Abstract
Lynch syndrome II is characterized by an autosomal dominantly inherited susceptibility to early onset colon cancer with proximal predominance, an excess of synchronous and metachronous colonic cancer, carcinoma of the endometrium, ovary, and multiple primary cancer excess. Knowledge of the full tumor spectrum in this disorder(s) remains elusive. Cancers that are uncommon in this disease, but present in three extended Lynch syndrome II families, included brain tumors, carcinoma of the bile duct, duodenum, the urological system, and breasts. Long-term followup of these families (as long as two decades) provided the opportunity to trace in depth this tumor spectrum. Full scrutiny of cancer of all anatomic sites in the absence of biomarkers of high sensitivity and specificity to the cancer-prone genotype will be necessary to comprehend more clearly whether these (or other) cancer sites are integral to this disorder, whether common environmental exposures are involved and, finally, whether chance can explain these cancer associations.
| Original language | English |
|---|---|
| Pages (from-to) | 741-747 |
| Number of pages | 7 |
| Journal | American Journal of Gastroenterology |
| Volume | 83 |
| Issue number | 7 |
| State | Published - 1988 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
Cite this
Tumor variation in three extended Lynch syndrome II kindreds. / Lynch, Henry T.; Ens, J.; Lynch, J. F.; Watson, P.
In: American Journal of Gastroenterology, Vol. 83, No. 7, 1988, p. 741-747.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tumor variation in three extended Lynch syndrome II kindreds
AU - Lynch, Henry T.
AU - Ens, J.
AU - Lynch, J. F.
AU - Watson, P.
PY - 1988
Y1 - 1988
N2 - Lynch syndrome II is characterized by an autosomal dominantly inherited susceptibility to early onset colon cancer with proximal predominance, an excess of synchronous and metachronous colonic cancer, carcinoma of the endometrium, ovary, and multiple primary cancer excess. Knowledge of the full tumor spectrum in this disorder(s) remains elusive. Cancers that are uncommon in this disease, but present in three extended Lynch syndrome II families, included brain tumors, carcinoma of the bile duct, duodenum, the urological system, and breasts. Long-term followup of these families (as long as two decades) provided the opportunity to trace in depth this tumor spectrum. Full scrutiny of cancer of all anatomic sites in the absence of biomarkers of high sensitivity and specificity to the cancer-prone genotype will be necessary to comprehend more clearly whether these (or other) cancer sites are integral to this disorder, whether common environmental exposures are involved and, finally, whether chance can explain these cancer associations.
AB - Lynch syndrome II is characterized by an autosomal dominantly inherited susceptibility to early onset colon cancer with proximal predominance, an excess of synchronous and metachronous colonic cancer, carcinoma of the endometrium, ovary, and multiple primary cancer excess. Knowledge of the full tumor spectrum in this disorder(s) remains elusive. Cancers that are uncommon in this disease, but present in three extended Lynch syndrome II families, included brain tumors, carcinoma of the bile duct, duodenum, the urological system, and breasts. Long-term followup of these families (as long as two decades) provided the opportunity to trace in depth this tumor spectrum. Full scrutiny of cancer of all anatomic sites in the absence of biomarkers of high sensitivity and specificity to the cancer-prone genotype will be necessary to comprehend more clearly whether these (or other) cancer sites are integral to this disorder, whether common environmental exposures are involved and, finally, whether chance can explain these cancer associations.
UR - http://www.scopus.com/inward/record.url?scp=0023682284&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023682284&partnerID=8YFLogxK
M3 - Article
C2 - 3381806
AN - SCOPUS:0023682284
VL - 83
SP - 741
EP - 747
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 7
ER -