Abstract
Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.
| Original language | English |
|---|---|
| Pages (from-to) | 588-593 |
| Number of pages | 6 |
| Journal | Journal of the American Academy of Dermatology |
| Volume | 57 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2007 |
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All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels : The effect of UVB dose and skin color. / Armas, Laura A G; Dowell, Susan; Akhter, Mohammed P.; Duthuluru, Sowjanya; Huerter, Christopher; Hollis, Bruce W.; Lund, Richard; Heaney, Robert P.
In: Journal of the American Academy of Dermatology, Vol. 57, No. 4, 10.2007, p. 588-593.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels
T2 - The effect of UVB dose and skin color
AU - Armas, Laura A G
AU - Dowell, Susan
AU - Akhter, Mohammed P.
AU - Duthuluru, Sowjanya
AU - Huerter, Christopher
AU - Hollis, Bruce W.
AU - Lund, Richard
AU - Heaney, Robert P.
PY - 2007/10
Y1 - 2007/10
N2 - Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.
AB - Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.
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U2 - 10.1016/j.jaad.2007.03.004
DO - 10.1016/j.jaad.2007.03.004
M3 - Article
VL - 57
SP - 588
EP - 593
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 4
ER -