Tuning in to the amazing outer hair cell: Membrane wizardry with a twist and shout

D. Z.Z. He, J. Zheng, F. Kalinec, S. Kakehata, J. Santos-Sacchi

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


In an attempt to expand on the pioneering work of the latter part of the last century, a feverish quest continues to uncover the events that lead to cochlear ampli.cation in mammals. The role of the OHC is certainly paramount, and we now have identified many of its membrane constituents that form the basis of the cell's unique contribution. As this review intimates, the motor protein prestin and its interaction with other players within and beneath the plasma membrane drive the cell's augmentation of mammalian hearing acuity. Nevertheless, we are far from understanding the full complement of cellular elaborations that define the cell's mechanical capabilities, Surely, the next quarter century will tell more.

Original languageEnglish (US)
Pages (from-to)119-134
Number of pages16
JournalJournal of Membrane Biology
Issue number2-3
StatePublished - Jan 2006

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Physiology
  • Cell Biology


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