Abstract
Conclusion: In the current study, hair cells of vestibular terminal organs in rats were completely eliminated with trans-scala vestibuli injection of neomycin, and then the Math1 gene was transferred. It was shown that type I vestibular hair cells were regenerated and synapses were formed. Objectives: The objective of this study was to identify the cell type of the regenerated vestibular hair cells and relative innervation and synaptic linkage after hair cells of vestibular terminal organs in rats were completely eliminated. Methods: Neomycin injection was used to eliminate all the vestibular terminal organs, and then the animals were treated with an injection of Ad-Math1-EGFP in the scala vestibuli of the cochlea. Results: Math1 gene transfer into the inner ear induced type I hair cell regeneration and synaptic formation. However, neither the number nor the appearance of the hair cells was normal.
| Original language | English |
|---|---|
| Pages (from-to) | 819-828 |
| Number of pages | 10 |
| Journal | Acta Oto-Laryngologica |
| Volume | 132 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2012 |
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All Science Journal Classification (ASJC) codes
- Otorhinolaryngology
Cite this
Type i hair cell regeneration induced by Math1 gene transfer following neomycin ototoxicity in rat vestibular sensory epithelium. / Xu, Jin Cao; Huang, De Liang; Hou, Zhao Hui; Guo, Wei Wei; Sun, Jian He; Zhao, Li Dong; Yu, Ning; Young, Wie Yen; He, David Z.; Yang, Shi Ming.
In: Acta Oto-Laryngologica, Vol. 132, No. 8, 08.2012, p. 819-828.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Type i hair cell regeneration induced by Math1 gene transfer following neomycin ototoxicity in rat vestibular sensory epithelium
AU - Xu, Jin Cao
AU - Huang, De Liang
AU - Hou, Zhao Hui
AU - Guo, Wei Wei
AU - Sun, Jian He
AU - Zhao, Li Dong
AU - Yu, Ning
AU - Young, Wie Yen
AU - He, David Z.
AU - Yang, Shi Ming
PY - 2012/8
Y1 - 2012/8
N2 - Conclusion: In the current study, hair cells of vestibular terminal organs in rats were completely eliminated with trans-scala vestibuli injection of neomycin, and then the Math1 gene was transferred. It was shown that type I vestibular hair cells were regenerated and synapses were formed. Objectives: The objective of this study was to identify the cell type of the regenerated vestibular hair cells and relative innervation and synaptic linkage after hair cells of vestibular terminal organs in rats were completely eliminated. Methods: Neomycin injection was used to eliminate all the vestibular terminal organs, and then the animals were treated with an injection of Ad-Math1-EGFP in the scala vestibuli of the cochlea. Results: Math1 gene transfer into the inner ear induced type I hair cell regeneration and synaptic formation. However, neither the number nor the appearance of the hair cells was normal.
AB - Conclusion: In the current study, hair cells of vestibular terminal organs in rats were completely eliminated with trans-scala vestibuli injection of neomycin, and then the Math1 gene was transferred. It was shown that type I vestibular hair cells were regenerated and synapses were formed. Objectives: The objective of this study was to identify the cell type of the regenerated vestibular hair cells and relative innervation and synaptic linkage after hair cells of vestibular terminal organs in rats were completely eliminated. Methods: Neomycin injection was used to eliminate all the vestibular terminal organs, and then the animals were treated with an injection of Ad-Math1-EGFP in the scala vestibuli of the cochlea. Results: Math1 gene transfer into the inner ear induced type I hair cell regeneration and synaptic formation. However, neither the number nor the appearance of the hair cells was normal.
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UR - http://www.scopus.com/inward/citedby.url?scp=84864201555&partnerID=8YFLogxK
U2 - 10.3109/00016489.2012.673233
DO - 10.3109/00016489.2012.673233
M3 - Article
VL - 132
SP - 819
EP - 828
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 8
ER -