Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels

The effect of UVB dose and skin color

Laura A G Armas, Susan Dowell, Mohammed P. Akhter, Sowjanya Duthuluru, Christopher Huerter, Bruce W. Hollis, Richard Lund, Robert P. Heaney

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.

Original languageEnglish
Pages (from-to)588-593
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume57
Issue number4
DOIs
StatePublished - Oct 2007

Fingerprint

Skin Pigmentation
Radiation
Tanning
Serum
Vitamin D
Light
Ultraviolet Rays
25-hydroxyvitamin D
Skin
hydroxide ion

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels : The effect of UVB dose and skin color. / Armas, Laura A G; Dowell, Susan; Akhter, Mohammed P.; Duthuluru, Sowjanya; Huerter, Christopher; Hollis, Bruce W.; Lund, Richard; Heaney, Robert P.

In: Journal of the American Academy of Dermatology, Vol. 57, No. 4, 10.2007, p. 588-593.

Research output: Contribution to journalArticle

Armas, Laura A G ; Dowell, Susan ; Akhter, Mohammed P. ; Duthuluru, Sowjanya ; Huerter, Christopher ; Hollis, Bruce W. ; Lund, Richard ; Heaney, Robert P. / Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels : The effect of UVB dose and skin color. In: Journal of the American Academy of Dermatology. 2007 ; Vol. 57, No. 4. pp. 588-593.
@article{506b09d498034952b97408a86edf4ebf,
title = "Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color",
abstract = "Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90{\%} of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.",
author = "Armas, {Laura A G} and Susan Dowell and Akhter, {Mohammed P.} and Sowjanya Duthuluru and Christopher Huerter and Hollis, {Bruce W.} and Richard Lund and Heaney, {Robert P.}",
year = "2007",
month = "10",
doi = "10.1016/j.jaad.2007.03.004",
language = "English",
volume = "57",
pages = "588--593",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels

T2 - The effect of UVB dose and skin color

AU - Armas, Laura A G

AU - Dowell, Susan

AU - Akhter, Mohammed P.

AU - Duthuluru, Sowjanya

AU - Huerter, Christopher

AU - Hollis, Bruce W.

AU - Lund, Richard

AU - Heaney, Robert P.

PY - 2007/10

Y1 - 2007/10

N2 - Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.

AB - Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.

UR - http://www.scopus.com/inward/record.url?scp=34548522800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548522800&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2007.03.004

DO - 10.1016/j.jaad.2007.03.004

M3 - Article

VL - 57

SP - 588

EP - 593

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 4

ER -