Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala

Olga Torres, Jorge Matute, Janee Gelineau-van Waes, Joyce R. Maddox, Simon G. Gregory, Allison E. Ashley-Koch, Jency L. Showker, Nicholas C. Zitomer, Kenneth A. Voss, Ronald T. Riley

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Abstract

Scope: Fumonisin (FB) intake can be high when maize is a dietary staple. We determined (i) urinary FB (UFB) in women consuming maize in high- and low-exposure communities in Guatemala, (ii) the FB levels in maize, (iii) the relationship between UFB and FB intake, and (iv) the relative excretion of UFB1, UFB2, and UFB3. Methods and results: Urine and maize were analyzed for FB for 1 year in three departments. Maize consumption was estimated by an interview questionnaire. Fumonisin B1, B2, and B3 (FB1, FB2 and FB3), were detected in 100% of maize samples. FB1 in maize and urine was significantly higher in Jutiapa compared to Chimaltenango or Escuintla. The FB intake paralleled UFB1 in a dose-dependent manner but UFB1 was present in much higher levels than UFB2 or UFB3 compared to maize. Conclusion: In Jutiapa, agroecological conditions favored FB production. UFB1 mirrored the estimated FB intake. UFB1 > 0.1 ng/mL resulted in a dose-dependent increase in the risk of exceeding FB intake of 2 μg/kg b.w./day compared to women with no detectable UFB1. More than 50% exceeded 2 μg/kg b.w./day when UFB1 was >0.5 ng/mL. UFB2 and UFB3 were rarely detected confirming that FB1 is either absorbed better or preferentially excreted in urine.

Original languageEnglish
Pages (from-to)973-983
Number of pages11
JournalMolecular Nutrition and Food Research
Volume58
Issue number5
DOIs
StatePublished - 2014

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Guatemala
Fumonisins
fumonisin B1
fumonisins
Zea mays
corn
urine
Urine
staples
dosage
interviews
questionnaires
excretion
Interviews

All Science Journal Classification (ASJC) codes

  • Food Science
  • Biotechnology
  • Medicine(all)

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Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala. / Torres, Olga; Matute, Jorge; Gelineau-van Waes, Janee; Maddox, Joyce R.; Gregory, Simon G.; Ashley-Koch, Allison E.; Showker, Jency L.; Zitomer, Nicholas C.; Voss, Kenneth A.; Riley, Ronald T.

In: Molecular Nutrition and Food Research, Vol. 58, No. 5, 2014, p. 973-983.

Research output: Contribution to journalArticle

Torres, O, Matute, J, Gelineau-van Waes, J, Maddox, JR, Gregory, SG, Ashley-Koch, AE, Showker, JL, Zitomer, NC, Voss, KA & Riley, RT 2014, 'Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala', Molecular Nutrition and Food Research, vol. 58, no. 5, pp. 973-983. https://doi.org/10.1002/mnfr.201300481
Torres, Olga ; Matute, Jorge ; Gelineau-van Waes, Janee ; Maddox, Joyce R. ; Gregory, Simon G. ; Ashley-Koch, Allison E. ; Showker, Jency L. ; Zitomer, Nicholas C. ; Voss, Kenneth A. ; Riley, Ronald T. / Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala. In: Molecular Nutrition and Food Research. 2014 ; Vol. 58, No. 5. pp. 973-983.
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abstract = "Scope: Fumonisin (FB) intake can be high when maize is a dietary staple. We determined (i) urinary FB (UFB) in women consuming maize in high- and low-exposure communities in Guatemala, (ii) the FB levels in maize, (iii) the relationship between UFB and FB intake, and (iv) the relative excretion of UFB1, UFB2, and UFB3. Methods and results: Urine and maize were analyzed for FB for 1 year in three departments. Maize consumption was estimated by an interview questionnaire. Fumonisin B1, B2, and B3 (FB1, FB2 and FB3), were detected in 100{\%} of maize samples. FB1 in maize and urine was significantly higher in Jutiapa compared to Chimaltenango or Escuintla. The FB intake paralleled UFB1 in a dose-dependent manner but UFB1 was present in much higher levels than UFB2 or UFB3 compared to maize. Conclusion: In Jutiapa, agroecological conditions favored FB production. UFB1 mirrored the estimated FB intake. UFB1 > 0.1 ng/mL resulted in a dose-dependent increase in the risk of exceeding FB intake of 2 μg/kg b.w./day compared to women with no detectable UFB1. More than 50{\%} exceeded 2 μg/kg b.w./day when UFB1 was >0.5 ng/mL. UFB2 and UFB3 were rarely detected confirming that FB1 is either absorbed better or preferentially excreted in urine.",
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AU - Torres, Olga

AU - Matute, Jorge

AU - Gelineau-van Waes, Janee

AU - Maddox, Joyce R.

AU - Gregory, Simon G.

AU - Ashley-Koch, Allison E.

AU - Showker, Jency L.

AU - Zitomer, Nicholas C.

AU - Voss, Kenneth A.

AU - Riley, Ronald T.

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N2 - Scope: Fumonisin (FB) intake can be high when maize is a dietary staple. We determined (i) urinary FB (UFB) in women consuming maize in high- and low-exposure communities in Guatemala, (ii) the FB levels in maize, (iii) the relationship between UFB and FB intake, and (iv) the relative excretion of UFB1, UFB2, and UFB3. Methods and results: Urine and maize were analyzed for FB for 1 year in three departments. Maize consumption was estimated by an interview questionnaire. Fumonisin B1, B2, and B3 (FB1, FB2 and FB3), were detected in 100% of maize samples. FB1 in maize and urine was significantly higher in Jutiapa compared to Chimaltenango or Escuintla. The FB intake paralleled UFB1 in a dose-dependent manner but UFB1 was present in much higher levels than UFB2 or UFB3 compared to maize. Conclusion: In Jutiapa, agroecological conditions favored FB production. UFB1 mirrored the estimated FB intake. UFB1 > 0.1 ng/mL resulted in a dose-dependent increase in the risk of exceeding FB intake of 2 μg/kg b.w./day compared to women with no detectable UFB1. More than 50% exceeded 2 μg/kg b.w./day when UFB1 was >0.5 ng/mL. UFB2 and UFB3 were rarely detected confirming that FB1 is either absorbed better or preferentially excreted in urine.

AB - Scope: Fumonisin (FB) intake can be high when maize is a dietary staple. We determined (i) urinary FB (UFB) in women consuming maize in high- and low-exposure communities in Guatemala, (ii) the FB levels in maize, (iii) the relationship between UFB and FB intake, and (iv) the relative excretion of UFB1, UFB2, and UFB3. Methods and results: Urine and maize were analyzed for FB for 1 year in three departments. Maize consumption was estimated by an interview questionnaire. Fumonisin B1, B2, and B3 (FB1, FB2 and FB3), were detected in 100% of maize samples. FB1 in maize and urine was significantly higher in Jutiapa compared to Chimaltenango or Escuintla. The FB intake paralleled UFB1 in a dose-dependent manner but UFB1 was present in much higher levels than UFB2 or UFB3 compared to maize. Conclusion: In Jutiapa, agroecological conditions favored FB production. UFB1 mirrored the estimated FB intake. UFB1 > 0.1 ng/mL resulted in a dose-dependent increase in the risk of exceeding FB intake of 2 μg/kg b.w./day compared to women with no detectable UFB1. More than 50% exceeded 2 μg/kg b.w./day when UFB1 was >0.5 ng/mL. UFB2 and UFB3 were rarely detected confirming that FB1 is either absorbed better or preferentially excreted in urine.

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