Abstract
Two Wistar rat lines selectively bred for high (HAB), and low anxiety-related behavior (LAB) on the elevated plus maze were tested for the fear-sensitized acoustic startle response. The study of male rats from the F9 generation revealed a higher anxiety level of HAB rats on the elevated plus maze. However, the LAB rats displayed a higher baseline and fear-sensitized acoustic startle response compared to HAB rats, although the two rat lines did not differ in freezing duration during the interstimulus intervals in the startle experiment (neither before, nor after, footshocks). Counts of neurons immunoreactive for corticotropin-releasing factor and neuropeptide Y in amygdaloid nuclei did not reveal any differences between the two lines, which is in marked contrast to findings in the Roman rat lines (Yilmazer-Hanke, D. M. et al. [2002]). The data indicate that opposite types of anxiety/fear responses are elicited in HAB/LAB rats in the elevated plus maze and fear-sensitized startle tests. Moreover, the animals displayed a differential fear response in the startle experiment, as assessed by measuring the fear-sensitized startle response and freezing.
| Original language | English |
|---|---|
| Pages (from-to) | 309-318 |
| Number of pages | 10 |
| Journal | Behavior Genetics |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2004 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Genetics
- Genetics(clinical)
- Behavioral Neuroscience
- Psychology(all)
Cite this
Two Wistar Rat Lines Selectively Bred for Anxiety-Related Behavior Show Opposite Reactions in Elevated Plus Maze and Fear-Sensitized Acoustic Startle Tests. / Yilmazer-Hanke, D. M.; Wigger, A.; Linke, R.; Landgraf, R.; Schwegler, H.
In: Behavior Genetics, Vol. 34, No. 3, 05.2004, p. 309-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two Wistar Rat Lines Selectively Bred for Anxiety-Related Behavior Show Opposite Reactions in Elevated Plus Maze and Fear-Sensitized Acoustic Startle Tests
AU - Yilmazer-Hanke, D. M.
AU - Wigger, A.
AU - Linke, R.
AU - Landgraf, R.
AU - Schwegler, H.
PY - 2004/5
Y1 - 2004/5
N2 - Two Wistar rat lines selectively bred for high (HAB), and low anxiety-related behavior (LAB) on the elevated plus maze were tested for the fear-sensitized acoustic startle response. The study of male rats from the F9 generation revealed a higher anxiety level of HAB rats on the elevated plus maze. However, the LAB rats displayed a higher baseline and fear-sensitized acoustic startle response compared to HAB rats, although the two rat lines did not differ in freezing duration during the interstimulus intervals in the startle experiment (neither before, nor after, footshocks). Counts of neurons immunoreactive for corticotropin-releasing factor and neuropeptide Y in amygdaloid nuclei did not reveal any differences between the two lines, which is in marked contrast to findings in the Roman rat lines (Yilmazer-Hanke, D. M. et al. [2002]). The data indicate that opposite types of anxiety/fear responses are elicited in HAB/LAB rats in the elevated plus maze and fear-sensitized startle tests. Moreover, the animals displayed a differential fear response in the startle experiment, as assessed by measuring the fear-sensitized startle response and freezing.
AB - Two Wistar rat lines selectively bred for high (HAB), and low anxiety-related behavior (LAB) on the elevated plus maze were tested for the fear-sensitized acoustic startle response. The study of male rats from the F9 generation revealed a higher anxiety level of HAB rats on the elevated plus maze. However, the LAB rats displayed a higher baseline and fear-sensitized acoustic startle response compared to HAB rats, although the two rat lines did not differ in freezing duration during the interstimulus intervals in the startle experiment (neither before, nor after, footshocks). Counts of neurons immunoreactive for corticotropin-releasing factor and neuropeptide Y in amygdaloid nuclei did not reveal any differences between the two lines, which is in marked contrast to findings in the Roman rat lines (Yilmazer-Hanke, D. M. et al. [2002]). The data indicate that opposite types of anxiety/fear responses are elicited in HAB/LAB rats in the elevated plus maze and fear-sensitized startle tests. Moreover, the animals displayed a differential fear response in the startle experiment, as assessed by measuring the fear-sensitized startle response and freezing.
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U2 - 10.1023/B:BEGE.0000017874.40934.64
DO - 10.1023/B:BEGE.0000017874.40934.64
M3 - Article
C2 - 14990869
AN - SCOPUS:1842562330
VL - 34
SP - 309
EP - 318
JO - Behavior Genetics
JF - Behavior Genetics
SN - 0001-8244
IS - 3
ER -