Use of neural modeling programs in simulating tissue mechanics and active force generation

Richard J. Hallworth; Ryan Nowakowski; Todd Gureckis

Use of neural modeling programs in simulating tissue mechanics and active force generation

Richard J. Hallworth, Ryan Nowakowski, Todd Gureckis

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The cochlea outer hair cell (OHC) is a sensory receptor cell that exerts a force when electrically stimulated. In order to analyze the mechanical properties of OHC and its force generation, a mathematical model was used based on a neural modeling program Genesis. The model was implemented as a thin-shell fluid-filled closed cylinder whose passive membrane properties were described by two elastic parameters: area modulus and shear modulus. The axial compliance of the model cells increases linearly with length. The force generated against a constant load increases with the cell length. The isometric force is independent of cell length but dependent of the two elastic parameters.

Original language	English
Title of host publication	Southern Biomedical Engineering Conference - Proceedings
Publisher	IEEE
Pages	88
Number of pages	1
State	Published - 1998
Externally published	Yes
Event	Proceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA Duration: Feb 6 1998 → Feb 8 1998

Other

Other	Proceedings of the 1998 17th Southern Biomedical Engineering Conference
City	San Antonio, TX, USA
Period	2/6/98 → 2/8/98

All Science Journal Classification (ASJC) codes

Engineering(all)

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title = "Use of neural modeling programs in simulating tissue mechanics and active force generation",

abstract = "The cochlea outer hair cell (OHC) is a sensory receptor cell that exerts a force when electrically stimulated. In order to analyze the mechanical properties of OHC and its force generation, a mathematical model was used based on a neural modeling program Genesis. The model was implemented as a thin-shell fluid-filled closed cylinder whose passive membrane properties were described by two elastic parameters: area modulus and shear modulus. The axial compliance of the model cells increases linearly with length. The force generated against a constant load increases with the cell length. The isometric force is independent of cell length but dependent of the two elastic parameters.",

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year = "1998",

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booktitle = "Southern Biomedical Engineering Conference - Proceedings",

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T1 - Use of neural modeling programs in simulating tissue mechanics and active force generation

AU - Hallworth, Richard J.

AU - Nowakowski, Ryan

AU - Gureckis, Todd

PY - 1998

Y1 - 1998

N2 - The cochlea outer hair cell (OHC) is a sensory receptor cell that exerts a force when electrically stimulated. In order to analyze the mechanical properties of OHC and its force generation, a mathematical model was used based on a neural modeling program Genesis. The model was implemented as a thin-shell fluid-filled closed cylinder whose passive membrane properties were described by two elastic parameters: area modulus and shear modulus. The axial compliance of the model cells increases linearly with length. The force generated against a constant load increases with the cell length. The isometric force is independent of cell length but dependent of the two elastic parameters.

AB - The cochlea outer hair cell (OHC) is a sensory receptor cell that exerts a force when electrically stimulated. In order to analyze the mechanical properties of OHC and its force generation, a mathematical model was used based on a neural modeling program Genesis. The model was implemented as a thin-shell fluid-filled closed cylinder whose passive membrane properties were described by two elastic parameters: area modulus and shear modulus. The axial compliance of the model cells increases linearly with length. The force generated against a constant load increases with the cell length. The isometric force is independent of cell length but dependent of the two elastic parameters.

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M3 - Conference contribution

AN - SCOPUS:0031653946

SP - 88

BT - Southern Biomedical Engineering Conference - Proceedings

PB - IEEE

Y2 - 6 February 1998 through 8 February 1998

ER -