Two Wistar Rat Lines Selectively Bred for Anxiety-Related Behavior Show Opposite Reactions in Elevated Plus Maze and Fear-Sensitized Acoustic Startle Tests

D. M. Yilmazer-Hanke, A. Wigger, R. Linke, R. Landgraf, H. Schwegler

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Two Wistar rat lines selectively bred for high (HAB), and low anxiety-related behavior (LAB) on the elevated plus maze were tested for the fear-sensitized acoustic startle response. The study of male rats from the F9 generation revealed a higher anxiety level of HAB rats on the elevated plus maze. However, the LAB rats displayed a higher baseline and fear-sensitized acoustic startle response compared to HAB rats, although the two rat lines did not differ in freezing duration during the interstimulus intervals in the startle experiment (neither before, nor after, footshocks). Counts of neurons immunoreactive for corticotropin-releasing factor and neuropeptide Y in amygdaloid nuclei did not reveal any differences between the two lines, which is in marked contrast to findings in the Roman rat lines (Yilmazer-Hanke, D. M. et al. [2002]). The data indicate that opposite types of anxiety/fear responses are elicited in HAB/LAB rats in the elevated plus maze and fear-sensitized startle tests. Moreover, the animals displayed a differential fear response in the startle experiment, as assessed by measuring the fear-sensitized startle response and freezing.

Original languageEnglish
Pages (from-to)309-318
Number of pages10
JournalBehavior Genetics
Volume34
Issue number3
DOIs
StatePublished - May 2004
Externally publishedYes

Fingerprint

anxiety
fearfulness
Acoustics
Startle Reflex
Fear
Wistar Rats
acoustics
Anxiety
breeds
freezing
rats
testing
Freezing
experiment
animal
corticotropin-releasing hormone
Neuropeptide Y
Corticotropin-Releasing Hormone
neuropeptide Y
test

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Two Wistar Rat Lines Selectively Bred for Anxiety-Related Behavior Show Opposite Reactions in Elevated Plus Maze and Fear-Sensitized Acoustic Startle Tests. / Yilmazer-Hanke, D. M.; Wigger, A.; Linke, R.; Landgraf, R.; Schwegler, H.

In: Behavior Genetics, Vol. 34, No. 3, 05.2004, p. 309-318.

Research output: Contribution to journalArticle

Yilmazer-Hanke, D. M. ; Wigger, A. ; Linke, R. ; Landgraf, R. ; Schwegler, H. / Two Wistar Rat Lines Selectively Bred for Anxiety-Related Behavior Show Opposite Reactions in Elevated Plus Maze and Fear-Sensitized Acoustic Startle Tests. In: Behavior Genetics. 2004 ; Vol. 34, No. 3. pp. 309-318.
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