Unaltered membrane properties of arterial muscle in Dahl strain genetic hypertension.

Peter W. Abel, A. Trapani, N. Matsuki, M. J. Ingram, F. D. Ingram, K. Hermsmeyer

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To characterize membrane properties of arterial muscle from Dahl strain hypertensive rats, we measured caudal artery contractile sensitivity to norepinephrine and serotonin, membrane potential at 16 and 37 degrees C, and intracellular potassium, sodium, and chloride content. Dahl salt-resistant (R) strain fed low- or high-salt diets and Dahl salt-sensitive (S) strain fed a low-salt diet remained normotensive. The Dahl S strain on high-salt diets became hypertensive after 4 wk of high salt feeding. There was no significant difference in the norepinephrine or serotonin effective concentration (EC) EC50, EC10, or maximum response between the hypertensive and any of the three normotensive groups. Membrane potential measured at 37 and 16 degrees C and electron-probe analysis of intracellular potassium, sodium, and chloride concentration showed no significant differences between the four groups of animals. These results that arterial muscle membrane mechanisms are not altered in genetically hypertensive Dahl salt-sensitive rats.

Original languageEnglish
JournalThe American journal of physiology
Volume241
Issue number2
StatePublished - Aug 1981
Externally publishedYes

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Salts
Hypertension
Muscles
Membranes
Inbred Dahl Rats
Potassium Chloride
Sodium Chloride
Membrane Potentials
Serotonin
Norepinephrine
Diet
Sodium-Restricted Diet
Arteries
Electrons

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Abel, P. W., Trapani, A., Matsuki, N., Ingram, M. J., Ingram, F. D., & Hermsmeyer, K. (1981). Unaltered membrane properties of arterial muscle in Dahl strain genetic hypertension. The American journal of physiology, 241(2).

Unaltered membrane properties of arterial muscle in Dahl strain genetic hypertension. / Abel, Peter W.; Trapani, A.; Matsuki, N.; Ingram, M. J.; Ingram, F. D.; Hermsmeyer, K.

In: The American journal of physiology, Vol. 241, No. 2, 08.1981.

Research output: Contribution to journalArticle

Abel, PW, Trapani, A, Matsuki, N, Ingram, MJ, Ingram, FD & Hermsmeyer, K 1981, 'Unaltered membrane properties of arterial muscle in Dahl strain genetic hypertension.', The American journal of physiology, vol. 241, no. 2.
Abel, Peter W. ; Trapani, A. ; Matsuki, N. ; Ingram, M. J. ; Ingram, F. D. ; Hermsmeyer, K. / Unaltered membrane properties of arterial muscle in Dahl strain genetic hypertension. In: The American journal of physiology. 1981 ; Vol. 241, No. 2.
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