Tumor variation in three extended Lynch syndrome II kindreds

Henry T. Lynch, J. Ens, J. F. Lynch, P. Watson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Lynch syndrome II is characterized by an autosomal dominantly inherited susceptibility to early onset colon cancer with proximal predominance, an excess of synchronous and metachronous colonic cancer, carcinoma of the endometrium, ovary, and multiple primary cancer excess. Knowledge of the full tumor spectrum in this disorder(s) remains elusive. Cancers that are uncommon in this disease, but present in three extended Lynch syndrome II families, included brain tumors, carcinoma of the bile duct, duodenum, the urological system, and breasts. Long-term followup of these families (as long as two decades) provided the opportunity to trace in depth this tumor spectrum. Full scrutiny of cancer of all anatomic sites in the absence of biomarkers of high sensitivity and specificity to the cancer-prone genotype will be necessary to comprehend more clearly whether these (or other) cancer sites are integral to this disorder, whether common environmental exposures are involved and, finally, whether chance can explain these cancer associations.

Original languageEnglish
Pages (from-to)741-747
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume83
Issue number7
StatePublished - 1988

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Lynch Syndrome II
Neoplasms
Endometrial Neoplasms
Colonic Neoplasms
Environmental Exposure
Bile Ducts
Duodenum
Brain Neoplasms
Ovary
Breast
Biomarkers
Genotype

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Tumor variation in three extended Lynch syndrome II kindreds. / Lynch, Henry T.; Ens, J.; Lynch, J. F.; Watson, P.

In: American Journal of Gastroenterology, Vol. 83, No. 7, 1988, p. 741-747.

Research output: Contribution to journalArticle

Lynch, HT, Ens, J, Lynch, JF & Watson, P 1988, 'Tumor variation in three extended Lynch syndrome II kindreds', American Journal of Gastroenterology, vol. 83, no. 7, pp. 741-747.
Lynch, Henry T. ; Ens, J. ; Lynch, J. F. ; Watson, P. / Tumor variation in three extended Lynch syndrome II kindreds. In: American Journal of Gastroenterology. 1988 ; Vol. 83, No. 7. pp. 741-747.
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