TY - JOUR
T1 - Ultrasound velocity through bone predicts incident vertebral deformity
AU - Heaney, R. P.
AU - Avioli, L. V.
AU - Chesnut, C. H.
AU - Lappe, J.
AU - Recker, R. R.
AU - Brandenburger, G. H.
PY - 1995/3
Y1 - 1995/3
N2 - We followed 130 postmenopausal women without evidence of vertebral deformity by lateral spine radiographs on entry into study for 2 years, and repeat spine radiographs were taken at the end of that time. Incident deformities occurring within this 2 year period were detected by two methods, a level-specific radiogrammetric approach and visual inspection by skilled clinicians. Fourteen incident deformities were detected by the radiogrammetric method, and 19 by the clinicians. Ultrasound transmission velocity was measured at the patella in each subject on entry. Values for ultrasound velocity were significantly correlated with incident fracture occurrence, with individuals having velocity values more than one standard deviation below the mean for the group exhibiting from 3.3 to 4.6 times the probability of incident fracture as individuals with velocity values more than one standard deviation above the mean. Thus, low values for ultrasound transmission velocity at the patella detect yet-unexpressed bony fragility at the spine and predict future fracture.
AB - We followed 130 postmenopausal women without evidence of vertebral deformity by lateral spine radiographs on entry into study for 2 years, and repeat spine radiographs were taken at the end of that time. Incident deformities occurring within this 2 year period were detected by two methods, a level-specific radiogrammetric approach and visual inspection by skilled clinicians. Fourteen incident deformities were detected by the radiogrammetric method, and 19 by the clinicians. Ultrasound transmission velocity was measured at the patella in each subject on entry. Values for ultrasound velocity were significantly correlated with incident fracture occurrence, with individuals having velocity values more than one standard deviation below the mean for the group exhibiting from 3.3 to 4.6 times the probability of incident fracture as individuals with velocity values more than one standard deviation above the mean. Thus, low values for ultrasound transmission velocity at the patella detect yet-unexpressed bony fragility at the spine and predict future fracture.
UR - http://www.scopus.com/inward/record.url?scp=0028921615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028921615&partnerID=8YFLogxK
U2 - 10.1002/jbmr.5650100302
DO - 10.1002/jbmr.5650100302
M3 - Article
C2 - 7785453
AN - SCOPUS:0028921615
VL - 10
SP - 341
EP - 345
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 3
ER -