Trophic effect of norepinephrine on the rat portal vein in organ culture

Peter W. Abel, A. Trapani, O. Aprigliano, K. Hermsmeyer

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rat portal veins were maintained in organ culture to study the development of characteristic denervation changes and a possible trophic effect of the neurotransmitter norepinephrine (NE). Vessels maintained in organ culture for 2 days showed suppersensitivity to NE and Ba2+, a more rapid rate of relaxation from a Ba2+ contracture, and partial depolarization of the myovascular cells. All of these changes except the quicker relaxation from Ba2+ contracture could be prevented by incubating the preparations in a NE-containing medium. This evidence suggests that functional changes in vascular muscle cells are caused by the removal of a trophic influence of NE, but can be prevented by NE replacement. However, the failure of NE in the culture media to prevent the increased rate of relaxation from Ba2+ contracture found after 2 days in organ culture suggests that NE is not the only trophic influence acting on the portal vein. In addition, incubation of veins in a NE-containing medium produced a marked subsensitivity to the contractile effects of NE, but not Ba2+, and thus possible desensitization of noradrenergic receptors. The data thus support a trophic role for NE in the rat portal vein.

Original languageEnglish
Pages (from-to)770-775
Number of pages6
JournalCirculation Research
Volume47
Issue number5
StatePublished - 1980
Externally publishedYes

Fingerprint

Organ Culture Techniques
Portal Vein
Norepinephrine
Contracture
Denervation
Muscle Cells
Neurotransmitter Agents
Blood Vessels
Culture Media
Veins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Abel, P. W., Trapani, A., Aprigliano, O., & Hermsmeyer, K. (1980). Trophic effect of norepinephrine on the rat portal vein in organ culture. Circulation Research, 47(5), 770-775.

Trophic effect of norepinephrine on the rat portal vein in organ culture. / Abel, Peter W.; Trapani, A.; Aprigliano, O.; Hermsmeyer, K.

In: Circulation Research, Vol. 47, No. 5, 1980, p. 770-775.

Research output: Contribution to journalArticle

Abel, PW, Trapani, A, Aprigliano, O & Hermsmeyer, K 1980, 'Trophic effect of norepinephrine on the rat portal vein in organ culture', Circulation Research, vol. 47, no. 5, pp. 770-775.
Abel, Peter W. ; Trapani, A. ; Aprigliano, O. ; Hermsmeyer, K. / Trophic effect of norepinephrine on the rat portal vein in organ culture. In: Circulation Research. 1980 ; Vol. 47, No. 5. pp. 770-775.
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