Use of FTIR spectroscopic imaging to identify parameters associated with fragility fracture

Samuel Gourion-Arsiquaud, Dan Faibish, Elizabeth Myers, Lyudmila Spevak, Juliet Compston, Anthony Hodsman, Elizabeth Shane, Robert R. Recker, Elizabeth R. Boskey, Adele L. Boskey

Research output: Contribution to journalArticlepeer-review

148 Scopus citations


BMD does not entirely explain an individual's risk of fracture. The purpose of this study was to assess whether specific differences in spatially resolved bone composition also contribute to fracture risk. These differences were assessed using Fourier transform infrared spectroscopic imaging (FTIRI) and analyzed through multiple logistic regression. Models were constructed to determine whether FTIRI measured parameters describing mineral content, mineral crystal size and perfection, and collagen maturity were associated with fracture. Cortical and cancellous bone were independently evaluated in iliac crest biopsies from 54 women (32 with fractures, 22 without) who had significantly different spine but not hip BMDs and ranged in age from 30 to 83 yr. The parameters that were significantly associated with fracture in the model were cortical and cancellous collagen maturity (increased with increased fracture risk), cortical mineral/ matrix ratio (higher with increased fracture risk), and cancellous crystallinity (increased with increased fracture risk). As expected, because of its correlation with cortical but not cancellous bone density, hip BMD was significantly associated with fracture risk in the cortical but not the cancellous model. This research suggests that additional parameters associated with fracture risk should be targeted for therapies for osteoporosis.

Original languageEnglish (US)
Pages (from-to)1565-1571
Number of pages7
JournalJournal of Bone and Mineral Research
Issue number9
StatePublished - 2009

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


Dive into the research topics of 'Use of FTIR spectroscopic imaging to identify parameters associated with fragility fracture'. Together they form a unique fingerprint.

Cite this