Abstract
Background: Metastatic renal cell carcinoma (RCC) presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy.Patients and Methods: We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patinet subsequently had multiple tumor recurrences.Results: The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis.Conclusion: Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.
| Original language | English |
|---|---|
| Article number | 155 |
| Journal | World Journal of Surgical Oncology |
| Volume | 9 |
| DOIs | |
| State | Published - Nov 28 2011 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Oncology
- Surgery
Cite this
Twelve-year survival after multiple recurrences and repeated metastasectomies for renal cell Carcinoma. / Wang, Jue; Talmon, Geoffrey A.; Feloney, Michael; Morris, Michael C.
In: World Journal of Surgical Oncology, Vol. 9, 155, 28.11.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Twelve-year survival after multiple recurrences and repeated metastasectomies for renal cell Carcinoma
AU - Wang, Jue
AU - Talmon, Geoffrey A.
AU - Feloney, Michael
AU - Morris, Michael C.
PY - 2011/11/28
Y1 - 2011/11/28
N2 - Background: Metastatic renal cell carcinoma (RCC) presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy.Patients and Methods: We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patinet subsequently had multiple tumor recurrences.Results: The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis.Conclusion: Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.
AB - Background: Metastatic renal cell carcinoma (RCC) presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy.Patients and Methods: We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patinet subsequently had multiple tumor recurrences.Results: The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis.Conclusion: Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.
UR - http://www.scopus.com/inward/record.url?scp=82155203007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82155203007&partnerID=8YFLogxK
U2 - 10.1186/1477-7819-9-155
DO - 10.1186/1477-7819-9-155
M3 - Article
C2 - 22123271
AN - SCOPUS:82155203007
VL - 9
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
SN - 1477-7819
M1 - 155
ER -