Upregulation of MUC4 in cervical squamous cell carcinoma: Pathologic significance

Elizabeth G. Munro, Maneesh Jain, Esther Oliva, Neel Kamal, Subodh M. Lele, Maureen P. Lynch, Lankai Guo, Kai Fu, Poonam Sharma, Steve Remmenga, Whitfield B. Growdon, John S. Davis, Bo R. Rueda, Surinder K. Batra

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

MUC4 is a transmembrane glycoprotein more highly expressed in cervical dysplasia than benign cervical epithelium. We sought to determine whether MUC4 expression differs between benign and malignant cervical tissue. Fifty-eight patients with benign, dysplastic, or malignant cervical pathology were identified retrospectively, and representative sections were stained with a mouse monoclonal anti-MUC4 antibody. Semiquantitative analysis was performed on benign, dysplastic, and malignant regions by scoring staining intensity (0: negative, 1: weak, 2: moderate, and 3: strong) and distribution (focal

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalInternational Journal of Gynecological Pathology
Volume28
Issue number2
DOIs
StatePublished - Mar 1 2009

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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    Munro, E. G., Jain, M., Oliva, E., Kamal, N., Lele, S. M., Lynch, M. P., Guo, L., Fu, K., Sharma, P., Remmenga, S., Growdon, W. B., Davis, J. S., Rueda, B. R., & Batra, S. K. (2009). Upregulation of MUC4 in cervical squamous cell carcinoma: Pathologic significance. International Journal of Gynecological Pathology, 28(2), 127-133. https://doi.org/10.1097/PGP.0b013e318184f3e0