± 11.16 pg/ml) (p = 0.27), the alveolar levels of sTREM-1 were higher in patients with culture-positive pulmonary aspiration (344.41 ± 152.82 pg/ml) compared with those culture-negative pulmonary aspiration (142.76 ± 89.88 pg/ml; p <0.001). A cut-off value of 250 pg/ml for alveolar sTREM-1 achieved a sensitivity of 65.8% (95% CI 48.6-80.4) and a specificity of 91.9% (95% CI 78.1-98.2) with an area under the curve of 0.87 (95% CI 0.78-0.94). Conclusions: Alveolar sTREM-1 levels can be a potential biomarker for distinguishing BAL culture-positive from BAL culture-negative pulmonary aspiration.
| Original language | English |
|---|---|
| Pages (from-to) | 1012-1019 |
| Number of pages | 8 |
| Journal | Intensive Care Medicine |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2008 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Critical Care and Intensive Care Medicine
Cite this
Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes. / El Solh, Ali A.; Akinnusi, Morohunfolu E.; Peter, Misha; Berim, Ilya; Schultz, Marcus J.; Pineda, Lilibeth.
In: Intensive Care Medicine, Vol. 34, No. 6, 06.2008, p. 1012-1019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Triggering receptors expressed on myeloid cells in pulmonary aspiration syndromes
AU - El Solh, Ali A.
AU - Akinnusi, Morohunfolu E.
AU - Peter, Misha
AU - Berim, Ilya
AU - Schultz, Marcus J.
AU - Pineda, Lilibeth
PY - 2008/6
Y1 - 2008/6
N2 - Objective: To investigate the potential role of serum and alveolar soluble triggering receptor expressed on myeloid cells (sTREM-1) as a biological marker of pulmonary aspiration syndromes. Design: Prospective cohort study. Setting: University-affiliated intensive care unit. Patients: Seventy-five patients with pulmonary aspiration and 13 controls receiving mechanical ventilation. Interventions: Blood and bronchoalveolar lavage (BAL) fluid samples were collected on enrollment. Soluble TREM-1 levels were measured by an enzyme-linked immunosorbent assay. Measurements and results: Thirty-eight of 75 participants had documented BAL culture-positive pulmonary aspiration. While circulating levels of sTREM-1 were comparable between those with aspiration syndromes (19.81 ± 12.09 pg/ml) and controls (15.96 ± 11.16 pg/ml) (p = 0.27), the alveolar levels of sTREM-1 were higher in patients with culture-positive pulmonary aspiration (344.41 ± 152.82 pg/ml) compared with those culture-negative pulmonary aspiration (142.76 ± 89.88 pg/ml; p <0.001). A cut-off value of 250 pg/ml for alveolar sTREM-1 achieved a sensitivity of 65.8% (95% CI 48.6-80.4) and a specificity of 91.9% (95% CI 78.1-98.2) with an area under the curve of 0.87 (95% CI 0.78-0.94). Conclusions: Alveolar sTREM-1 levels can be a potential biomarker for distinguishing BAL culture-positive from BAL culture-negative pulmonary aspiration.
AB - Objective: To investigate the potential role of serum and alveolar soluble triggering receptor expressed on myeloid cells (sTREM-1) as a biological marker of pulmonary aspiration syndromes. Design: Prospective cohort study. Setting: University-affiliated intensive care unit. Patients: Seventy-five patients with pulmonary aspiration and 13 controls receiving mechanical ventilation. Interventions: Blood and bronchoalveolar lavage (BAL) fluid samples were collected on enrollment. Soluble TREM-1 levels were measured by an enzyme-linked immunosorbent assay. Measurements and results: Thirty-eight of 75 participants had documented BAL culture-positive pulmonary aspiration. While circulating levels of sTREM-1 were comparable between those with aspiration syndromes (19.81 ± 12.09 pg/ml) and controls (15.96 ± 11.16 pg/ml) (p = 0.27), the alveolar levels of sTREM-1 were higher in patients with culture-positive pulmonary aspiration (344.41 ± 152.82 pg/ml) compared with those culture-negative pulmonary aspiration (142.76 ± 89.88 pg/ml; p <0.001). A cut-off value of 250 pg/ml for alveolar sTREM-1 achieved a sensitivity of 65.8% (95% CI 48.6-80.4) and a specificity of 91.9% (95% CI 78.1-98.2) with an area under the curve of 0.87 (95% CI 0.78-0.94). Conclusions: Alveolar sTREM-1 levels can be a potential biomarker for distinguishing BAL culture-positive from BAL culture-negative pulmonary aspiration.
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U2 - 10.1007/s00134-008-1087-7
DO - 10.1007/s00134-008-1087-7
M3 - Article
C2 - 18392807
AN - SCOPUS:46149100025
VL - 34
SP - 1012
EP - 1019
JO - Intensive Care Medicine
JF - Intensive Care Medicine
SN - 0342-4642
IS - 6
ER -