Use of neural modeling programs in simulating tissue mechanics and active force generation

Richard J. Hallworth, Ryan Nowakowski, Todd Gureckis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The cochlea outer hair cell (OHC) is a sensory receptor cell that exerts a force when electrically stimulated. In order to analyze the mechanical properties of OHC and its force generation, a mathematical model was used based on a neural modeling program Genesis. The model was implemented as a thin-shell fluid-filled closed cylinder whose passive membrane properties were described by two elastic parameters: area modulus and shear modulus. The axial compliance of the model cells increases linearly with length. The force generated against a constant load increases with the cell length. The isometric force is independent of cell length but dependent of the two elastic parameters.

Original languageEnglish
Title of host publicationSouthern Biomedical Engineering Conference - Proceedings
PublisherIEEE
Pages88
Number of pages1
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Other

OtherProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

Fingerprint

Mechanics
Tissue
Elastic moduli
Cells
Mathematical models
Membranes
Mechanical properties
Fluids
Compliance

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Hallworth, R. J., Nowakowski, R., & Gureckis, T. (1998). Use of neural modeling programs in simulating tissue mechanics and active force generation. In Southern Biomedical Engineering Conference - Proceedings (pp. 88). IEEE.

Use of neural modeling programs in simulating tissue mechanics and active force generation. / Hallworth, Richard J.; Nowakowski, Ryan; Gureckis, Todd.

Southern Biomedical Engineering Conference - Proceedings. IEEE, 1998. p. 88.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hallworth, RJ, Nowakowski, R & Gureckis, T 1998, Use of neural modeling programs in simulating tissue mechanics and active force generation. in Southern Biomedical Engineering Conference - Proceedings. IEEE, pp. 88, Proceedings of the 1998 17th Southern Biomedical Engineering Conference, San Antonio, TX, USA, 2/6/98.
Hallworth RJ, Nowakowski R, Gureckis T. Use of neural modeling programs in simulating tissue mechanics and active force generation. In Southern Biomedical Engineering Conference - Proceedings. IEEE. 1998. p. 88
Hallworth, Richard J. ; Nowakowski, Ryan ; Gureckis, Todd. / Use of neural modeling programs in simulating tissue mechanics and active force generation. Southern Biomedical Engineering Conference - Proceedings. IEEE, 1998. pp. 88
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