Use of interferon-α in patients with West Nile encephalitis: Report of 2 cases

Andre C. Kalil, Marcel P. Devetten, Sanjay Singh, Brandi Lesiak, David P. Poage, Kim Bargenquast, Pierre Fayad, Alison G. Freifeld

Research output: Contribution to journalArticle

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Abstract

We describe 2 patients with West Nile virus (WNV) encephalitis who were treated experimentally with interferon (IFN)-α. Both patients demonstrated substantial improvement in mentation and speech on the second day of experimental therapy, and neither required endotracheal intubation or admission to the intensive care unit during hospitalization. Moreover, during the 9-month follow-up period, one patient achieved complete recovery, and the other nearly achieved complete resolution of sequelae. To our knowledge, this is the first published report of the use of IFN-α to treat WNV encephalitis. Clinical trials are underway to further define the role of this therapy in persons with WNV encephalitis.

Original languageEnglish
Pages (from-to)764-766
Number of pages3
JournalClinical Infectious Diseases
Volume40
Issue number5
DOIs
StatePublished - Mar 1 2005

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West Nile virus
Encephalitis
Interferons
Investigational Therapies
Intratracheal Intubation
Intensive Care Units
Hospitalization
Clinical Trials
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Kalil, A. C., Devetten, M. P., Singh, S., Lesiak, B., Poage, D. P., Bargenquast, K., ... Freifeld, A. G. (2005). Use of interferon-α in patients with West Nile encephalitis: Report of 2 cases. Clinical Infectious Diseases, 40(5), 764-766. https://doi.org/10.1086/427945

Use of interferon-α in patients with West Nile encephalitis : Report of 2 cases. / Kalil, Andre C.; Devetten, Marcel P.; Singh, Sanjay; Lesiak, Brandi; Poage, David P.; Bargenquast, Kim; Fayad, Pierre; Freifeld, Alison G.

In: Clinical Infectious Diseases, Vol. 40, No. 5, 01.03.2005, p. 764-766.

Research output: Contribution to journalArticle

Kalil, AC, Devetten, MP, Singh, S, Lesiak, B, Poage, DP, Bargenquast, K, Fayad, P & Freifeld, AG 2005, 'Use of interferon-α in patients with West Nile encephalitis: Report of 2 cases', Clinical Infectious Diseases, vol. 40, no. 5, pp. 764-766. https://doi.org/10.1086/427945
Kalil, Andre C. ; Devetten, Marcel P. ; Singh, Sanjay ; Lesiak, Brandi ; Poage, David P. ; Bargenquast, Kim ; Fayad, Pierre ; Freifeld, Alison G. / Use of interferon-α in patients with West Nile encephalitis : Report of 2 cases. In: Clinical Infectious Diseases. 2005 ; Vol. 40, No. 5. pp. 764-766.
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