Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color

Laura A.G. Armas; Susan Dowell; Mohammed Akhter; Sowjanya Duthuluru; Christopher Huerter; Bruce W. Hollis; Richard Lund; Robert P. Heaney

doi:10.1016/j.jaad.2007.03.004

Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color

Laura A.G. Armas, Susan Dowell, Mohammed Akhter, Sowjanya Duthuluru, Christopher Huerter, Bruce W. Hollis, Richard Lund, Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Article › peer-review

213 Scopus citations

Abstract

Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm ²) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.

Original language	English (US)
Pages (from-to)	588-593
Number of pages	6
Journal	Journal of the American Academy of Dermatology
Volume	57
Issue number	4
DOIs	https://doi.org/10.1016/j.jaad.2007.03.004
State	Published - Oct 2007

All Science Journal Classification (ASJC) codes

Dermatology

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Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels : The effect of UVB dose and skin color. / Armas, Laura A.G.; Dowell, Susan; Akhter, Mohammed; Duthuluru, Sowjanya; Huerter, Christopher; Hollis, Bruce W.; Lund, Richard; Heaney, Robert P.

In: Journal of the American Academy of Dermatology, Vol. 57, No. 4, 10.2007, p. 588-593.

Research output: Contribution to journal › Article › peer-review

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title = "Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color",

abstract = "Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.",

author = "Armas, {Laura A.G.} and Susan Dowell and Mohammed Akhter and Sowjanya Duthuluru and Christopher Huerter and Hollis, {Bruce W.} and Richard Lund and Heaney, {Robert P.}",

note = "Funding Information: Supported by Dialysis Clinics Inc, The Endocrine Fellows Foundation, and research funds of Creighton University. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

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AU - Duthuluru, Sowjanya

AU - Huerter, Christopher

AU - Hollis, Bruce W.

AU - Lund, Richard

AU - Heaney, Robert P.

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N2 - Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.

AB - Background: Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized. Objective: We sought to define the relationship between UVB exposure and 25-hydroxyvitamin D (25-OH-D) concentrations as a function of skin pigmentation. Methods: Seventy two participants with various skin tones had 90% of their skin exposed to UVB light (20-80 mJ/cm 2) 3 times a week for 4 weeks. Serum 25-OH-D was measured weekly. Results: Eighty percent of the variation in treatment response was explained by UVB dose and skin tone. Therapeutically important changes in 25-OH-D were achieved with minimal tanning. Limitations: Four weeks was not long enough to reach a steady state at the higher dose rates. Conclusions: The response of 25-OH-D levels to UVB light is dependent on skin pigmentation and the amount of UVB given, and useful increases in vitamin D status can be achieved by defined UVB doses small enough to produce only minimal tanning.

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Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color

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